Plant derived exosome- like Nanovesicles: an updated overview DOI Creative Commons

D. Subha,

K. Harshnii,

K.G. Madhikiruba

et al.

Plant Nano Biology, Journal Year: 2022, Volume and Issue: 3, P. 100022 - 100022

Published: Dec. 16, 2022

Exosomes are nanovesicles in the size range of 30–150 nm, produced by mammalian and plant cells. They have lipid bilayer enclosing a unique mix biologically active components including proteins, nucleic acids, metabolites lipids, that depend on their source origin. The derived gaining considerable research attention due to ability be absorbed from dietary sources. Their bioactive impart many therapeutic properties them such as anti-tumorigenic, anti-oxidative, anti-inflammatory, hepatoprotective effects tissue regeneration. possibilities using exosomes for drug delivery is also promising. This review focusses biogenesis biological nature plants describes various inherent properties. It sheds light recently developed methods study them. existing challenges exosomal well future prospective highlighted. Overall, it an update advancements which can provide replacement toxic synthetic drugs disease therapy.

Language: Английский

Plant-Derived Extracellular Vesicles and Their Exciting Potential as the Future of Next-Generation Drug Delivery DOI Creative Commons
Faisal A. Alzahrani, Mohammad Imran Khan, Nader Kameli

et al.

Biomolecules, Journal Year: 2023, Volume and Issue: 13(5), P. 839 - 839

Published: May 15, 2023

Plant cells release tiny membranous vesicles called extracellular (EVs), which are rich in lipids, proteins, nucleic acids, and pharmacologically active compounds. These plant-derived EVs (PDEVs) safe easily extractable have been shown to therapeutic effects against inflammation, cancer, bacteria, aging. They promise preventing or treating colitis, alcoholic liver disease, even COVID-19. PDEVs can also be used as natural carriers for small-molecule drugs acids through various administration routes such oral, transdermal, injection. The unique advantages of make them highly competitive clinical applications preventive healthcare products the future. This review covers latest methods isolating characterizing PDEVs, their disease prevention treatment, potential a new drug carrier, with special attention commercial viability toxicological profile, future nanomedicine therapeutics. champions formation task force specializing address global need rigor standardization PDEV research.

Language: Английский

Citations

55
Plant-Derived Exosome-like Nanoparticles for Biomedical Applications and Regenerative Therapy DOI Creative Commons
Andari Sarasati, Muhammad Hidayat Syahruddin, Archadian Nuryanti

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(4), P. 1053 - 1053

Published: March 29, 2023

Plant-derived exosome-like nanoparticles (PDENs) comprise various bioactive biomolecules. As an alternative cell-free therapeutic approach, they have the potential to deliver nano-bioactive compounds human body, and thus lead anti-inflammatory, antioxidant, anti-tumor benefits. Moreover, it is known that Indonesia one of herbal centers world, with abundance unexplored sources PDENs. This encouraged further research in biomedical science develop natural richness plants as a source for welfare. study aims verify PDENs purposes, especially regenerative therapy applications, by collecting analyzing data from latest relevant developments.

Language: Английский

Citations

47
Research status and challenges of plant-derived exosome-like nanoparticles DOI Open Access
Chunmei Bai,

J Ping Liu,

Xumin Zhang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 174, P. 116543 - 116543

Published: April 11, 2024

In recent years, there has been an increasing number of related studies on exosomes. Most have focused exosomes derived from mammals, confirming the important role that play in cell communication. Plants, as a natural ingredient, plant-derived confirmed to similar structures and functions mammalian-derived Plant-derived exosome-like nanoparticles (PELNs) are lipid bilayer membrane nanovesicles containing bioactive constituents such miRNA, mRNA, protein, lipids obtained plant cells, can participate intercellular communication mediate transboundary communication, high bioavailability low immunogenicity, relatively safe, shown maintaining homeostasis preventing, treating variety diseases. this review, we describe biogenesis, isolation purification methods, structural composition, stability, safety, function PELNs challenges. The anti-inflammatory, antioxidant, antitumor drug delivery mainly described, status research exosome Chinese herbal medicines is outlined. Overall, summarized importance latest results field provided theoretical basis for future clinical application PELNs.

Language: Английский

Citations

25
Hydrogel-exosome system in tissue engineering: A promising therapeutic strategy DOI Creative Commons

Ming‐Hui Fan,

Jin-Kui Pi,

Chen‐Yu Zou

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 38, P. 1 - 30

Published: April 23, 2024

Characterized by their pivotal roles in cell-to-cell communication, cell proliferation, and immune regulation during tissue repair, exosomes have emerged as a promising avenue for "cell-free therapy" clinical applications. Hydrogels, possessing commendable biocompatibility, degradability, adjustability, physical properties akin to biological tissues, also found extensive utility engineering regenerative repair. The synergistic combination of hydrogels holds the potential not only enhance efficiency but collaboratively advance repair process. This review has summarized advancements made over past decade research hydrogel-exosome systems regenerating various tissues including skin, bone, cartilage, nerves tendons, with focus on methods encapsulating releasing within hydrogels. It critically examined gaps limitations current research, whilst proposed future directions applications this innovative approach.

Language: Английский

Citations

22
Plant-Derived Exosome-Like Nanoparticles: Emerging Nanosystems for Enhanced Tissue Engineering DOI Creative Commons
Hui Feng, Yue Yang,

Yan Zhang

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 1189 - 1204

Published: Feb. 1, 2024

Abstract: Tissue engineering holds great potential for tissue repair and rejuvenation. Plant-derived exosome-like nanoparticles (ELNs) have recently emerged as a promising avenue in engineering. However, there is an urgent need to understand how plant ELNs can be therapeutically applied clinical disease management, especially regeneration. In this review, we comprehensively examine the properties, characteristics, isolation techniques of ELNs. We also discuss their impact on immune system, compatibility with human body, role To ensure suitability engineering, explore various modification strategies. Additionally, provide insights into progress commercialization industrial perspectives This review aims highlight regenerative medicine by exploring current research landscape key findings. Keywords: plant, nanoparticles, nanomedicine, cartilage, wound, bone

Language: Английский

Citations

19
Exosome-like nanoparticles derived from fruits, vegetables, and herbs: innovative strategies of therapeutic and drug delivery DOI Creative Commons
Bo Zhao,

Hangjuan Lin,

Xinchi Jiang

et al.

Theranostics, Journal Year: 2024, Volume and Issue: 14(12), P. 4598 - 4621

Published: Jan. 1, 2024

Over the past ten years, significant advancements have been made in exploring plant-derived exosome-like nanoparticles (PELNs) for disease therapeutics and drug delivery. PELNs, as inherent nanoscale particles comprised of proteins, lipids, nucleic acids, secondary metabolites, exhibit capacity cellular uptake by human cells. This intercellular interaction transcends biological boundaries, effectively influencing functions animals. PELNs outstanding biocompatibility, low immunogenicity, enhanced safety, environmentally friendly sustainability. article summarized preparation methods characteristics PELNs. It provided a systematic review varied roles derived from fruits, vegetables, herbs The challenges their production application were discussed, future prospects this rapidly evolving field explored.

Language: Английский

Citations

17
Folic acid-modified ginger-derived extracellular vesicles for targeted treatment of rheumatoid arthritis by remodeling immune microenvironment via the PI3K-AKT pathway DOI Creative Commons

Ruina Han,

Dongyang Zhou,

Ning Ji

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 23, 2025

Rheumatoid arthritis (RA), a form of autoimmune inflammation, is marked by enduring synovial inflammation and the subsequent impairment joint function. Despite availability conventional treatments, they are often marred significant side effects associated high costs. Plant-derived extracellular vesicles (PEVs) offer compelling alternative, owing to their abundant availability, affordability, low immunogenicity, biocompatibility, feasibility for large-scale production. These enhance intercellular communication transferring intrinsic bioactive molecules. In our research, we delve into capacity PEVs treat RA, highlighting role ginger-derived (GDEVs). By conjugating GDEVs with folic acid (FA), have developed FA-GDEVs that maintain inherent immunomodulatory properties. designed selectively target M1 macrophages in inflamed joints via folate receptors (FRs). Our vitro findings indicate promote polarization towards reparative M2 macrophage phenotype modulating PI3K-AKT pathway. Further corroboration comes from vivo studies, which demonstrate not only concentrate efficiently affected but also markedly reduce manifestations RA. Synthesizing these findings, it evident emerge as hopeful candidate RA treatment, offering benefits such safety, therapeutic efficacy.

Language: Английский

Citations

5
Plant-derived nanovesicles: Current understanding and applications for cancer therapy DOI Creative Commons
Ngoc Phung Ly, Hwa Seung Han, Myungsuk Kim

et al.

Bioactive Materials, Journal Year: 2022, Volume and Issue: 22, P. 365 - 383

Published: Oct. 20, 2022

Plant-derived vesicles (PDVs) are membranous structures that originate from plant cells and responsible for multiple physiological pathological functions. In the last decade, PDVs have gained much attention their involvement in different biological processes, including intercellular communication defense response, recent scientific evidence has opened a new avenue applications cancer treatment. Nevertheless, remains unknown about these vesicles, current research inconsistent. This review aims to provide comprehensive introduction PDVs, characteristics purification methods, summarize status of potential development therapy.

Language: Английский

Citations

66
Advances in Bioactivity of MicroRNAs of Plant-Derived Exosome-Like Nanoparticles and Milk-Derived Extracellular Vesicles DOI
Dan Li, Xiaolin Yao,

Jianxiong Yue

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2022, Volume and Issue: 70(21), P. 6285 - 6299

Published: May 18, 2022

MicroRNA (miRNA) is a class of small noncoding RNA involved in physiological and pathological processes via the regulation gene expression. Naked miRNAs are unstable liable to degradation by RNases. Exosome-like nanoparticles (ELNs) secreted plants extracellular vesicles (EVs) found milk abundant miRNAs, which can be carried ELNs EVs target cells exert their bioactivities. In this review, we describe current understanding plant EVs, summarize important roles inflammation, intestinal barrier, tumors, infantile immunological functions, also discuss adverse effect EV on human health. Additionally, prospect recent challenges centered around ELN for interventional applications provide insights grain-derived use Overall, transfer mitigate status recipient mediating expression genes but may some side effects. More studies required elucidate in-depth potential effects

Language: Английский

Citations

57
Plant-Derived Exosomes as a Drug-Delivery Approach for the Treatment of Inflammatory Bowel Disease and Colitis-Associated Cancer DOI Creative Commons
Ying Cai,

Luoxin Zhang,

Youjian Zhang

et al.

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(4), P. 822 - 822

Published: April 8, 2022

Inflammatory bowel disease (IBD) is a chronic recurrent intestinal and includes Crohn's (CD) ulcerative colitis (UC). Due to the complex etiology of colitis, current treatments IBD are quite limited mainly concentrated on remission disease. In addition, side effects conventional drugs body cannot be ignored. also has certain relationship with colitis-associated cancer (CAC), inflammatory cells can produce large number tumor-promoting cytokines promote tumor progression. recent years, exosomes from plants have been found ability load target intestine great potential for treatment diseases. This plant-derived exosome-targeting delivery system chemical or nucleic acid deliver them sites stably efficiently. review summarizes pathophysiological characteristics CAC as well application prospect plant in CAC.

Language: Английский

Citations

53