Differential effects of foodborne and waterborne micro(nano)plastics exposure on fish liver metabolism and gut microbiota community

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 488, P. 137471 - 137471

Published: Feb. 2, 2025

Micro(nano)plastics (MNPs) primarily enter fish through two routes: directly ingestion via their diets and respiratory filtration gills. However, the specific impacts of these routes on liver metabolism remain largely unknown. Here, we investigated gene expression profiles Nile tilapia Oreochromis niloticus following equivalent doses foodborne waterborne MNPs exposure. While phenotypes O. showed minimal differences between exposure routes, significant variations were observed in response patterns. Using WGCNA, identified key networks KEGG pathways associated with each type. The primary transcription factors regulating changes thrb for fosl2 stimulus induced metabolic disorders circadian rhythm, whereas inflammatory responses to affect host metabolism. By integrating alterations gut microbiota enrichment data, further found that Firmicutes, Fusobacteriota, Proteobacteria, Chloroflexi jointly regulated mapk13 during exposure, most leading genes was predominantly influenced by Firmicutes. Collectively, our study demonstrated a distinct pattern microbiota-gene gut-liver axis

Language: Английский

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Nanoplastics as Gene and Epigenetic Modulators of Endocrine Functions: A Perspective

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2071 - 2071

Published: Feb. 27, 2025

Nanoplastics (NPs) represent a major challenge in environmental contamination resulting from the physical, chemical, and biological degradation of plastics. Their characterization requires advanced expensive methods, which limit routine analyses. The effects NPs depend on their chemical physical properties, influence toxicity interactions with systems. Studies animal models, such as Daphnia magna Danio rerio, show that induce oxidative stress, inflammation, DNA damage, metabolic alterations, often related to charge particle size. affect endocrine functions by acting disruptors, interfering thyroid sex hormones showing potential transgenerational through epigenetic modifications, including hyper- hypomethylation. Behavioral neurofunctional alterations have been observed rerio mouse suggesting link between NP exposure neurotransmitters dopamine serotonin. Despite limited human studies, presence breast milk placenta underscores need for further investigation health effects. Research focusing genetic markers is encouraged elucidate molecular mechanisms risks associated chronic exposure.

Language: Английский

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Global Distribution Characteristics and Ecological Risk Assessment of Microplastics in Aquatic Organisms Based on Meta-Analysis

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 137977 - 137977

Published: March 1, 2025

Language: Английский

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Marine Micro(nano)plastics Toxicology: Knowledge Gaps and Perspectives

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 138086 - 138086

Published: March 1, 2025

Language: Английский

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Single-cell transcriptomic dynamics of scallop heart reveals the heterogeneous response to heat stress

BMC Biology, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 15, 2025

Language: Английский

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Contrasting the distribution kinetics of microplastics and nanoplastics in medaka following exposure and depuration

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 478, P. 135620 - 135620

Published: Aug. 23, 2024

Language: Английский

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Transcriptome profiling of triploid Crassostrea gigas gills indicates the host immune mechanism against bacterial infection

Comparative Biochemistry and Physiology Part D Genomics and Proteomics, Journal Year: 2024, Volume and Issue: 54, P. 101392 - 101392

Published: Dec. 6, 2024

Language: Английский

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