Hydrolysis, Ligand Exchange, and Redox Properties of Vanadium Compounds: Implications of Solution Transformation on Biological, Therapeutic, and Environmental Applications

Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

Vanadium is a transition metal with important industrial, technological, biological, and biomedical applications widespread in the environment living beings. The different reactions that vanadium compounds (VCs) undergo presence of proteins, nucleic acids, lipids metabolites under mild physiological conditions are reviewed. In present naturally or through anthropogenic sources, latter having an environmental impact caused by dispersion VCs atmosphere aquifers. has versatile chemistry interconvertible oxidation states, variable coordination number geometry, ability to form polyoxidovanadates various nuclearity structures. If VC added water-containing it can hydrolysis, ligand-exchange, redox, other types changes, determined speciation vanadium. Importantly, solution likely differ from introduced into system varies concentration. Here, hydrolytic ligand-exchange chemical reactions, influence pH, concentration, salt, specific solutes, biomolecules, on described. One our goals this work highlight need for assessment speciation, so beneficial toxic species might be identified mechanisms action elucidated.

Language: Английский

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Optimizing Therapeutics for Intratumoral Cancer Treatments: Antiproliferative Vanadium Complexes in Glioblastoma

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 994 - 994

Published: Jan. 24, 2025

Glioblastoma, an aggressive cancer, is difficult to treat due its location, late detection, drug resistance, and poor absorption of chemotherapeutics. Intratumoral administration offers a promising potential treatment alternative with localized delivery minimal systemic toxicity. Vanadium(V) coordination complexes, incorporating Schiff base catecholate ligands, have shown effects as antiproliferative agents tunable efficacy reactivity, stability, steric bulk, hydrophobicity, uptake, toxicity optimized for the intratumoral vehicle. A new series oxovanadium(V) base–catecholate complexes were synthesized characterized using nuclear magnetic resonance (NMR), UV-Vis, infrared spectroscopy mass spectrometry. Stability under physiological conditions was assessed via UV-Vis spectroscopy, activity evaluated in T98G glioblastoma SVG p12 normal glial cells viability assays. The newly [VO(3-tBuHSHED)(TIPCAT)] complex more stable (t1/2 ~ 4.5 h) had strong (IC50 1.5 µM), comparing favorably current lead compound, [VO(HSHED)(DTB)]. structural modifications enhanced bulk through substitution iso-propyl tert-butyl groups. improved properties attributed hindrance associated catecholato well formation non-toxic byproducts upon degradation. emerges candidate therapy by demonstrating stability greater selectivity, which highlights role strategic ligand design developing therapies resistant cancers. In reporting class compounds effective against cells, we describe generally desirable that drugs being developed should have.

Language: Английский

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Anticancer perspectives of vanadium complexes

Inorganic Chemistry Communications, Journal Year: 2024, Volume and Issue: 161, P. 112014 - 112014

Published: Jan. 5, 2024

Language: Английский

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Green route synthesis of transition metal doped V2O5 nanoparticles, with emerging biomedical applications

Results in Chemistry, Journal Year: 2024, Volume and Issue: 7, P. 101373 - 101373

Published: Jan. 1, 2024

In this proposed work we synthesized the pristine V2O5 nanoparticles and Ag (3.2 %, 14.5 23.4 %), Cd (5.8 23.5 35.7 %) Ru doped (4.9 20.7 32 using vigna radiata extract. The were characterized by various techniques like UV-DRS, FT-IR, XRD, FE-SEM HR-TEM. antibacterial activities of studied bacterial strains such as Staphylococcus aures (S.aureus), Streptococcus pneumoniea (S. pneumoniea), Pseudomonas aeruginosae (P. aeruginosae), Klebsiella (K. pneumoniea) Escherichia coli (E.coli). Among potential bacterium growth inhibition 99 % for S.aureus was observed CV-5. binding efficiency with biomolecule BSA UV–visible absorption emission spectral techniques. It found that there is a interaction between them constant values are in range from 104 to 105 M−1. quenching rate (kq) value bigger than maximum diffusion biomolecules 2.0 x 1010M−1s−1 suggesting static type. glucose oxidation studies lower high current density 440 mA/cm2 occurred NPs.

Language: Английский

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Halogenated non-innocent vanadium(v) Schiff base complexes: chemical and anti-proliferative properties

New Journal of Chemistry, Journal Year: 2024, Volume and Issue: 48(29), P. 12893 - 12911

Published: Jan. 1, 2024

Halogenated non-innocent vanadium( v ) Schiff base mono-substituted catecholates have a low stability and anti-proliferative properties similar to vanadate. A linear correlation between complex redox potential the catechol p K was observed.

Language: Английский

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Synthesis, crystal structure, computational and solution studies of a new phosphotetradecavanadate salt. Assessment of its effect on U87 glioblastoma cells

Journal of Inorganic Biochemistry, Journal Year: 2025, Volume and Issue: 269, P. 112882 - 112882

Published: March 9, 2025

Language: Английский

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Synthesis, structure, stability, lipophilicity and bio-relevant activities of new heteroleptic oxidovanadium(V) complexes

Journal of Inorganic Biochemistry, Journal Year: 2025, Volume and Issue: 270, P. 112939 - 112939

Published: May 1, 2025

Language: Английский

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Interaction of Vanadium Complexes with Proteins: Revisiting the Reported Structures in the Protein Data Bank (PDB) since 2015

Molecules, Journal Year: 2023, Volume and Issue: 28(18), P. 6538 - 6538

Published: Sept. 9, 2023

The structural determination and characterization of molecules, namely proteins enzymes, is crucial to gaining a better understanding their role in different chemical biological processes. continuous technical developments the experimental computational resources X-ray diffraction (XRD) and, more recently, cryogenic Electron Microscopy (cryo-EM) led an enormous growth number structures deposited Protein Data Bank (PDB). Bioinorganic chemistry arose as relevant discipline biology therapeutics, with massive studies reporting effects metal complexes on systems, vanadium being one systems addressed. In this review, we focus interactions compounds (VCs) proteins. Several types binding are established between VCs proteins/enzymes. Considering that V-species bind may differ from those initially added, mentioned techniques pivotal clarifying nature variety proposing mechanisms involved either enzymatic inhibition or catalysis. As such, provide account available information bound obtained by both XRD and/or cryo-EM, mainly exploring recent structures, particularly containing organic-based complexes.

Language: Английский

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Interaction of V^IVO–8-hydroxyquinoline species with RNase A: the effect of metal ligands in the protein adduct stabilization

Inorganic Chemistry Frontiers, Journal Year: 2023, Volume and Issue: 10(17), P. 5186 - 5198

Published: Jan. 1, 2023

The interaction of [V IV O(8-HQ) 2 ] (8-HQ – = 8-hydroxyquinolato) with RNase A occurs upon binding Glu111 to O(8-HQ)(H O)] + moiety and release one 8-HQ . It is influenced not only by the stability V species but also nature ligand.

Language: Английский

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Stabilization and Binding of [V₄O₁₂]⁴⁻ and Unprecedented [V₂₀O₅₄(NO₃)]ⁿ⁻ to Lysozyme upon Loss of Ligands and Oxidation of the Potential Drug V^IVO(acetylacetonato)₂

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(50)

Published: Sept. 28, 2023

High-resolution crystal structures of lysozyme in the presence potential drug VIV O(acetylacetonato)2 under two different experimental conditions have been solved. The crystallographic study reveals loss ligands, oxidation to VV and subsequent formation adducts protein with polyoxidovanadates: [V4 O12 ]4- , which interacts non-covalently, unprecedented [V20 O54 (NO3 )]n- is covalenty bound side chain an aspartate residue symmetry related molecules.

Language: Английский

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