Exposure to Polystyrene Nanoplastics Compromise Ovarian Reserve Function and Endometrial Decidualization in Early Pregnant Mice

Journal of Applied Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

ABSTRACT In the environment, nanoplastics (NPs) have been shown to adversely impact reproductive health, yet research on their effects during early pregnancy is scarce. This study investigated of NPs endometrial decidualization in pregnant mice and fertility. Female were administered polystyrene (PS‐NPs) orally for 90 days before pregnancy. Our findings indicated that PS‐NPs exposure decreased live birth rate neonatal crown‐rump length. Decreased embryo implantation sites uterine wet weight observed post exposure. Histological examination revealed structural defects uteri a significant reduction follicular count across all stages PS‐NPs‐treated groups. Serum levels estradiol (E 2 ) progesterone (P) elevated, while follicle‐stimulating hormone (FSH) luteinizing (LH) diminished post‐exposure. Additionally, upregulated expression marker HOXA10 decidua. conclusion, our results suggest may disrupt disruption likely due perturbation hormonal balance within hypothalamic–pituitary–ovary including FSH, LH, E , P levels. These alterations arrest development, consequently leading detrimental outcomes compromised conditions. provided new perspective understanding possible microplastics female

Language: Английский

---

Bioelectrochemistry promotes microbial activity and accelerates wastewater methanogenesis in anaerobic digestion under combined exposure to antibiotics and microplastics

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 138053 - 138053

Published: March 1, 2025

Language: Английский

---

Correcting microplastic pollution and risk assessment in Chinese watersheds

Environmental Pollution, Journal Year: 2025, Volume and Issue: 374, P. 126241 - 126241

Published: April 11, 2025

Language: Английский

---

Towards harmonized ecotoxicological effect assessment of micro- and nanoplastics in aquatic systems

Environmental Pollution, Journal Year: 2024, Volume and Issue: 366, P. 125504 - 125504

Published: Dec. 9, 2024

Micro- and nanoplastics are globally important environmental pollutants. Although research in this field is continuously improving, there a number of uncertainties, inconsistencies methodological challenges the effect assessment micro- nanoparticles freshwater systems. The current understanding adverse effects partly biased by use non-relevant particle types, unsuitable test setups environmentally unrealistic dose metrics, which does not take into account realistic processes uptake consequent effects. Here we summarize state art compiling most recent with aim to highlight gaps further necessary steps towards more harmonized testing In particular, ecotoxicological scenarios need mirror diversity bioavailability. Harmonized should include different pathways, exposures comparisons natural reference particles. Effect assessments differentiate direct physical effects, such as lesions toxicity caused polymer, from indirect alterations ambient conditions leaching, change turbidity, food dilution organisms' behavior. Implementation these suggestions can contribute harmonization effective, evidence-based nanoplastics.

Language: Английский

---

Experimental inconsistencies undermine accurate characterization of microplastics and identification of environmental drivers:a metadata analysis in Chinese aquatic environment

Ecological Indicators, Journal Year: 2024, Volume and Issue: 170, P. 113053 - 113053

Published: Dec. 28, 2024

Language: Английский

---