Industrial
activities
are
a
major
source
of
organophosphorus
flame
retardants
(OPFRs)
and
plasticizers
in
aquatic
environments.
This
study
investigated
the
distribution
40
OPFRs
river
impacted
by
industrial
manufacturing
plants
Eastern
China
target
analysis.
Nontarget
analysis
using
high-resolution
mass
spectrometry
was
further
employed
to
identify
novel
compounds
(NOPs).
Thirty-four
were
detected
water
samples,
with
total
concentrations
62.9–1.06
×
103
ng/L
(median:
455
ng/L).
Triphenylphosphine
oxide
diphenyl
phosphoric
acid
ubiquitously
up
620
127
ng/L,
respectively.
Among
26
identified
NOPs,
17
reported
for
first
time
environment,
including
14
organophosphate
esters
(especially
4
heterocycles
3
oligomers),
2
organophosphites,
an
organophosphonate.
Bis(2,4-di-tert-butylphenyl)
hydrogen
phosphate
2,2-dimethylpropoxy(propyl)phosphinic
high
predicted
persistence
or
toxicity
widely
detected,
semiquantified
990
1.0
Structurally
similar
exhibited
consistent
variation
trends,
suggesting
common
emission
source.
Estimated
annual
discharges
sea
20.6–37.0
kg/yr
30.8–161
NOPs.
These
findings
indicate
that
contribute
NOPs
catchment
its
estuary,
posing
ecological
risks
both
terrestrial
marine
Abnormal
development
and
mortality
in
early
life
stages
pose
significant
threats
to
the
growth
continuation
of
fish
populations.
Tris(2,4-di-tert-butylphenyl)
phosphate
(TDtBPP)
is
a
novel
organophosphate
ester
contaminant
detected
natural
waters.
However,
potential
effects
maternal
exposure
TDtBPP
on
offspring
embryos
remain
unknown.
Here,
30-day-old
zebrafish
were
exposed
at
0,
50,
500,
or
5000
ng/L
for
180
days,
females
spawned
with
unexposed
males.
accumulation
was
embryos,
accompanied
by
an
increased
malformation
rate
mortality.
The
developmental
abnormality
identified
originate
from
gastrula
stage.
Furthermore,
based
transcriptome
analysis,
down-regulation
RHO
family
interacting
cell
polarization
regulator
2
gene
(ripor2)
considered
as
key
toxic
event,
this
confirmed
subsequent
knockdown
experiment.
Moreover,
molecular
docking
studies
forkhead
box
O1
(foxO1)
transcription
factor
inhibitor
(AS1842856)
experiments
demonstrated
that
blockade
foxO1
transcriptional
regulation
responsible
decreased
expression
ripor2.
results
study
occurrence
following
triggered
consequent
Studies
on
source
apportionment
of
indoor
OPEs
rarely
involve
multiple
media
and
characteristic
markers
emissions.
Herein,
we
present
a
novel
framework
for
quantitative
integrative
appointment
by
integrating
OPE
concentrations
in
multimedia
into
equivalent
(EICs)
using
Utility
was
demonstrated
applying
it
to
five
types
microenvironments
where
the
13
were
ubiquitous
(indoor
dust:
993-14000
ng/g;
air:
0.549-14.1
ng/m3).
The
paired
dust
air
samples
adopted
construct
"Measured-Paired-EICs"
data
set
apportionments
via
positive
matrix
factorization
(PMF).
Moreover,
an
alternative
model
method
constructing
EIC
sets
from
single-medium
measurements
established
improve
applicability
framework.
Accordingly,
"Modeled-Paired-EICs",
"Dust-Only",
"Air-Only"
constructed
comparison.
extracted
factors
exhibited
consistent
contributions
"Modeled-Paired-EICs"
solutions
(RSD:
0.14-5.4%),
while
solution
identified
incomplete
"Dust-Only"
showed
errors
40.6-262%.
Specifically,
PMF
analysis
resolved
seven
known
sources
other
unknown
sources.
Furthermore,
heterogeneities
identification
observed
across
various
exposure
scenarios;
probabilistic
carcinogenic
risk
TCEP
(up
7.19
×
10-7)
close
acceptable
level
(1
10-6)
demands
further
attention.
Environment International,
Journal Year:
2025,
Volume and Issue:
unknown, P. 109445 - 109445
Published: April 1, 2025
Organophosphorus
flame
retardants
and
plasticizers
(OPFRs)
are
prevalent
raise
health
concerns
due
to
their
endocrine-disrupting
properties.
Clinically
detectable
thyroid
nodules
less
common
in
children
than
adults
but
pose
a
higher
malignancy
risk.
The
effects
of
OPFRs
on
children's
relation
oxidative
stress
remain
unknown.
This
cross-sectional
study
analyzed
concentrations
seven
three
biomarkers
(OSBs),
namely
8-oxo-7,8-dihydro-2'-deoxyguanosine
(8-OHdG),
malondialdehyde,
o,
o'-dityrosine
(diY)
521
urine
samples
from
coastal
urbanized
region.
Median
creatinine-adjusted
levels
the
ranged
0.02
0.64
μg/g.
Triphenyl
phosphine
oxide
(TPPO)
was
detected
for
first
time
urine.
Diphenyl
phosphate
(DPHP)
isopropyl
phenyl
(ip-PPP)
were
frequently
detected,
with
median
0.46
μg/g
μg/g,
respectively.
Multiple
linear
regression
analyses
mixture
models
demonstrated
that
positively
associated
OSBs.
Furthermore,
logistic
analysis
revealed
urinary
TPPO
tris(1-chloro-2-propyl)
(TCIPP)
nodule
risk
children,
TCIPP
further
sex-dependent
association
particularly
girls,
although
OSBs
did
not
show
significant
mediating
effects.
Overall,
studies
warranted
explore
potential
mechanisms
linking
exposure
stress,
children.
As
a
novel
organophosphate
ester
(NOPE),
tris(2,4-ditert-butylphenyl)
phosphate
(TDtBPP)
has
attracted
significant
attention
due
to
its
unexpectedly
high
detection
in
natural
environments.
However,
the
ecological
toxic
effects
of
environmentally
relevant
concentrations
TDtBPP
organisms
remain
entirely
unknown.
In
this
study,
1
month
old
zebrafish
were
exposed
0,
50,
500,
or
5000
ng/L
for
150
days,
and
reproductive
toxicity
male
fish
was
evaluated.
Results
demonstrated
that
exposure
significantly
inhibited
maturation
spermatozoa
thus
decreased
spermatogenesis.
Furthermore,
abnormal
sperm
morphology
motility
also
observed.
The
decrease
quantity
quality
eventually
resulted
declining
fecundity.
Moreover,
downregulated
expression
hsd3b1
vivo
vitro
subsequently
synthesis
androgens
testes
Leydig
cells.
This
inhibition
androgen
appeared
be
responsible
observed
fish.
Molecular
docking
dual-luciferase
reporter
gene
experiments
elucidated
promotion
vitamin
D
on
transcription
by
receptor
hsd3b1.
Our
findings
provide
first
time
evidence
poses
risk
reproduction
at
levels.
Environmental Science & Technology,
Journal Year:
2024,
Volume and Issue:
58(39), P. 17441 - 17453
Published: Sept. 19, 2024
This
study
provides
a
comprehensive
investigation
into
the
structure-dependent
uptake,
distribution,
biotransformation,
and
potential
toxicity
effects
of
alkyl
organophosphate
esters
(OPEs)
in
hydroponic
lettuce
(
