Isothiazoles: Synthetic Strategies and Pharmacological Applications

Royal Society of Chemistry eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 57 - 85

Published: July 24, 2024

Isothiazoles and their derivatives are a well-known class of heterocycles with five members containing sulfur atoms have been widely used in the domains organic chemistry, medicinal pharmaceuticals. The electronegativity heteroatoms (nitrogen sulfur) 1,2-relationships make isothiazoles significant compounds. Among numerous 1,2-azoles, historically recognized as an important compounds various fields. Significant progress has accomplished over last ten years synthesis functionalization isothiazoles, opening up previously undiscovered avenues for chemists to investigate this remarkable Novel methods performing condensation come light, overcoming challenges unstable thiohydroxylamine. There reports new metal-catalyzed procedures producing types broad functional groups. strategies using cross-coupling reactions direct C–H activation documented. Furthermore, additional investigation on versatile heterocyclic scaffold is made possible by development creative structures based isothiazoles.

Language: Английский

Design, Synthesis, and Bioactivity Determination of Novel Malononitrile Derivatives Containing 1,2,3-Triazole

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(35), P. 19274 - 19285

Published: Aug. 26, 2024

Using antifungal agrochemicals as the most economical solution might reduce plant diseases caused by pathogenic fungi, which have a significant negative impact on quality and yield of food worldwide. In this work, 33 compounds (

Language: Английский