Published: Jan. 1, 2024
Language: Английский
Published: Jan. 1, 2024
Language: Английский
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 268, P. 132014 - 132014
Published: April 30, 2024
Language: Английский
Citations
6International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141693 - 141693
Published: March 1, 2025
Language: Английский
Citations
0Food Research International, Journal Year: 2025, Volume and Issue: 208, P. 116141 - 116141
Published: March 10, 2025
Language: Английский
Citations
0International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142363 - 142363
Published: March 1, 2025
Language: Английский
Citations
0Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: April 7, 2025
To fully utilize the Citrus aurantium "Changshanhuyou" resource, hypoglycemic effect and mechanisms of action pectin from Changshanhuyou residue (HYP) were studied. HYP considerably inhibited α-glucosidase, suggesting its potent in vitro activity. In streptozotocin-induced type 2 diabetes mellitus (T2DM) mice, significantly increased body weight, survival rate, hexokinase activity, glycogen content decreased fasting blood glucose, oral glucose tolerance, liver glycated serum protein levels. Furthermore, remarkably improved glycolipid metabolism-related indices both liver, IL-6 TNF-α levels serum, antioxidant enzyme activities liver. also modulated mRNA expression key factors (e.g., Akt, PI3K, IRS2, InsR, GLUT4, G6 Pase, PEPCK, AMPK, GS, GSK-3β) short chain fatty acid production abundance beneficial bacteria. Thus, underlying mechanism may involve activation PI3K/Akt, GS/GSK-3β signaling pathways modulation gut microbiota composition.
Language: Английский
Citations
0Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: May 16, 2025
Pectin, a class of dietary fiber, has received increasing attention in recent years for its ameliorative effects on metabolic diseases. However, the structural variability pectin leads to differential these The intrinsic mechanism by which pectin, derived from different sources, differentially influences syndrome interacting with gut microbiota and host metabolism remains elusive warrants thorough investigation. To address this, we investigated HG-type pectins apple, citrus, pomelo phenotypic expressions, inflammatory factors, oxidative stress, serum hormone levels mice syndrome. In addition, sought identify pivotal bacterial species metabolites integrating genomics metabolomics approaches. Our exploration also extended relationship between characteristics pectins, microbiota, findings revealed that three diversely improved mice, correlated their beneficial metabolites. Notably, all were closely associated Bacteroides acidifaciens. Besides, potential mediators therapeutic included Bacteroides, Lactococcus, Lachnoclostriclum apple pectin; Colidextribacter, Lachnospiraceae_NK4A136_group, citrus Mucispirillum pectin. Metabolites such as arachidonic acid, kynurenic lithocholic deoxycholic indoleacetic linked microbes, may serve pectin's benefits. Ultimately, molecular weight, degree esterification, monosaccharide composition significantly influenced outcomes. This study contribute more nuanced understanding can inform targeted nutritional strategies modulate management.
Language: Английский
Citations
0Food Research International, Journal Year: 2024, Volume and Issue: 197, P. 115231 - 115231
Published: Oct. 30, 2024
Language: Английский
Citations
3International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 283, P. 137619 - 137619
Published: Nov. 17, 2024
Language: Английский
Citations
3Food Chemistry, Journal Year: 2024, Volume and Issue: 462, P. 141010 - 141010
Published: Aug. 30, 2024
Language: Английский
Citations
2International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 136902 - 136902
Published: Oct. 1, 2024
Language: Английский
Citations
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