Continuous Hydrogenation of Nitriles to Primary Amines with High Selectivity in Flow by Using Raney Cobalt DOI
Hongbo Yu, Weixing Ming, Qi Zhang

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(15)

Published: April 15, 2024

Abstract Primary amines produced by selective catalytic hydrogenation of cyano compounds are widely used as basic chemicals, but due to the complexity mechanism and inefficient mass transfer intermittent reaction, process tends produce secondary tertiary undesirable by‐products. In this research, a continuous system employing micropacked‐bed reactor (μPBR) was established for 3‐ethylaminopropionitrile (3‐EAPN) synthesize N‐ethyl‐1,3‐propanediamine (3‐EAPA). Under optimal experimental conditions using Raney cobalt catalyst, complete conversion 3‐EAPN achieved, high selectivity 99.6 % primary amine (3‐EAPA) obtained. On basis, extended with other different structures substrates, demonstrating general applicability catalyst in μPBR various nitriles.

Language: Английский

Continuous Hydrogenation of Nitriles to Primary Amines with High Selectivity in Flow by Using Raney Cobalt DOI
Hongbo Yu, Weixing Ming, Qi Zhang

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(15)

Published: April 15, 2024

Abstract Primary amines produced by selective catalytic hydrogenation of cyano compounds are widely used as basic chemicals, but due to the complexity mechanism and inefficient mass transfer intermittent reaction, process tends produce secondary tertiary undesirable by‐products. In this research, a continuous system employing micropacked‐bed reactor (μPBR) was established for 3‐ethylaminopropionitrile (3‐EAPN) synthesize N‐ethyl‐1,3‐propanediamine (3‐EAPA). Under optimal experimental conditions using Raney cobalt catalyst, complete conversion 3‐EAPN achieved, high selectivity 99.6 % primary amine (3‐EAPA) obtained. On basis, extended with other different structures substrates, demonstrating general applicability catalyst in μPBR various nitriles.

Language: Английский

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