Industrial
activities
are
a
major
source
of
organophosphorus
flame
retardants
(OPFRs)
and
plasticizers
in
aquatic
environments.
This
study
investigated
the
distribution
40
OPFRs
river
impacted
by
industrial
manufacturing
plants
Eastern
China
target
analysis.
Nontarget
analysis
using
high-resolution
mass
spectrometry
was
further
employed
to
identify
novel
compounds
(NOPs).
Thirty-four
were
detected
water
samples,
with
total
concentrations
62.9–1.06
×
103
ng/L
(median:
455
ng/L).
Triphenylphosphine
oxide
diphenyl
phosphoric
acid
ubiquitously
up
620
127
ng/L,
respectively.
Among
26
identified
NOPs,
17
reported
for
first
time
environment,
including
14
organophosphate
esters
(especially
4
heterocycles
3
oligomers),
2
organophosphites,
an
organophosphonate.
Bis(2,4-di-tert-butylphenyl)
hydrogen
phosphate
2,2-dimethylpropoxy(propyl)phosphinic
high
predicted
persistence
or
toxicity
widely
detected,
semiquantified
990
1.0
Structurally
similar
exhibited
consistent
variation
trends,
suggesting
common
emission
source.
Estimated
annual
discharges
sea
20.6–37.0
kg/yr
30.8–161
NOPs.
These
findings
indicate
that
contribute
NOPs
catchment
its
estuary,
posing
ecological
risks
both
terrestrial
marine
Environmental Science & Technology Letters,
Journal Year:
2024,
Volume and Issue:
11(9), P. 920 - 930
Published: Aug. 13, 2024
Tris(2,4-di-tert-butylphenyl)
phosphite
(AO168)
is
a
widely
utilized
organophosphite
antioxidant
in
the
field
of
plastics.
Throughout
production
and
usage
processes,
AO168
can
undergo
oxidation
convert
into
tris(2,4-di-tert-butylphenyl)
phosphate
(AO168═O),
which
has
been
identified
as
one
novel
organophosphate
esters
(OPEs).
AO168═O
now
extensively
present
environment,
with
concentrations
generally
exceeding
those
traditional
OPEs
such
triphenyl
tri(2-chloroisopropyl)
phosphate.
Consequently,
emerged
significant
concern
that
receiving
attention
from
scientific
community.
However,
there
exists
some
controversy
regarding
formation
mechanisms
potential
risks
AO168═O.
This
Review
provides
comprehensive
overview
for
first
time
environmental
occurrence,
pathways,
toxicities,
linked
to
AO168═O,
aiming
assist
researchers
policymakers
obtaining
an
unbiased
description
its
impacts
on
both
environment
human
health.
Given
numerous
unresolved
aspects
surrounding
along
wide
greater
should
be
devoted
this
emerging
contaminant.
Chemical Research in Toxicology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 10, 2025
Tris(2,4-di-tert-butylphenyl)phosphate
(TDTBPP),
a
novel
organophosphate
ester
(OPE),
has
been
extensively
detected
in
various
environmental
and
biological
samples;
however,
its
potential
effects
remain
unexplored.
In
this
study,
we
investigated
biotransformation
characteristics,
alteration
of
lipid
metabolism,
mRNA
expression
primary
mouse
hepatocytes
(PMHs)
following
exposure
to
TDTBPP.
After
36-h
PMHs,
TDTBPP
exhibited
high
stability
with
no
statistically
significant
degradation
trend.
Subsequently,
analyzed
the
disruption
homeostasis
PMHs
0–4.5
μM
Lipidomic
analysis
indicated
that
disrupted
several
classes
were
dysregulated,
particular,
glycerolipids
glycerophospholipids.
Additionally,
three
lipids
proposed
as
biomarkers
exposure,
including
triglycerides
(TGs)
phosphatidylcholines
(PCs).
These
observations
further
supported
by
transcriptional
changes,
observed
genes
associated
uptake,
de
novo
lipogenesis,
β-oxidation
fatty
acids,
glycerolipid
export.
Overall,
these
findings
highlight
detrimental
on
homeostasis,
providing
important
insights
for
health
risk
assessments
abundant
OPE
environment.
