Brain targeted peptide-functionalized chitosan nanoparticles for resveratrol delivery: Impact on insulin resistance and gut microbiota in obesity-related Alzheimer's disease

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 310, P. 120714 - 120714

Published: Feb. 18, 2023

Language: Английский

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Four Different Structural Dietary Polyphenols, Especially Dihydromyricetin, Possess Superior Protective Effect on Ethanol-Induced ICE-6 and AML-12 Cytotoxicity: The Role of CYP2E1 and Keap1-Nrf2 Pathways

Journal of Agricultural and Food Chemistry, Journal Year: 2023, Volume and Issue: 71(3), P. 1518 - 1530

Published: Jan. 13, 2023

Polyphenols have received attention as dietary supplements for the relief of alcoholic liver disease (ALD) due to various bioactivities. Ethanol-induced rat small intestinal epithelial cell 6 (IEC-6) and alpha mouse 12 (AML-12) models were pretreated with four polyphenols different structures explore their effects on cytotoxicity potential protective mechanisms. The results showed that had functions inhibit ethanol-induced AML-12 IEC-6 damage oxidative stress, restore permeability tight junction gene expression. Especially, dihydromyricetin (DMY) best effect cytotoxicity, followed by apigenin (API). Western blot DMY API ability CYP2E1 Keap1, promote nuclear translocation Nrf2, which might be mechanism attenuate cytotoxicity. Moreover, molecular docking predicted could bind more tightly amino acid residues one inhibitory modes Keap1. This study provided a rationale subsequent alcohol-induced injury in animal new clues bioactive components ALD-protection based gut-liver axis.

Language: Английский

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Galactooligosaccharides: Synthesis, metabolism, bioactivities and food applications

Critical Reviews in Food Science and Nutrition, Journal Year: 2023, Volume and Issue: 64(18), P. 6160 - 6176

Published: Jan. 12, 2023

Prebiotics are non-digestible ingredients that exert significant health-promoting effects on hosts. Galactooligosaccharides (GOS) have remarkable prebiotic and structural similarity to human milk oligosaccharides. They generally comprise two eight sugar units, including galactose glucose, which synthesized from substrate lactose by microbial β-galactosidase. Enzyme sources probiotics received particular interest because of their safety potential synthesize specific structures particularly metabolized intestinal probiotics. Owing advancements in modern analytical techniques, many GOS been identified, vary degree polymerization, glycosidic linkage, branch location. After intake, adjust gut microbiota produce short chain fatty acids, exhibit excellent biological activities. selectively stimulate the proliferation probiotics, inhibit growth adhesion pathogenic bacteria, alleviate gastrointestinal, neurological, metabolic allergic diseases, modulate metabolites production, ion storage absorption. Additionally, safe stable, with high solubility clean taste, thus widely used as food additives. can improve appearance, flavor, texture, viscosity, rheological properties, shelf life, health benefits products. This review systemically covers synthesis, structure identifications, metabolism mechanisms, bioactivities wide applications, focusing recent advances.

Language: Английский

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Lactiplantibacillus plantarum DACNJS22 alleviates benzo(a)pyrene-induced neurobehavioral injury in mice: insights from gut microbiota and short-chain fatty acids

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 105865 - 105865

Published: Jan. 1, 2025

Language: Английский

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Physicochemical Properties, Stability and Texture of Soybean-Oil-Body-Substituted Low-Fat Mayonnaise: Effects of Thickeners and Storage Temperatures

Foods, Journal Year: 2022, Volume and Issue: 11(15), P. 2201 - 2201

Published: July 24, 2022

With the increasing consumer demand for low-fat and low-cholesterol foods, mayonnaise prepared from soybean oil body (SOB) substitute egg yolk has great consumption potential. However, based on previous studies, it was found that stability sensory properties of substituted with SOB were affected due to there being less lecithin containing more water. Therefore, this study investigated effects different ratios xanthan gum, pectin modified starch as stabilizers apparent viscosity, stability, texture microstructure SOB-substituted mayonnaise. It viscosity increased significantly when added in a ratio 2:1:1. Meanwhile, emulsified droplets similar size uniformly dispersed emulsion system thickener formulations. In addition, storage explored. Compared full mayonnaise, had better oxidative bacteriostatic, which is important This provided theoretical basis food industry application SOB. new ideas development

Language: Английский

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Protective Effect of Polyphenols, Protein, Peptides, and Polysaccharides on Alcoholic Liver Disease: A Review of Research Status and Molecular Mechanisms

Journal of Agricultural and Food Chemistry, Journal Year: 2023, Volume and Issue: unknown

Published: March 31, 2023

Alcoholic liver disease (ALD) has emerged as an important public health problem in the world. The polyphenols, protein, peptides, and polysaccharides have attracted attention for prevention or treatment of ALD. Therefore, this paper reviews pathogenesis ALD, relationship between polysaccharides, expounds mechanism gut microbiota on protecting It is mainly found that hydroxyl group polyphenols endows it with antioxidation to protect ALD protection bioactive peptides related amino acid composition. primary structure. Meanwhile, prevent treat by antioxidation, anti-inflammatory, antiapoptosis, lipid metabolism, regulation. This contribution provides updated information response which will not only facilitate development novel components but also future application functional food raw materials be promoted.

Language: Английский

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Alleviating Effect of Lacticaseibacillus rhamnosus 1.0320 Combined with Dihydromyricetin on Acute Alcohol Exposure-Induced Hepatic Impairment: Based on Short-Chain Fatty Acids and Adenosine 5′-Monophosphate-Activated Protein Kinase-Mediated Lipid Metabolism Signaling Pathway

Journal of Agricultural and Food Chemistry, Journal Year: 2023, Volume and Issue: 71(12), P. 4837 - 4850

Published: March 17, 2023

Excessive drinking has been listed by the World Health Organization as fifth major risk factor; especially liver, core organ of alcohol metabolism, is prone to organic lesions. Probiotics have received attention due their bioactivity for liver protection. The beneficial effects probiotics on hosts are related physiological functions. Therefore, based concept second-generation synbiotes, this study explored protective four dietary polyphenols stress tolerance, hydrophobicity, adhesion, and digestive characteristics L. rhamnosus 1.0320. 1.0320 had best synergistic effect with dihydromyricetin (DMY). combination was selected a synbiotic supplement explore acute exposure-induced hepatic impairment. results showed that combined DMY restored intestinal barrier upregulating short-chain fatty acid levels activated adenosine 5′-monophosphate-activated protein kinase-mediated lipid metabolism pathway inhibit oxidative stress, inflammation, accumulation in liver. Furthermore, 109 CFU/mouse/d 50 mg/kg/d gavage were identified optimal doses protection against expose-induced This provides new insights into alleviating alcoholic impairment targeting metabolites through gut-liver axis.

Language: Английский

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Mechanisms of Health Improvement by Lactiplantibacillus plantarum Based on Animal and Human Trials: A Review

Fermentation, Journal Year: 2024, Volume and Issue: 10(2), P. 73 - 73

Published: Jan. 23, 2024

Lactiplantibacillus plantarum is a candidate probiotic that has been included in the list of recommended biological agents for certification by European Food Safety Authority. It found to be widely present acidic-gruel, yogurt, cheese, kefir, kimchi, and so on. In this article, we have reviewed both preclinical human studies related health promoting effects L. published past decade. We could significantly improve intestinal function, oral as well skin health, promote neuro immune regulation, effective against metabolic diseases, etc. primarily enters body through cavity acts on gastrointestinal tract effectively flora. can affect female reproductive endocrine system interaction with estrogen, androgen, insulin, other hormones, body’s allergic reaction immunity regulating Th1/Th2 response. Several prior reports also suggest Gram-positive bacterium production secretion key neurotransmitters neural activators flora directly or indirectly affecting gut–brain axis modulation vagus nerve, cytokines, microbial metabolites, thus relieving stress anxiety symptoms adults. This review first report describing plantarum, aim providing theoretical basis development various beneficial applications plantarum.

Language: Английский

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Low-cholesterol-low-fat mayonnaise prepared from soybean oil body as a substitute for egg yolk: The effect of substitution ratio on physicochemical properties and sensory evaluation

LWT, Journal Year: 2022, Volume and Issue: 167, P. 113867 - 113867

Published: Aug. 11, 2022

Language: Английский

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Probiotic treatment causes sex-specific neuroprotection after traumatic brain injury in mice

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: April 2, 2024

Abstract Background Recent studies have shed light on the potential role of gut dysbiosis in shaping traumatic brain injury (TBI) outcomes. Changes levels and types Lactobacillus bacteria present might impact immune system disturbances, neuroinflammatory responses, anxiety depressive-like behaviors, compromised neuroprotection mechanisms triggered by TBI. Objective This study aimed to investigate effects a daily pan-probiotic (PP) mixture drinking water containing strains plantarum, L. reuteri, helveticus, fermentum, rhamnosus, gasseri , casei administered for either two or seven weeks before inducing TBI both male female mice. Methods Mice were subjected controlled cortical (CCI) injury. Short-chain fatty acids (SCFAs) analysis was performed metabolite measurements. The taxonomic profiles murine fecal samples evaluated using 16S rRNA V1-V3 sequencing analysis. Histological analyses used assess neuroinflammation changes post-TBI, while behavioral tests conducted evaluate sensorimotor cognitive functions. Results Our findings suggest that PP administration modulates diversity composition microbiome increases SCFAs sex-dependent manner. We also observed reduction lesion volume, cell death, microglial macrophage activation after treatment following Furthermore, PP-treated mice show motor function improvements decreases behaviors. Conclusion can mitigate ameliorate behavior deficits These results underscore probiotic interventions as viable therapeutic strategy address TBI-induced impairments, emphasizing need gender-specific approaches.

Language: Английский

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