A Life Cycle Risk Assessment of Nanopesticides in Freshwater

Environmental Science and Ecotechnology, Journal Year: 2025, Volume and Issue: unknown, P. 100565 - 100565

Published: May 1, 2025

Language: Английский

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Deconvoluting the impacts of harmful algal blooms in multi-stressed systems

Nature Water, Journal Year: 2024, Volume and Issue: 2(9), P. 813 - 814

Published: Sept. 6, 2024

Language: Английский

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Sensitivity Variations in Developmental Toxicity of Imidacloprid to Zebrafish Embryos at Different Neurodevelopmental Stages

Environmental Toxicology and Chemistry, Journal Year: 2024, Volume and Issue: 43(11), P. 2398 - 2408

Published: Aug. 26, 2024

Neonicotinoids are ubiquitous in global surface waters and pose a significant risk to aquatic organisms. However, information is lacking on the variations sensitivity of organisms at different developmental stages neurotoxic neonicotinoids. We established spectrum toxicity zebrafish embryos four neurodevelopmental (1, 3, 6, 8 h post fertilization [hpf]) dechorionated 6 hpf based external internal exposure imidacloprid as representative neonicotinoid. Embryos gastrula stage (6 hpf) were more sensitive than earlier stages. Dechorionated with chorion, suggesting that chorion offers protection against pollutants. Nine sublethal effects induced by exposure, among which uninflated swim bladder (USB) was most sensitive. Water depth air availability chambers critical factors influencing occurrence USB larvae. Internal residues metabolites accounted for <10% imidacloprid, indicating metabolized limited fashion embryos. In addition, acute main metabolite 5-hydroxy-imidacloprid significantly lower observed exposed mainly parent compound. Our research fresh perspective choosing initial time embryo tests, particularly neurotoxicants. Environ Toxicol Chem 2024;43:2398-2408. © 2024 SETAC.

Language: Английский

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Predicting uptake and elimination kinetics of chemicals in invertebrates: a technical note on residual variance modeling

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 16, 2024

Abstract Toxicokinetic models for predicting contents of nanomaterials and other toxic chemicals are often fitted without evaluation the residual variance structure. The aim present study was to evaluate various structures, assuming either homoscedasticity or heteroscedasticity, when fitting non-linear toxicokinetic one-compartment uptake, bioaccumulation elimination in invertebrate organisms. Data describing exposure several aquatic terrestrial invertebrates specific metal were available from real experiments evaluating functions models. As proof concept, datasets truly homoscedastic heteroscedastic nature simulated. Depending dataset, applying with different residuals assumption largely affected plots error margins parameters predicted content a chemical. Consequently, selecting most accurate modeling, heteroscedastic, improves prediction chemical organisms estimation associated uptake rates. Highlights Residual indicate if an model toxicological data Choice function affects Selecting proper may prevent false positives negatives

Language: Английский

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Predicting uptake and elimination kinetics of chemicals in invertebrates: A technical note on residual variance modeling

Computational Toxicology, Journal Year: 2024, Volume and Issue: unknown, P. 100337 - 100337

Published: Dec. 1, 2024

Language: Английский

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