Journal of Functional Foods,
Journal Year:
2021,
Volume and Issue:
87, P. 104853 - 104853
Published: Nov. 10, 2021
This
study
is
aims
to
evaluate
the
beneficial
effects
of
polyphenols-rich
extracts
from
walnut
green
husk
(WGHP)
on
prevention
obesity,
nonalcoholic
fatty
liver
disease
(NAFLD),
vascular
endothelial
dysfunction
and
colon
tissue
damage
in
rats
fed
high
fat
diet
for
8
weeks.
HPLC
analysis
showed
that
epicatechin,
rutin
caffeic
acid
are
main
components
WGHP.
Administration
WGHP
HF-fed
effectively
prevented
abnormal
body
weight
gain,
lipid
metabolism
disorder,
oxidative
stress
inflammation.
Biochemical
histopathological
observation
consistently
confirmed
protective
NAFLD,
caused
by
HF.
In
addition,
16S
RNA
sequencing
results
reduced
Firmicutes/Bacteroidetes
ratio
reversed
relative
abundance
Ruminococcaceae-UCG-014
Fusicatenibacter.
These
suggest
may
serve
as
a
nutritional
agent
protecting
liver,
cardiovascular
rats.
Frontiers in Nutrition,
Journal Year:
2024,
Volume and Issue:
11
Published: May 3, 2024
Moringa
oleifera
(
M.
)
is
a
natural
plant
that
has
excellent
nutritional
and
medicinal
potential.
leaves
(MOL)
contain
several
bioactive
compounds.
The
aim
of
this
study
was
to
evaluate
the
potential
effect
MOL
polysaccharide
(MOLP)
on
intestinal
flora
in
dextran
sulfate
sodium
(DSS)-induced
ulcerative
colitis
(UC)
mice.
DSS-induced
deemed
be
well-characterized
experimental
model
for
investigating
protective
drugs
UC.
In
study,
we
stimulated
mice
with
DSS
4%
7
days
prepared
high
dose
MOLP
(MOLP-H)
order
its
UC
mice,
comparing
three
groups,
including
control,
model,
+
MOLP-H
(100
mg/kg/day).
At
end
experiment,
feces
were
collected,
changes
analyzed
based
16S
rDNA
throughput
sequencing
technology.
results
showed
Shannon,
Simpson,
observed
species
indices
abundance
decreased
group
compared
control
group.
However,
mentioned
above
increased
According
beta
diversity
analysis,
low
bacterial
distance
between
respectively.
addition,
group,
relative
Firmicutes
Helicobacter
increased,
while
treatment
improves
health
by
enhancing
number
beneficial
organisms,
,
reducing
pathogenic
such
as
.
conclusion,
these
findings
suggest
may
viable
prebiotic
health-promoting
properties.
Biomedicine & Pharmacotherapy,
Journal Year:
2021,
Volume and Issue:
139, P. 111587 - 111587
Published: April 15, 2021
Salvia-Nelumbinis
naturalis
(SNN)
formula
is
a
traditional
Chinese
medicine
prescription,
and
has
been
confirmed
to
be
effective
in
treating
non-alcoholic
steatohepatitis
(NASH),
but
the
underlying
mechanisms
are
still
unknown.
Here
we
showed
that
4-week
SNN
administration
alleviated
methionine-choline-deficiency
(MCD)
diet-induced
hepatic
steatosis
inflammation
as
well
serum
levels
of
alanine
transaminase
(ALT)
increase
C57BL/6
mice.
Fecal
16S
rDNA
sequencing
indicated
altered
structure
gut
microbiota
partially
reversed
dysbiosis.
Simultaneously,
analyzed
fecal
BA
profile
using
liquid
chromatography
coupled
with
triple
quadrupole
mass
spectrometry
(UPLC-TQMS)
-based
metabolomics,
found
modulated
profile,
predominantly
increased
microbiomes
related
species
(e.g.
nordeoxycholic
acid)
which
turn,
activated
farnesoid
X
receptor
(FXR)-fibroblast
growth
factor
15
(FGF15)
signaling
pathway
colon
not
ileum.
The
activation
intestinal
FXR-FGF15
was
accompanied
by
liver
protein
kinase
B
(PKB/Akt)
phosphorylation,
decrease
p-65
subunit
NF-κB
resulting
less
CD68
positive
macrophages,
inflammatory
cytokine
IL-1β
TNF-α
expression.
Our
results
established
link
between
treatment,
microbiota,
NASH,
might
shed
light
into
behind
beneficial
effects
on
thus
provide
evidence
for
clinical
application
SNN.
Journal of Functional Foods,
Journal Year:
2021,
Volume and Issue:
87, P. 104853 - 104853
Published: Nov. 10, 2021
This
study
is
aims
to
evaluate
the
beneficial
effects
of
polyphenols-rich
extracts
from
walnut
green
husk
(WGHP)
on
prevention
obesity,
nonalcoholic
fatty
liver
disease
(NAFLD),
vascular
endothelial
dysfunction
and
colon
tissue
damage
in
rats
fed
high
fat
diet
for
8
weeks.
HPLC
analysis
showed
that
epicatechin,
rutin
caffeic
acid
are
main
components
WGHP.
Administration
WGHP
HF-fed
effectively
prevented
abnormal
body
weight
gain,
lipid
metabolism
disorder,
oxidative
stress
inflammation.
Biochemical
histopathological
observation
consistently
confirmed
protective
NAFLD,
caused
by
HF.
In
addition,
16S
RNA
sequencing
results
reduced
Firmicutes/Bacteroidetes
ratio
reversed
relative
abundance
Ruminococcaceae-UCG-014
Fusicatenibacter.
These
suggest
may
serve
as
a
nutritional
agent
protecting
liver,
cardiovascular
rats.
