An Enhanced Protocol to Expand Human Exposome and Machine Learning-Based Prediction for Methodology Application
Ana He,
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Yiming Yao,
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Shijie Chen
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et al.
Environmental Science & Technology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 10, 2025
The
human
exposome
remains
limited
due
to
the
challenging
analytical
strategies
used
reveal
low-level
endocrine-disrupting
chemicals
(EDCs)
and
their
metabolites
in
serum
urine.
This
limits
integrity
of
EDC
exposure
assessment
hinders
understanding
cumulative
health
effects.
In
this
study,
we
propose
an
enhanced
protocol
based
on
multi-solid-phase
extraction
(multi-SPE)
expand
with
polar
EDCs
train
a
machine
learning
(ML)
model
for
methodology
prediction
molecular
descriptors.
measurement
70
(25%)
34
(12%)
out
295
well-acknowledged
urine
compared
hydrophilic–lipophilic
balance
sorbent
alone.
nontarget
analysis
from
20
women
childbearing
age
cohort
498,
controlling
occupational
factors
daily
behaviors
high
chemical
potential,
multi-SPE
increased
10
(40%)
16
(53%)
target
identification
17
(77%)
(36%)
(confidence
≥
level
3)
urine,
respectively.
Interestingly,
ML
predicted
that
could
identify
additional
38%
most
bioactive
chemicals.
conclusion,
advances
by
expanding
profiles.
Language: Английский
Prevalence of tetrabromobisphenol A and its related compounds in an anthropogenic impacted soil-groundwater system: Concern for understudied derivatives
Environmental Chemistry and Ecotoxicology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 1, 2025
Language: Английский
Mechanistic Insights into Carbon Black-Activated AKT/TMEM175 Cascade Impairing Macrophage-Epithelial Cross-Talk and Airway Epithelial Proliferation
Yawen Feng,
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Xiaowen Tang,
No information about this author
Hongying Fu
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et al.
Environmental Pollution,
Journal Year:
2025,
Volume and Issue:
unknown, P. 126076 - 126076
Published: March 1, 2025
Language: Английский
Bioaccumulation and Maternal Transfer of Brominated Flame Retardants in Poultry and the Health Risks from Dietary Exposure
Ying Li,
No information about this author
Ling Wang,
No information about this author
Lei Shi
No information about this author
et al.
Environment & Health,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 17, 2025
Language: Английский
First Evidence of Novel Organothiophosphate Esters as Prevalent New Pollutants in Dust from Automotive Repair Shops Discovered by High-Resolution Mass Spectrometry
Xiaoxia Feng,
No information about this author
Wenzhuo Xu,
No information about this author
Xiaomeng Ji
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et al.
Environmental Science & Technology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 24, 2024
The
occurrence
of
organophosphorus
compounds
has
garnered
global
concern
due
to
their
widespread
production
and
potential
environmental
risks.
Limited
structural
information
hindered
a
comprehensive
understanding
composition.
By
characteristic
fragmentation-based
nontarget
analysis,
the
composition
organothiophosphate
esters
(OTPEs),
which
are
antiwear
additives
in
lubricant
oils
that
have
received
little
attention
previously,
were
investigated
dust
from
automotive
repair
shops
surrounding
buildings.
Fourteen
OTPEs
tentatively
identified,
including
four
triarylphosphorothionates,
six
Language: Английский
Base-driven dehydrohalogenation coupled with catalytic hydrodehalogenation as a novel strategy for rapid dehalogenation of halogenated organic compounds containing aliphatic C-X bonds
Shuting Qin,
No information about this author
Chen Wu,
No information about this author
Xuanxuan Ma
No information about this author
et al.
Journal of environmental chemical engineering,
Journal Year:
2024,
Volume and Issue:
12(6), P. 114983 - 114983
Published: Nov. 29, 2024
Language: Английский