Considerations for Measurements of Aggregate PFAS Exposure in Precision Environmental Health DOI Creative Commons
Katherine E. Manz

ACS Measurement Science Au, Journal Year: 2024, Volume and Issue: 4(6), P. 620 - 628

Published: Oct. 22, 2024

Per- and polyfluoroalkyl substances (PFAS) have become a major focus of research due to their widespread environmental presence adverse health effects associated with human exposure. PFAS include legacy emerging structures are characterized by range functional groups carbon–fluorine chains that vary in length (from fewer than 3 carbons more 7 carbons). Research has linked exposure an array concerns, ranging from developmental reproductive disorders immune system impairments increased risk certain cancers. In this new era personalized health, measuring markers biospecimens is important part public surveillance. typically measured blood tissues using targeted approaches, which quantify individual specific instrumentation. The diversity complexity PFAS, the limitations approaches sheer number structures, absence publicly available analytical standards pose significant challenges for measurement methodologies. This perspective aims describe aggregate measurements potential use precision medicine applications including discussion benefits these measurements. As organizations, healthcare professionals, look guidance regarding safe pragmatic cost-effective manner, dynamic field science poised respond innovative technological solutions need.

Language: Английский

A systematic review for non-targeted analysis of per- and polyfluoroalkyl substances (PFAS) DOI Creative Commons
David Megson, Pennante Bruce-Vanderpuije, Ifeoluwa Idowu

et al.

The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 960, P. 178240 - 178240

Published: Jan. 1, 2025

This review follows the PRISMA guidelines to provide a systematic of 115 peer reviewed articles that used non-targeted analysis (NTA) methods detect per- and polyfluoroalkylated substances (PFAS). literature highlights significant positive impact NTA in understanding PFAS environment. Within geographical bias exists, with most studies (∼60 %) conducted United States China. Future other regions (such as South America Africa) are needed gain more global understanding. More research is required marine environments atmosphere, current focus mainly on freshwater, groundwater, soil, sediments. The majority measuring environment, rather than commercial products (with exception AFFF). Non-lethal blood sampling has been successful for humans wildlife, but additional biomonitoring exposed cohorts understand health risks biotransformation pathways. mostly use liquid chromatography negative ionisation, which biases towards detection specific PFAS. Despite improvements data reporting quality assurance control (QA/QC) procedures, factors such false rates often overlooked, many workflows remain highly subjective. Perfluoroalkyl carboxylic acids (PFCAs) perfluoroalkyl sulfonic (PFSAs) detected classes, identified over 80 % studies, common routine monitoring. However, our >1000 from total 382 different 300 classes found fewer 5 studies. variety present limitations relying solely targeted methods. monitoring programs regulations would benefit considering comprehensive information

Language: Английский

Citations

4
Occurrence and Fate of Per- and Polyfluoroalkyl Substances (PFAS) in Atmosphere: Size-Dependent Gas-Particle Partitioning, Precipitation Scavenging, and Amplification DOI
Xiaotong Li, Yuan Wang, Jiansheng Cui

et al.

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(21), P. 9283 - 9291

Published: May 16, 2024

The concerns about the fate of per- and polyfluoroalkyl substances (PFAS) in atmosphere are continuously growing. In this study, size-fractionated particles, gas, rainwater samples were simultaneously collected Shijiazhuang, China, to investigate multiphase distribution PFAS atmosphere. Perfluoroalkyl carboxylic acids (PFCAs) dominated total concentration atmospheric media. A strong positive relationship (0.79 < R2 0.99) was observed between PFCAs organic matter fraction (fOM) different particle size fractions, while no such for perfluoroalkyl sulfonic (PFSAs) fOM, suggesting fOM may be an important factor influencing size-dependent PFCAs. Temperature played a key role gas-particle partitioning PFAS, it did not significantly affect their particle-size-dependent distribution. associative fluctuation particle-bound during precipitation suggested that scavenging mechanism removal from Furthermore, temporary increases concentrations precipitation. Fugacity ratios gas phase (log fR/fG ranged 2.0 6.6) indicated trend diffuse precipitation, which explain continued increase even at end

Language: Английский

Citations

13
Screening of Estrogen Receptor Activity of Per- and Polyfluoroalkyl Substances Based on Deep Learning and In Vivo Assessment DOI

Xudi Pang,

Miao Lu, Ying Yang

et al.

Environmental Pollution, Journal Year: 2025, Volume and Issue: unknown, P. 125843 - 125843

Published: Feb. 1, 2025

Language: Английский

Citations

1
Risk prioritization and experimental validation of per- and polyfluoroalkyl substances (PFAS) in Chaohu Lake: based on nontarget and target analyses DOI
Wei Chang, Shendong Xu, Ting Liu

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 138179 - 138179

Published: April 1, 2025

Language: Английский

Citations

0
Unveiling Human Exposure to Plasticizers through Drinking Tea: A Nationwide Study DOI

Yitong Pan,

Shujun Dong, Qingqing Zhu

et al.

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: April 15, 2025

Dietary intake represents a significant exposure pathway for phthalates (PAEs) and nonphthalate plasticizers (NPPs). However, the associated risk linked to tea consumption remains unclear. This study analyzed 10 PAEs NPPs in six types of collected from 18 provinces China. Both were detected all samples, with concentrations ranging 309 8150 ng/g 42.2 899 NPPs, respectively. Source apportionment analysis indicates that packaging materials are important sources plasticizer contamination tea. The di-isobutyl phthalate (DiBP), benzyl-butyl (BzBP), trioctyl trimellitate (TOTM) exhibited correlation those found (r: 0.414-0.465, p < 0.01). Five transformation products (TPs) identified brewed samples through suspect screening analysis, raising concerns about their potential health effects. Comparisons suggest cold brewing may result higher than hot after single brew. as times increased, human rose, ultimately exceeded provides national-scale data on Chinese valuable insights into practices.

Language: Английский

Citations

0
Current status and risk assessment of perfluoroalkyl acids in surface water and sediments of the Yellow River in Shandong, China DOI Creative Commons

Xiubao Wang,

Wenjing Chen, Qingwei Guo

et al.

Emerging contaminants, Journal Year: 2024, Volume and Issue: 11(1), P. 100391 - 100391

Published: July 17, 2024

The Yellow River is the main source of water for urban and rural area agricultural irrigation in northern China. Herein, distribution risk assessment perfluoroalkyl acids (PFAAs) were investigated from Shandong Province, total concentration PFAAs (∑PFAAs) surface sediments 37.5–2128 ng/L (mean: 167 ng/L) not detected−6.95 ng/g dry weight (dw) 1.02 dw), respectively. Short-chain PFAAs-perfluorobutanoic acid (PFBA), perfluorohexanoic (PFHxA), perfluorobutane sulfonic (PFBS) most prevalent water. Source analysis showed that firefighting foam (proportion: 31.3 %) textile treatments food packaging 30.3 sources Based on water, ecological potential human health risks assessed. Perfluorooctanoic (PFOA), perfluorononanoate (PFNA), perfluorodecanoate (PFDA) perfluoroundecanoic (PFUnDA) posed nonnegligible some aquatic organisms. Levels (e.g., PFOA, PFNA, PFDA etc.) samples higher than advisory guidelines concentrations worldwide, indicating a risk. Therefore, PFDA, PFUnDA are key focus pollutants standards limits these environments including sediment should be promoted.

Language: Английский

Citations

3
Serum untargeted lipidomic characterization in a general Chinese cohort with residual per-/polyfluoroalkyl substances by liquid chromatography-drift tube ion mobility-mass spectrometry DOI

Ting Zeng,

Xin Chen, Maria van de Lavoir

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 929, P. 172483 - 172483

Published: April 16, 2024

Language: Английский

Citations

1
Profiling organic pollutants in environmental water by dansylation-based non-targeted liquid chromatography-high resolution mass spectrometry analysis DOI
Бин Чэн,

Lirong An,

Feng Li

et al.

Canadian Journal of Chemistry, Journal Year: 2024, Volume and Issue: 102(9), P. 581 - 588

Published: July 11, 2024

Monitoring organic pollutants in rainwater is important to understand relations between air and water safety. Non-targeted liquid chromatography–mass spectrometry (LC–MS) a powerful tool but because of big differences polarity, ionization efficiency, low concentrations, it challenging detect all single analysis. Chemical derivatization widely adapted strategy fractionate complex samples with enhanced sensitivity selectivity. Herein, we propose the usage dansylation as chemical method improve both LC retention MS containing amine, hydroxyl, carboxyl for non-targeted LC–MS We first evaluated labeling coverage matrix. Using dansyl chloride (DnsCl) hydrazine (DnsHz) label 100 amine- hydroxyl-containing compounds compounds, respectively, found DnsCl DnsHz had over 60% 8 categories compounds. Then was applied rainwater, source water, disinfected drinking samples. To facilitate annotation dansylated also established web-based termed DansylFinder. DansylFinder, 3889, 5813, 6077, 4050 tentative annotations were by dansylation-based LC-HRMS Four hundred fifty four persistently detected samples, suggesting significant overlaps In addition, two degradation pathways reported disinfection process potential path infiltrate system.

Language: Английский

Citations

1
Considerations for Measurements of Aggregate PFAS Exposure in Precision Environmental Health DOI Creative Commons
Katherine E. Manz

ACS Measurement Science Au, Journal Year: 2024, Volume and Issue: 4(6), P. 620 - 628

Published: Oct. 22, 2024

Per- and polyfluoroalkyl substances (PFAS) have become a major focus of research due to their widespread environmental presence adverse health effects associated with human exposure. PFAS include legacy emerging structures are characterized by range functional groups carbon–fluorine chains that vary in length (from fewer than 3 carbons more 7 carbons). Research has linked exposure an array concerns, ranging from developmental reproductive disorders immune system impairments increased risk certain cancers. In this new era personalized health, measuring markers biospecimens is important part public surveillance. typically measured blood tissues using targeted approaches, which quantify individual specific instrumentation. The diversity complexity PFAS, the limitations approaches sheer number structures, absence publicly available analytical standards pose significant challenges for measurement methodologies. This perspective aims describe aggregate measurements potential use precision medicine applications including discussion benefits these measurements. As organizations, healthcare professionals, look guidance regarding safe pragmatic cost-effective manner, dynamic field science poised respond innovative technological solutions need.

Language: Английский

Citations

0