Gene expression and DNA methylation changes in response to hypoxia in toxicant-adapted Atlantic killifish (Fundulus heteroclitus) DOI Creative Commons
Neelakanteswar Aluru, Yaamini R. Venkataraman, Christopher S. Murray

et al.

Biology Open, Journal Year: 2025, Volume and Issue: 14(1)

Published: Jan. 6, 2025

ABSTRACT Coastal fish populations are threatened by multiple anthropogenic impacts, including the accumulation of industrial contaminants and increasing frequency hypoxia. Some Atlantic killifish (Fundulus heteroclitus), like those in New Bedford Harbor (NBH), Massachusetts, USA, have evolved a resistance to dioxin-like polychlorinated biphenyls (PCBs) that may influence their ability cope with secondary stressors. To address this question, we compared hepatic gene expression DNA methylation patterns response mild or severe hypoxia from NBH Scorton Creek (SC), reference population relatively pristine environment. We hypothesized would show altered responses due trade-offs linked toxicant resistance. Our results revealed substantial differences between populations. SC demonstrated dose-dependent changes hypoxia, while exhibited muted transcriptional Interestingly, showed significant did not exhibit notable epigenetic alterations. These findings suggest toxicant-adapted face molecular environmental stress, potentially impacting survive coastal habitats. Further research is needed elucidate functional implications these modifications role adaptive stress responses.

Language: Английский

Gene expression and DNA methylation changes in response to hypoxia in toxicant-adapted Atlantic killifish (Fundulus heteroclitus) DOI Creative Commons
Neelakanteswar Aluru, Yaamini R. Venkataraman, Christopher S. Murray

et al.

Biology Open, Journal Year: 2025, Volume and Issue: 14(1)

Published: Jan. 6, 2025

ABSTRACT Coastal fish populations are threatened by multiple anthropogenic impacts, including the accumulation of industrial contaminants and increasing frequency hypoxia. Some Atlantic killifish (Fundulus heteroclitus), like those in New Bedford Harbor (NBH), Massachusetts, USA, have evolved a resistance to dioxin-like polychlorinated biphenyls (PCBs) that may influence their ability cope with secondary stressors. To address this question, we compared hepatic gene expression DNA methylation patterns response mild or severe hypoxia from NBH Scorton Creek (SC), reference population relatively pristine environment. We hypothesized would show altered responses due trade-offs linked toxicant resistance. Our results revealed substantial differences between populations. SC demonstrated dose-dependent changes hypoxia, while exhibited muted transcriptional Interestingly, showed significant did not exhibit notable epigenetic alterations. These findings suggest toxicant-adapted face molecular environmental stress, potentially impacting survive coastal habitats. Further research is needed elucidate functional implications these modifications role adaptive stress responses.

Language: Английский

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