A comparative study for organophosphate triesters and diesters in mice via oral gavage exposure: Tissue distribution, excreta elimination, metabolites and toxicity DOI Creative Commons
Wenyu Xu, Wei Zhang, Zechen Yu

et al.

Environment International, Journal Year: 2024, Volume and Issue: 193, P. 109114 - 109114

Published: Nov. 1, 2024

Organophosphate triesters (tri-OPEs) and diesters (di-OPEs) may threaten human health through dietary intake, whereas little information is available about their fate in mammals. Herein, mice exposure experiments were carried out gavage with six tri-OPEs di-OPEs, respectively. The residual levels of di-OPEs generally higher than those tri-OPEs. mainly distributed the liver blood while most remained stomach, indicating easier transfer lower metabolism di-OPEs. accumulation tri- large octanol-water partition coefficients long carbon chain observed tissues feces, implying that elimination these OPEs fecal excretion an important pathway. A total 86 OPE metabolites found murine urine 57 which identified for first time. For tri-OPEs, carboxylated had peak intensities fewer interference factors among metabolites, could serve as ideal biomarkers. predicted oral median lethal doses corresponding showed increased toxicity some hydroxylated needing further attention. These results provided new insights evidence on fates biomarkers

Language: Английский

New insights into the mechanism of triphenyl phosphate and its metabolite diphenyl phosphate in diabetic kidney disease DOI Creative Commons
Ting Fang, Qiaoyan Liu,

Xinxin Huangfu

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 291, P. 117877 - 117877

Published: Feb. 1, 2025

Diabetic kidney disease is a significant complication of diabetes mellitus, and exposure to certain chemicals may play role in its development. Triphenyl phosphate (TPHP) commonly used plastics flame retardants. This study aims investigate the potential impact TPHP metabolite diphenyl (DPHP) on diabetic using various methods, including network toxicology, molecular docking, cell experiments like CCK8 assay real-time-PCR. The research examined relationship between urinary DPHP levels function American adults data from National Health Nutrition Examination Survey (NHANES) 2017 March 2020. Additionally, explored targets action for toxicity analysis, conducted protein interaction functional aspects through Gene Ontology Kyoto Encyclopedia Genes Genomes enrichment analysis. Furthermore, identified key proteins involved experimental verification by treating cells with DPHP. Toxicity analysis showed that could cause dose-dependent mouse podocyte clone 5 (MPC5) mesangial (MES13). also detected mRNA expression core molecularly docked results indicated statistically regulation most MPC5, MES13, human kidney-2 cells.

Language: Английский

Citations

0
Health Risks of Low-Dose Dietary Exposure to Triphenyl Phosphate and Diphenyl Phosphate in Mice: Insights from the Gut–Liver Axis DOI

Jing Cao,

Xinwei Wang, Yumeng Lei

et al.

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: April 29, 2025

Aryl phosphate esters have been detected throughout the natural environment and in human blood samples, making it important to determine health risks associated with exposure triphenyl (TPHP) its metabolite diphenyl (DPHP). Here, C57BL/6J male mice were exposed TPHP or DPHP for 12 weeks at estimated daily intake doses of 0.1 7 μg/kg bw/day. affected levels short-chain fatty acids bile gut, enhancing production 29 medium- long-chain liver by 3.72-fold significantly increasing hepatic lipid cholesterol levels. Metabolomic molecular analysis confirmed that elevated persisted after an 8 week recovery period. Gut microbiota-dependent alterations toxic end points observed TPHP-fed mice, as supported results fecal microbiota transplantation. In DPHP-fed serotonergic glutamatergic synapses simultaneously altered intestine, corresponding reduction five brain neurotransmitters (15.4-60.8%). Decreased carbohydrate insulin resistance mice. These suggest affect metabolism via different modes, mediated through gut-liver axis, providing novel insights into mechanisms organophosphate-ester-mediated metabolic disruption.

Language: Английский

Citations

0
Coupled digital visualization and multi-omics uncover neurobehavioral dysfunction in zebrafish induced by resorcinol bis(diphenylphosphate) DOI Creative Commons

Jing Cao,

Yumeng Lei, Wenhao Li

et al.

Environment International, Journal Year: 2024, Volume and Issue: 192, P. 109023 - 109023

Published: Sept. 19, 2024

Language: Английский

Citations

1
A comparative study for organophosphate triesters and diesters in mice via oral gavage exposure: Tissue distribution, excreta elimination, metabolites and toxicity DOI Creative Commons
Wenyu Xu, Wei Zhang, Zechen Yu

et al.

Environment International, Journal Year: 2024, Volume and Issue: 193, P. 109114 - 109114

Published: Nov. 1, 2024

Organophosphate triesters (tri-OPEs) and diesters (di-OPEs) may threaten human health through dietary intake, whereas little information is available about their fate in mammals. Herein, mice exposure experiments were carried out gavage with six tri-OPEs di-OPEs, respectively. The residual levels of di-OPEs generally higher than those tri-OPEs. mainly distributed the liver blood while most remained stomach, indicating easier transfer lower metabolism di-OPEs. accumulation tri- large octanol-water partition coefficients long carbon chain observed tissues feces, implying that elimination these OPEs fecal excretion an important pathway. A total 86 OPE metabolites found murine urine 57 which identified for first time. For tri-OPEs, carboxylated had peak intensities fewer interference factors among metabolites, could serve as ideal biomarkers. predicted oral median lethal doses corresponding showed increased toxicity some hydroxylated needing further attention. These results provided new insights evidence on fates biomarkers

Language: Английский

Citations

1