
Atherosclerosis, Journal Year: 2025, Volume and Issue: unknown, P. 119238 - 119238
Published: May 1, 2025
Temperature extremes are one facet of global warming caused by climate change. They have a broad impact on population health globally. Due to specific individual- and area-level factors, some subgroups the at particular risk. Observational data has demonstrated that association between temperature mortality cardiovascular is U- or J-shaped. This means beyond an optimal temperature, both low high temperatures increase In addition, there emerging epidemiological showing change-related fluctuations may be particularly challenging for health. Biological plausibility these observations comes from effect cold, heat, risk factors disease. Shared mechanisms heat cold adaptation include sympathetic activation, changes in vascular tone, increased cardiac strain, inflammatory prothrombotic stimuli. The confluence can result demand ischemia and/or atherosclerotic plaque rupture. conclusion, public individual-level measures should taken protect susceptible populations, such as patients with pre-existing disease, adverse effects non-optimal temperatures. review aims provide overview disease through lens pathophysiology observational data. It also highlights meteorological aspects, gives insight interplay air pollution, touches upon social dimensions change, tries give brief outlook into what expect future.
Language: Английский