Nitroaromatic Compounds from Secondary Nitrate Formation and Biomass Burning Are Major Proinflammatory Components in Organic Aerosols in Guangzhou: A Bioassay Combining High-Resolution Mass Spectrometry Analysis

Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 57(51), P. 21570 - 21580

Published: Nov. 21, 2023

The limited characterization and detection capacity of unknown compounds hinder our understanding the molecular composition toxic in PM2.5. present study applied Fourier transform ion cyclotron resonance mass spectrometry coupled with negative positive electrospray ionization sources (ESI–/ESI+ FT-ICR-MS) to probe characteristics dynamic formation processes effective proinflammatory components organic aerosols (OAs) PM2.5 Guangzhou for one year. We detected abundant molecules OAs, mainly classified as CHON (compounds composed C, H, O, N atoms) elemental nitroaromatic (NACs) structures. From perspective process, we discovered that these molecules, especially NACs, were largely driven by secondary nitrate biomass burning (in emission source), well SO2 atmospheric evolution). In addition, results indicated had replaced primary main contributing source OAs. This highlights importance community measures control production derived from urban areas.

Language: Английский

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Secondary formation of oxygenated and nitrated polycyclic aromatic compounds under stagnant weather conditions: Drivers and seasonal variation

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 929, P. 172487 - 172487

Published: April 16, 2024

Language: Английский

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Maternal PM2.5 exposure is associated with preterm birth and gestational diabetes mellitus, and mitochondrial OXPHOS dysfunction in cord blood

Environmental Science and Pollution Research, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 10, 2024

Abstract Maternal exposure to fine particulate matter (PM 2.5 ) is associated with adverse pregnancy and neonatal health outcomes. To explore the mechanism, we performed mRNA sequencing of cord blood. From an ongoing prospective cohort, Air Pollution on Pregnancy Outcome (APPO) study, 454 pregnant women from six centers between January 2021 June 2022 were recruited. Individual PM was calculated using a time-weighted average model. In APPO age-matched blood samples High (˃15 ug/m 3 ; n = 10) Low (≤ 15 30) groups randomly selected for sequencing. After selecting genes differential expression in two ( p -value < 0.05 log2 fold change > 1.5), pathway enrichment analysis performed, mitochondrial analyzed MitoCarta3.0. The risk preterm birth (PTB) increased every 5 µg/m increase second trimester (odds ratio 1.391, 0.019) after adjusting confounding variables. gestational diabetes mellitus (GDM) 1.238, 0.041) third 1.290, 0.029), entire 1.295, 0.029). mRNA-sequencing showed that related activity (FAM210B, KRT1, FOXO4, TRIM58, FBXO7) PTB-related (ADIPOR1, YBX1, OPTN, NFkB1, HBG2) upregulated group. addition, high affected oxidative phosphorylation (OXPHOS) proteins electron transport chain, subunit OXPHOS. These results suggest during may PTB GDM, dysregulate genes. Alterations OXPHOS by occur not only infants but also normal newborns. Further studies larger sample sizes are required.

Language: Английский

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Source apportionment of particle-bound polycyclic aromatic hydrocarbons (PAHs), oxygenated PAHs (OPAHs), and their associated long-term health risks in a major European city

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 951, P. 175416 - 175416

Published: Aug. 12, 2024

Language: Английский

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Evaluating the presence of SARS-CoV-2 RNA in the particulate matters during the peak of COVID-19 in Padua, northern Italy

The Science of The Total Environment, Journal Year: 2021, Volume and Issue: 784, P. 147129 - 147129

Published: April 16, 2021

Language: Английский

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Multi-omics analysis to reveal disorders of cell metabolism and integrin signaling pathways induced by PM2.5

Journal of Hazardous Materials, Journal Year: 2021, Volume and Issue: 424, P. 127573 - 127573

Published: Oct. 27, 2021

Language: Английский

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Reduction in polycyclic aromatic hydrocarbon exposure in Beijing following China’s clean air actions

Science Bulletin, Journal Year: 2024, Volume and Issue: 69(20), P. 3283 - 3290

Published: Aug. 16, 2024

Exposure to polycyclic aromatic hydrocarbons (PAHs) in the Chinese population was among highest globally and associated with various adverse effects. This study examines impact of China's two-phase clean air initiatives, namely Air Pollution Prevention Control Action Plan (APPCAP) 2013-2017 Blue-Sky Defense War (BSDW) 2018-2020, on PAH levels human exposures Beijing. To evaluate effects APPCAP, we measured 16 PAHs 287 PM

Language: Английский

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Atmospheric occurrences and bioavailability health risk of PAHs and their derivatives surrounding a non-ferrous metal smelting plant.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 470, P. 134200 - 134200

Published: April 5, 2024

Language: Английский

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The leading role of adsorbed lead in PM2.5-induced hippocampal neuronal apoptosis and synaptic damage

Journal of Hazardous Materials, Journal Year: 2021, Volume and Issue: 416, P. 125867 - 125867

Published: April 21, 2021

Language: Английский

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Analytical methods for organosulfate detection in aerosol particles: Current status and future perspectives

The Science of The Total Environment, Journal Year: 2021, Volume and Issue: 784, P. 147244 - 147244

Published: April 21, 2021

Language: Английский

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