Exposure to Organophosphate Esters and Early Menopause: A Population-Based Cross-Sectional Study DOI
Ting Zhang,

Ruxianguli Aimuzi,

Xiaowei Lu

et al.

Published: Jan. 1, 2024

Organophosphate esters (OPEs), increasingly used as new flame retardants and plasticizers in various products, have been found to reproductive toxicity with overt endocrine disruption potential, yet the relationship between OPEs early menopause remains unexplored. In present study, we U.S. National Health Nutrition Examination Survey data (2011-2020), included a total of 2429 women five urinary OPE metabolite levels information characteristics, investigate associations exposure premature ovarian insufficiency (POI) age menopause.Multivariable adjusted linear regression logistic were assess metabolites POI, respectively. Quantile g computation (QGC) models relative contribution individual mixture. After adjusting for covariates, bis(2-chloroethyl) phosphate (BCEP) concentration was inversely associated (β = - 0.21; 95% confidence interval (CI): 0.41, 0.002). Higher BCEP level (> median) earlier at -1.14, CI: 1.83, 0.46), elevated odds having POI (OR 1.91; 1.02, 3.66). These robust further adjustment cardiometabolic diseases related traits (e.g., body mass index). Further QGC analyses confirmed that dominant contributing most mixture (weight 49.5%) 75.1%). No significant other four metabolites. this cross-sectional increased highlighting potential negative impacts chemical its parent compound tris(2-chloroethyl) on impairment.

Language: Английский

Black phosphorus quantum dots induced neurotoxicity, intestinal microbiome and metabolome dysbiosis in zebrafish (Danio rerio) DOI

Xiaonan Cao,

Li-Li Chen,

Ying‐Xin Fan

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 954, P. 176644 - 176644

Published: Oct. 5, 2024

Language: Английский

Citations

5
Environmental Safety Perspectives on Organophosphate Flame Retardants: Current strategies and advancements in their environmental removal and detection DOI
Xuejuan Ma, Penghui Shang, Zongwei Mei

et al.

Journal of environmental chemical engineering, Journal Year: 2025, Volume and Issue: unknown, P. 115340 - 115340

Published: Jan. 1, 2025

Language: Английский

Citations

0
Underlying mechanisms of metabolic dysfunction-associated steatotic liver disease induced by 2-ethylhexyl diphenyl phosphate and its hydroxylated metabolite in zebrafish (Danio rerio) DOI
Rongyan Yang, Hua Bian, Zhou Zhou

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 493, P. 138407 - 138407

Published: April 24, 2025

Language: Английский

Citations

0
Tire Rubber Antioxidant 6PPD and 6PPD-quinone Disrupt the Energy Supply and Lipid Metabolism of Earthworms DOI
Ruiying Shi, Yanyu Bao, Weitao Liu

et al.

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: May 5, 2025

With the increase in traffic due to urbanization, tire wear particles (TWPs) derived compounds persistently accumulate soil environment. This study addresses critical knowledge gaps regarding ecotoxicological effects of TWP-derived contaminants, N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD) and its precursor, 6PPD-quinone (6PPD-Q), on soil-dwelling organisms. The findings demonstrated that 6PPD-Q accumulated at a higher concentration (6.77 ± 0.124 ng/g) earthworms (Eisenia fetida) compared 6PPD (5.41 0.002 ng/g), triggering more severe oxidative stress cellular homeostatic imbalance. Specifically, 100 ng/g significantly elevated reactive oxygen species (ROS) levels by 180.77% suppressed acetylcholinesterase (AchE) Ca2+-ATPase activities 17.14% 44.70%, respectively. Notably, uniquely disrupted nitrogen balance disturbed energy supply strongly inhibiting fatty acid degradation peroxisome proliferator-activated receptor (PPAR) signaling pathways. Additionally, profoundly altered abundance key microbes microbial network stability, affecting intestinal functions such as bile secretion, hormone synthesis, lipid digestion, thus exacerbating metabolic imbalance earthworms. deciphers molecular toxicity mechanisms contaminants earthworms, providing crucial insights for developing risk assessment frameworks mitigation strategies ecosystems.

Language: Английский

Citations

0
Exposure to organophosphate esters and early menopause: A population-based cross-sectional study DOI Creative Commons
Ting Zhang,

Ruxianguli Aimuzi,

Xiaowei Lu

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: 360, P. 124684 - 124684

Published: Aug. 6, 2024

Organophosphate esters (OPEs), increasingly used as new flame retardants and plasticizers in various products, have been found to reproductive toxicity with overt endocrine disruption potential, yet the relationship between OPEs early menopause remains unexplored. In present study, we included 2429 women who participated U.S. National Health Nutrition Examination Survey data (2011-2020) had of five urinary OPE metabolite levels information characteristics, investigate associations exposure premature ovarian insufficiency (POI) age menopause. Multivariable adjusted linear logistic regression were assess metabolites POI, respectively. Quantile g computation (QGC) models relative contribution individual mixture. After adjusting for covariates, bis(2-chloroethyl) phosphate (BCEP) concentration was inversely associated (β = - 0.21; 95% confidence interval (CI): 0.41, 0.002). Higher BCEP level (>median) earlier at -1.14, CI: 1.83, 0.46), elevated odds having POI (OR 1.93; 1.02, 3.66). These robust further adjustment cardiometabolic diseases related traits (e.g., body mass index). Further QGC analyses confirmed that dominant contributing most mixture (weight 49.5%) 75.1%). No significant other four metabolites. this cross-sectional increased highlighting potential negative impacts chemical its parent compound tris(2-chloroethyl) on function. studies are required validate our findings reveal underlying mechanisms.

Language: Английский

Citations

1
Black Phosphorus Quantum Dots Induced Neurotoxicity, Intestinal Microbiome and Metabolome Dysbiosisin Zebrafish(Danio Rerio) DOI

Xiaonan Cao,

Li-Li Chen,

Ying‐Xin Fan

et al.

Published: Jan. 1, 2024

Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI

Language: Английский

Citations

0
Stable Isotope and Multiomics Reveal Uptake, Translocation, and Transformation Mechanisms of Tris(2-chloroethyl) Phosphate in Wheat (Triticum aestivum L.) DOI

Shuaihao Liu,

Guoguang Wang,

Ziao Xing

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 9, 2024

Uptake, translocation, and transformation mechanisms of tris(2-chloroethyl) phosphate (TCEP) in hydroponic wheat (Triticum aestivum L.) were systematically investigated using compound-specific stable isotope multiomics analyses this study. Results showed that TCEP was quickly adsorbed on root epidermis then absorbed roots via water anion channels as well an active process dependent energy. Active channel preferentially translocated TCEP-containing light carbon isotopes dominated the transmembrane transport to enter vascular bundle. Transcriptomic metabolomic indicated gene-encoding ATP-binding cassette (ABC) transporters purple acid phosphatases (PAPs) glutathione S-transferases (GSTs) involved transformation, respectively. Molecular docking simulations bound hydrophilic cavity ABC transporter/PAP hydrophobic GST, hydrogen bonding important driving force. The results study offered insights for future effective mitigation risk edible plants.

Language: Английский

Citations

0
Insights into Hepatotoxicity of Fluorinated Liquid Crystal Monomer 1-Ethoxy-2,3-difluoro-4-(trans-4-propylcyclohexyl) benzene (EDPrB) in Adult Zebrafish at Environmentally Relevant Concentrations: Metabolic Disorder and Stress Response DOI

Wanlun Li,

Shutao Wang, Hao Fan

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 486, P. 136858 - 136858

Published: Dec. 16, 2024

Language: Английский

Citations

0
Besides Traditional Organophosphate Esters: The Ecological Risks of Emerging Organophosphate Esters in the Yangtze River Basin Cannot Be Ignored DOI

Longfei Zhou,

Xiaolei Wang, Zhang Xiao

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: unknown, P. 125585 - 125585

Published: Dec. 1, 2024

Language: Английский

Citations

0
Exposure to Organophosphate Esters and Early Menopause: A Population-Based Cross-Sectional Study DOI
Ting Zhang,

Ruxianguli Aimuzi,

Xiaowei Lu

et al.

Published: Jan. 1, 2024

Organophosphate esters (OPEs), increasingly used as new flame retardants and plasticizers in various products, have been found to reproductive toxicity with overt endocrine disruption potential, yet the relationship between OPEs early menopause remains unexplored. In present study, we U.S. National Health Nutrition Examination Survey data (2011-2020), included a total of 2429 women five urinary OPE metabolite levels information characteristics, investigate associations exposure premature ovarian insufficiency (POI) age menopause.Multivariable adjusted linear regression logistic were assess metabolites POI, respectively. Quantile g computation (QGC) models relative contribution individual mixture. After adjusting for covariates, bis(2-chloroethyl) phosphate (BCEP) concentration was inversely associated (β = - 0.21; 95% confidence interval (CI): 0.41, 0.002). Higher BCEP level (> median) earlier at -1.14, CI: 1.83, 0.46), elevated odds having POI (OR 1.91; 1.02, 3.66). These robust further adjustment cardiometabolic diseases related traits (e.g., body mass index). Further QGC analyses confirmed that dominant contributing most mixture (weight 49.5%) 75.1%). No significant other four metabolites. this cross-sectional increased highlighting potential negative impacts chemical its parent compound tris(2-chloroethyl) on impairment.

Language: Английский

Citations

0