The Antidiabetic Potential of Probiotics: A Review

Nutrients, Journal Year: 2024, Volume and Issue: 16(15), P. 2494 - 2494

Published: July 31, 2024

Diabetes has become one of the most prevalent global epidemics, significantly impacting both economy and health individuals. is associated with numerous complications, such as obesity; hyperglycemia; hypercholesterolemia; dyslipidemia; metabolic endotoxemia; intestinal barrier damage; insulin-secretion defects; increased oxidative stress; low-grade, systemic, chronic inflammation. cannot be completely cured; therefore, current research focused on developing various methods to control diabetes. A promising strategy use probiotics for diabetes intervention. Probiotics are a class live, non-toxic microorganisms that can colonize human intestine help improve balance microbiota. In this review, we summarize clinical studies using in humans, along mechanistic conducted animal models. The primary mechanism by which regulate improved integrity, alleviated stress, enhanced immune response, short-chain fatty acid production, etc. Therefore, probiotic supplementation holds great potential prevention management

Language: Английский

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Recent advances in medicinal and edible homologous plant polysaccharides: Preparation, structure and prevention and treatment of diabetes

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 258, P. 128873 - 128873

Published: Dec. 21, 2023

Language: Английский

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Anthocyanin Extracted from Purple Sweet Potato Alleviates Dextran Sulfate Sodium-Induced Colitis in Mice by Suppressing Pyroptosis and Altering Intestinal Flora Structure

Journal of Medicinal Food, Journal Year: 2024, Volume and Issue: 27(2), P. 110 - 122

Published: Jan. 5, 2024

The objective of this study was to examine the impact and underlying mechanisms pelargonidin-3-galactoside (Pg3gal) produced from purple sweet potatoes on colonic inflammation induced by dextran sulfate sodium (DSS) in a murine model ulcerative colitis (UC). C57BL/6J mice were categorized into four groups (

Language: Английский

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Identification and structural characterization of key prebiotic fraction of soluble dietary fiber from grapefruit peel sponge layer and its regulation effect on gut microbiota

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 259, P. 129274 - 129274

Published: Jan. 8, 2024

Language: Английский

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Vinegar-processed Schisandra chinensis polysaccharide ameliorates type 2 diabetes via modulation serum metabolic profiles, gut microbiota, and fecal SCFAs

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 294, P. 139514 - 139514

Published: Jan. 5, 2025

Language: Английский

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Pectin-Type Polysaccharides from Raspberry (Rubus Idaeus L.): Structure Characterization and Anti-Colitis Activity

Published: Jan. 1, 2025

This study explored the structural properties and therapeutic potential of RAP-3A, a novel pectin-type polysaccharide extracted from raspberry (Rubus idaeus L.), in DSS-induced colitis. Structural analysis revealed that with molecular weight 51.03 kDa, is primarily composed backbone 1, 4-galacturonic acid glycan, incorporating 4-linked α-GalpA 2-linked α-Rhap disaccharide repeating unit, branches at C-4 Rhap residue comprising 6-linked β-Galp, β-Galp or 5-linked α-Araf. Remarkably, RAP-3A significantly alleviated colitis symptoms mice, including loss, disease activity index (DAI), histopathological damage. Mechanistically, inhibited TLR4/NF-κB pathway, enhanced intestinal barrier function by upregulating ZO-1 occludin, reduced goblet cell depletion. Furthermore, promoted favorable shift gut microbiota composition, increasing abundance beneficial SCFA-producing bacteria such as Bacteroidales_S24-7, Rikenellaceae, Clostridiales, Oscillospira, Lachnospiraceae, while suppressing pathogenic bacteria, notably Escherichia. GC-MS further confirmed increased fecal SCFAs levels. Collectively, these findings suggested holds considerable for development functional food aimed treatment

Language: Английский

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Effect of bioactive Rosa roxburghii Tratt fruit polysaccharide on the structure and emulsifying property of lactoferrin protein

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 298, P. 140016 - 140016

Published: Jan. 19, 2025

Language: Английский

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Biologically Active Peptides from Corn Gluten Meal Improve Microbiota Disorders Caused by Helicobacter pylori Infection in Mice

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 705 - 705

Published: Feb. 5, 2025

This study investigated the potential effects of corn protein activity peptides (CPAPs) on inflammation response levels and gastrointestinal microbiota in Helicobacter pylori (H. pylori) infection mice. CPAPs significantly up-regulated mRNA expression anti-inflammatory factor IL-10 down-regulated pro-inflammatory factors TGF-β, TLR4, MyD88, NF-κB, indicating that may antagonize H. pylori-induced inflammatory responses by inhibiting NF-κB signaling pathways. Through intervention CPAPs, colonization stomach was reduced. Additionally, structural composition improved, with an increase abundance diversity. These changes positively regulate disorders In addition, PICRUST function prediction intestinal revealed prevent or reduce metabolic brought about pylori, which improve biometabolic pathways modulating composition. conclusion, these findings suggest mitigate induced offering theoretical support for development corn-protein-based functional foods.

Language: Английский

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Medicinal and edible homologous poly/oligo-saccharides: Structural features, effect on intestinal flora and preventing and treating type 2 diabetes, and their applications: A review

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141031 - 141031

Published: Feb. 1, 2025

Language: Английский

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Advances in the study of Ophiopogon japonicus polysaccharides: structural characterization, bioactivity and gut microbiota modulation regulation

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: May 2, 2025

Ophiopogon japonicus polysaccharides (OJPS), the principal bioactive constituents isolated from japonicus, demonstrate substantial physiological efficacy. OJPS is characterized by a high molecular weight, typically ranging 2.48 to 324.7 kDa. Emerging evidence indicates that modulates composition and structural organization of gut microbiota, thereby maintaining intestinal barrier integrity enhancing both gastrointestinal systemic homeostasis. Moreover, its metabolic derivatives engage in dynamic interactions with microbial communities, mediating cellular signaling cascades endocrine regulation elicit hypoglycemic effects. Despite these findings, comprehensive analyses extraction purification methodologies, elucidation, biological functionalities, mechanistic insights into crosstalk microbiota remain scarce. This review systematically synthesizes contemporary knowledge pertaining preparation, attributes, bioactivity, underpinnings OJPS, particular emphasis on dual regulatory role host physiology ecology.

Language: Английский

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