From Cell to Organ: Exploring the Toxicological Correlation of Organophosphorus Compounds in Living System

Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 154049 - 154049

Published: Jan. 1, 2025

Language: Английский

Role of Kynurenine and Its Derivatives in Liver Diseases: Recent Advances and Future Clinical Perspectives

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 968 - 968

Published: Jan. 24, 2025

Liver health is integral to overall human well-being and the pathogenesis of various diseases. In recent years, kynurenine its derivatives have gradually been recognized for their involvement in pathophysiological processes, especially regulation liver diseases, such as acute injury, non-alcoholic fatty disease, cirrhosis, cancer. Kynurenine are derived from tryptophan, which broken down by enzymes indoleamine 2,3-dioxygenase (IDO) tryptophan (TDO), converting essential amino acid into (KYN) other downstream metabolites, kynurenic (KYNA), 3-hydroxykynurenine (3-HK), xanthurenic (XA), quinolinic (QA). can promote activity transcription factor aryl hydrocarbon receptor (AhR), suppress T cell immune modulation, inhibit activation inflammatory signaling pathways, NF-κB anti-inflammatory effects, hepatic stellate cells slow fibrosis progression. Additionally, metabolites influence progression diseases modulating gut microbiota. Therefore, this review, we summarize explore mechanisms regulate help develop new diagnostic or prognostic biomarkers effective therapies targeting pathway disease treatment.

Language: Английский

Exposure to malathion impairs learning and memory of zebrafish by disrupting cholinergic signal transmission, undermining synaptic plasticity, and aggravating neuronal apoptosis

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 137391 - 137391

Published: Jan. 1, 2025

Language: Английский