Toxic Potencies of Particulate Matter from Typical Industrial Plants Mediated with Acidity via Metal Dissolution

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(15), P. 6736 - 6743

Published: April 2, 2024

Acidity is an important property of particulate matter (PM) in the atmosphere, but its association with PM toxicity remains unclear. Here, this study quantitively reports effect acidity level on via pH-control experiments and cellular analysis. Oxidative stress cytotoxicity potencies acidified samples at pH 1–2 were up to 2.8–5.2 2.1–13.2 times higher than those 8–11, respectively. The toxic from real-world smoke plumes 2.3 9.1–18.2 greater 5.6, demonstrating a trend similar that samples. Furthermore, impact was manifested by promoting metal dissolution. dramatic increase 2–3 orders magnitude water-soluble content dominated variation toxicity. significant correlation between sulfate, value, Fe, IC20, EC1.5 (p < 0.05) suggested acidic sulfate could enhance dissolving insoluble metals. findings uncover superficial adverse health outcomes epidemiological research highlight control wet plume emissions mitigate effects acidity.

Language: Английский

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High Magnetic Property and Toxicity of Particulate Matter Generated during Welding and Cutting Processes

Environment & Health, Journal Year: 2024, Volume and Issue: 2(6), P. 381 - 389

Published: March 19, 2024

Magnetic particulate matter (PM) has raised increasing concern due to its abundant presence in ambient air and negative health impact. However, there is still a lack of comprehensive understanding their emission sources toxicities. We here report the observation high magnetic property toxicity PM generated during typical welding cutting processes. Magnetite, formed high-temperature operation with less oxygen pressure, was revealed be major contributor. The averaged saturation magnetization susceptibility values fine (PM2.5) from processes are 1.4–4.2 times greater than those emitted other unintended sources, including iron steel plants brake wear, while they 2.0–5.7 for Furthermore, PM2.5 nearly 3.5–4.5 more neurovirulent 2.1–7.0 likely induce oxidative stress nerve cells lines. Moreover, all these exhibit effects atmospheric collected Shanghai urban regions. These new findings suggest that appropriate occupational protection measures should implemented process reduce adverse impacts.

Language: Английский

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Aerosol Toxicokinetics: A Framework for Unraveling Toxicological Dynamics from Air to the Body

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

Exposure to atmospheric aerosols threatens human health and is yet be effectively addressed globally. Aerosol toxicity strongly depends upon components whose chemical profiles concentrations can constantly evolve throughout transformation, inhalation, distribution, metabolism, excretion. Despite the abundant studies on aerosol their toxic effects, dynamics in component related biological effects from air body remain unclear. Here, we propose a conceptual toxicokinetic framework mathematically deduce bioavailable concentration changing bulk of constituents atmosphere. The single or multiple are further predicted via toxicodynamic modeling according concentrations. Atmospheric composition turn regulated by risk-based guidelines, aiming alleviate vivo effects. This perspective demonstrates how serial toxicokinetic-toxicodynamic equations bridge knowledge gap between ambient associated bodies. prediction an inhalation also allows connecting with exposomes aggregate exposure pathways. We call for development model validity integrate quantitative adverse outcome pathways apply exposure-disease modeling, providing novel insights into quality policymaking public management.

Language: Английский

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Review of health effects driven by aerosol acidity: Occurrence and implications for air pollution control

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 955, P. 176839 - 176839

Published: Oct. 16, 2024

Language: Английский

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Absence of a Causal Link between Elemental Carbon Exposure and Short-Term Respiratory Toxicity in Human-Derived Organoids and Cellular Models

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 27, 2024

Black carbon or elemental (EC) in the atmosphere plays an ambiguous role acute respiratory toxic effects. Here, we evaluate contribution of EC to short-term toxicity (including cytotoxicity and oxidative stress potency) fine particulate matter (PM2.5) on human tract using vitro airway organoids cell lines. The potency per unit mass, including char soot, is more than 2 orders magnitude lower that polycyclic aromatic hydrocarbons (PAHs), which are coemitted from incomplete combustion. contributes approximately 1 order less PM2.5 PAHs, despite its positive associations with PM2.5-induced (p < 0.0001). Furthermore, PAHs contribute 71.9 ± 12.2% 61.9 32.8% overall emitted typical burning solid liquid fuels, respectively, while significantly correlates content (r = 0.94, p 0.002). Hence, not a cause inducing toxicity, likely attributed PAHs. These findings provide causal evidence for understanding health risks associated exposure further benefit establishing efficient air pollution control policies.

Language: Английский

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Magnetite nanoparticles from representative coal fired power plants in China: Dust removal capture and their final atmospheric emission

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 952, P. 175950 - 175950

Published: Aug. 31, 2024

Language: Английский

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Nicotinohydrazide derived hydrazone ligated vanadium(V) complex: Supramolecular assembly and quantification of intermolecular interactions

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1321, P. 139858 - 139858

Published: Aug. 30, 2024

Language: Английский

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Size-Dependent Elemental Composition in Individual Magnetite Nanoparticles Generated from Coal-Fired Power Plant Regulating Their Pulmonary Cytotoxicity

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

High-resolution characterization of magnetite nanoparticles (MNPs) derived from coal combustion activities is crucial to better understand their health-related risks. In this study, size distribution and elemental composition individual MNPs various fly ashes (CFAs) collected a representative coal-fired power plant were analyzed using single-particle inductively coupled plasma time-of-flight mass spectrometry technique. Majority (61-80%) identified as multimetal (mm)-MNPs, while the contribution single metal (sm)-MNPs total increased throughout all CFAs, reaching highest in ash escaped through stack (EFA). Among Fe-rich MNPs, Fe-sole Fe-Al matrices predominant, important carrier for toxic metals, with contributions metals therein. Toxic potency results showed that oxidative stress induced by was 1.2-2.2 times greater than those <1 μm fractions reduction cell viability no significant difference, elucidating these can induce more distinct compared toxicity. Based on structural equation model, MNP both directly indirectly regulate potency, indirect regulation size-dependent including metals. sm-MNPs Fe-sole, Fe-Cr, Fe-Zn stress, whereas Cr, Zn, Pb associated Fe-Al, Si-Fe, Al-Fe effects viability.

Language: Английский

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Unequal toxic effects of size-segregated single particles emitted from typical industrial plants, vehicles, and road dust

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 480, P. 136419 - 136419

Published: Nov. 5, 2024

Language: Английский

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