Causal relationships between gut microbiota, plasma metabolites, and HIV infection: insights from Mendelian randomization and mediation analysis

Virology Journal, Journal Year: 2024, Volume and Issue: 21(1)

Published: Aug. 30, 2024

Gut dysbiosis and metabolic abnormalities have been implicated in HIV infection. However, the exact causal relationships among gut microbiota, metabolites, infection remain poorly understood. Our study involving Mendelian randomization (MR) mediation analysis aims to unveil these causalities.

Language: Английский

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Jianghua Kucha black tea containing theacrine attenuates depression-like behavior in CUMS mice by regulating gut microbiota-brain neurochemicals and cytokines

Food Research International, Journal Year: 2024, Volume and Issue: 198, P. 115306 - 115306

Published: Nov. 3, 2024

Language: Английский

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Sulforaphane Improves Liver Metabolism and Gut Microbiota in Circadian Rhythm Disorder Mice Models Fed With High‐Fat Diets

Molecular Nutrition & Food Research, Journal Year: 2024, Volume and Issue: 68(21)

Published: Oct. 3, 2024

This study aims to investigate the effect of sulforaphane (SFN) on hepatic metabolism and gut microbiota in a shifted circadian rhythm (CR) mouse model fed with high-fat diet (HFD).

Language: Английский

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Elucidating the gastroprotective mechanisms of Imperata cylindrica Beauv.var. major (Nees) C.E.Hubb through UHPLC-MS/MS and systems network pharmacology

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 13, 2024

Imperata cylindrica Beauv.var. major (Nees) C.E.Hubb., commonly known as BaiMaoGen (BMG), a medicinal and edible traditional Chinese (TCM) herb used in health supplements, has been observed to offer protective effects against gastrointestinal disorders. However, the specific bioactive compounds their molecular mechanisms have not fully elucidated. This study employed ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) systematic network pharmacology analyze identify key active components interactions with biological targets. Thirty-six main compounds, including 3,4-dihydroxybenzoic acid p-hydroxybenzoic acid, were identified analyzed for interaction protein targets using docking dynamic simulations. combined approach highlighted therapeutic pathways involved, particularly PI3K/AKT signaling pathways, providing new insights into basis of BMG's gastroprotective effects. Our findings suggested that complex multi-target action can potentially be harnessed develop effective treatments toxicity.

Language: Английский

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Novel Chlorella pyrenoidosa peptides attenuate weight gain, insulin resistance, and lipid levels in mice fed a high-fat diet

Journal of Functional Foods, Journal Year: 2023, Volume and Issue: 112, P. 105908 - 105908

Published: Dec. 2, 2023

Obesity can cause a wide range of metabolic diseases, but safe and effective treatments are still lacking. Chlorella pyrenoidosa (C. pyrenoidosa) peptides have variety biological activities, their lipid-lowering effects in vivo rarely reported. In this study, one (SISISVAGGGR, T1) the six C. with best gut microbial stability maintenance was screened. Then, anti-obesity different doses T1 (300 mg/Kg/d, 100 mg/Kg/d) were evaluated mice fed high-fat diet (HFD). The results showed that supplementation alleviated HFD-induced weight gain lipid accumulation, reduced fasting blood glucose low-density lipoprotein (LDL) elevated high-density (HDL) levels. improved insulin resistance attenuated hepatic accumulation meta-inflammation both liver adipose tissues obese mice. This study demonstrated novel peptide as potential prebiotic beneficial on obesity related disorders.

Language: Английский

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Dynamics of the Accumulation and Biological Activities of Active Components in the Aerial Parts of Comfrey (Symphytum Officinale L.)

Published: Jan. 1, 2024

Language: Английский

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