Disulfide-Bridged Cationic Dinuclear Ir(III) Complex with Aggregation-Induced Emission and Glutathione-Consumption Properties for Elevating Photodynamic Therapy DOI Creative Commons

Meijia Huang,

Jie Cui,

Qi Wu

et al.

Inorganic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 2, 2024

The ability of photosensitizers (PSs) to generate reactive oxygen species (ROS) is crucial for photodynamic therapy (PDT). However, many traditional PSs face the drawbacks that aggregation-caused quenching (ACQ) and highly expressed glutathione (GSH) in tumor microenvironment seriously limit their ROS generation ability. Herein, we report two cationic dinuclear iridium complexes, Ir–C–C–Ir Ir–S–S–Ir, which possess aggregation-induced emission (AIE). Ir–S–S–Ir was constructed GSH consumption by introducing a disulfide linkage between auxiliary ligands with imine units. Quantum chemical calculations revealed degenerate states, provide more channels singlet-to-triplet exciton transitions, then intersystem crossing rate increased due heavy atom effect sulfur atoms. production experiments indicated singlet yield 33 times than ACQ mononuclear complex Ir–C. Most importantly, consumed through thiol–disulfide exchange reaction, as demonstrated mass spectrometry high-performance liquid chromatography. Cell testified consumes cells, possesses good capacity, exhibits an extraordinary PDT effect. This first AIE GSH-consuming function.

Language: Английский

Chemiluminescent transition metal complexes: Mechanisms and applications DOI
Jinghui Zhu,

Mingrui Gu,

Yahui Chen

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 530, P. 216495 - 216495

Published: Feb. 5, 2025

Language: Английский

Citations

1
Advances in phototheranostic agents: From imaging to targeted therapy DOI

M. Samadzadeh,

Arezoo Khosravi, Atefeh Zarepour

et al.

Materials Today Chemistry, Journal Year: 2025, Volume and Issue: 43, P. 102516 - 102516

Published: Jan. 1, 2025

Language: Английский

Citations

0
Advanced strategies in the design of Ir(III) biscyclometalated complexes for PDT DOI
Juan Sanz-Villafruela, Arancha Carbayo, Marta Martı́nez-Alonso

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 534, P. 216572 - 216572

Published: March 14, 2025

Language: Английский

Citations

0
Synergistic Comprehensive Activation Methods for Dual‐Modality PDT and Hypoxia‐Triggered Chemotherapy Guided by NIR‐II Imaging beyond 1700 nm in Deep Tumors DOI
Hao Chen, Sheng-Nan Liu, Wang Wang

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Abstract Although photodynamic therapy (PDT) holds great promise for applications in cancer treatment, it has limited effectiveness against deep hypoxic tumors. Moreover, the lack of visualization guidance precision theranostics poses additional challenges, hindering its broader clinical adoption. By combining NIR‐IIc (1800 nm) imaging with internally and externally activatable dual‐modality PDT hypoxia‐triggered chemotherapy, this study proposes a conceptual framework to overcome these limitations. This approach involves use photoswitchable lanthanide‐doped nanoparticles featuring Tm 3+ ‐activated upconversion/downshifting emissions coupled carboxyl‐terminated Ir(III) complex‐based Type I/II photosensitizer form nanophotosensitizer. The findings demonstrate that system enabled upon 808/980 nm excitation while selectively activating external under 980 irradiation, thereby ensuring accurate minimizing phototoxicity risk. complex conjugates luminol self‐illuminating photosensitizer, which can respond elevated H 2 O levels tumor microenvironment, effectively catalyzing chemiluminescence‐assisted PDT. aggravates hypoxia, turn activates hypoxia‐activatable prodrugs like tirapazamine, resulting synergistic antitumor effect. With imaging‐guided PDT, introduces groundbreaking unites significantly advancing precise effective treatment

Language: Английский

Citations

0
Disulfide-Bridged Cationic Dinuclear Ir(III) Complex with Aggregation-Induced Emission and Glutathione-Consumption Properties for Elevating Photodynamic Therapy DOI Creative Commons

Meijia Huang,

Jie Cui,

Qi Wu

et al.

Inorganic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 2, 2024

The ability of photosensitizers (PSs) to generate reactive oxygen species (ROS) is crucial for photodynamic therapy (PDT). However, many traditional PSs face the drawbacks that aggregation-caused quenching (ACQ) and highly expressed glutathione (GSH) in tumor microenvironment seriously limit their ROS generation ability. Herein, we report two cationic dinuclear iridium complexes, Ir–C–C–Ir Ir–S–S–Ir, which possess aggregation-induced emission (AIE). Ir–S–S–Ir was constructed GSH consumption by introducing a disulfide linkage between auxiliary ligands with imine units. Quantum chemical calculations revealed degenerate states, provide more channels singlet-to-triplet exciton transitions, then intersystem crossing rate increased due heavy atom effect sulfur atoms. production experiments indicated singlet yield 33 times than ACQ mononuclear complex Ir–C. Most importantly, consumed through thiol–disulfide exchange reaction, as demonstrated mass spectrometry high-performance liquid chromatography. Cell testified consumes cells, possesses good capacity, exhibits an extraordinary PDT effect. This first AIE GSH-consuming function.

Language: Английский

Citations

0