Ginsenoside Rk3 Treats Corneal Injury Through the HMGB1/TLR4/NF-κB Pathway DOI
Linlin Qu, Yueqin Huang, Yuqing Wu

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(44), P. 24387 - 24399

Published: Oct. 22, 2024

The cornea serves as a vital protective shield for the eye, safeguarding its intricate internal structures from external threats. Damage to compromises this function, triggering inflammation and potentially causing long-term harm. While ginsenoside Rk3 has demonstrated potential repairing corneal barrier reducing inflammation, effectiveness in treating damage remains relatively unexplored. This comprehensive study uses both vivo vitro models investigate therapeutic capabilities of Rk3. Using two damage, benzalkonium chloride-induced mouse model high osmolarity-induced human epithelial cell model, we scrutinized effects treatment. Our results showed that Rk3-treated mice manifested reduced compared with their untreated counterparts. Furthermore, treated exhibited an organized arrangement cells diminished stromal layer thickness, indicating reparative properties Additionally, increased expression tight junction proteins, suppressed inflammatory factors, decreased HMGB1 protein expression, thereby modulating downstream signaling pathways. Collectively, our findings present compelling evidence is promising option injury. By barrier, mitigating specific levels, opens new avenues managing damage.

Language: Английский

Natural bioactive compounds form herbal medicine in Alzheimer’s disease: from the perspective of GSK-3β DOI Creative Commons
Mei Wang, Wendi Huang, Juan Huang

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 7, 2025

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and memory loss. Glycogen synthase kinase 3β (GSK-3β) plays pivotal role in AD pathogenesis, particularly tau protein hyperphosphorylation. Natural bioactive compounds have wide range of sources, medicinally valuable active compound can be extracted from plants, animals, microorganisms. Currently, studies found that various natural plants the potential to improve symptoms, such as resveratrol berberine. Therefore, this review examines modulate GSK-3β activity inhibit hyperphosphorylation tau, offering promising therapeutic strategy for AD. We summarize current understanding alkaloids, phenols, flavonoids, terpenoids other compounds, highlighting their mechanisms action preclinical efficacy.

Language: Английский

Citations

1
Dietary Triterpenoids in Functional Food and Drug Ingredients: a review of structure-activity relationships, biosynthesis, applications, and AI-driven strategies DOI
Chao Fang, Haixia Yang, Daidi Fan

et al.

Trends in Food Science & Technology, Journal Year: 2025, Volume and Issue: unknown, P. 104961 - 104961

Published: March 1, 2025

Language: Английский

Citations

1
Ginsenosides Rg1, Rb1 and rare ginsenosides: promising candidate agents for Parkinson's disease and Alzheimer's disease and network pharmacology analysis DOI Creative Commons

Mingchun Jiang,

Jiaxin Chi,

Yifan Qiao

et al.

Pharmacological Research, Journal Year: 2025, Volume and Issue: 212, P. 107578 - 107578

Published: Jan. 5, 2025

Ginseng has been commonly used as a traditional Chinese medicine in Asian countries for thousands of years. Ginsenosides are the main pharmacologically active ingredients isolated from ginseng and have neuroprotective effects treatment neurodegenerative disorders, such Parkinson's disease (PD) Alzheimer's (AD). To summarise investigate protective roles ginsenosides their underlying mechanisms PD AD, we ''Ginsenoside", ''Parkinson's disease", ''Alzheimer's ''anti-inflammatory", ''antioxidant", ''apoptosis" keywords to search extract relevant literature information scientific databases Elsevier, PubMed, Google Scholar databases. In particular, network pharmacology identify potential targets Rg1 Rb1 AD. By analysing existing research advances results, found that ginsenosides, primarily mediated through anti-inflammation, anti-apoptosis anti-oxidative stress, etc, may be associated with PI3K/Akt, BDNF/TrkB, MAPKs, NF-κB, Nrf2 Wnt/β-catenin signalling pathways. This review systematically summarises different Rg1, Rb1, rare AD provides new strategies disorders. Network paradigm using Rb1.

Language: Английский

Citations

0
Ginsenoside Rg1 in Parkinson’s disease: from basic research to clinical applications DOI Creative Commons

Qianyan Wang,

Wei Lei, Guang‐Hui Chen

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 16, 2025

This review provides an in-depth exploration of the potential Ginsenoside Rg1 in treatment Parkinson's disease (PD). The emphasis this article was therapeutic mechanisms Rg1, which involved reduction inflammation, antioxidant properties, support for neuronal survival and regeneration, regulation cellular energy processes, enhancement autophagic pathways. may protect neurons improve both motor cognitive impairments associated with PD through multiple mechanisms. However, challenges exist clinical application such as low bioavailability well a lack comprehensive long-term safety efficacy data. also reviewed network pharmacology analyses published previously to identify explore molecular targets treatment, while evaluating strategies drug delivery technologies, optimizing administration routes, combination therapies. Ultimately, highlights necessity large-scale trials validate discusses its clinically.

Language: Английский

Citations

0
Ginsenoside RH4 inhibits Ang II-induced myocardial remodeling by interfering with NFIL3 DOI Creative Commons
Yitong Wang,

Xiangbo An,

Feng Wang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 172, P. 116253 - 116253

Published: Feb. 15, 2024

Ventricular remodeling refers to the structural and functional changes of heart under various stimuli or disease influences may also be accompanied by myocardial fibrosis, where an excessive amount fibrous tissue appears in tissue, affecting heart's normal contraction relaxation. Hypertension is posing potential risk causing injury remodeling. The significance renin-angiotensin-aldosterone system (RAAS) cannot overlooked. Drug targeting RAAS can effectively lower blood pressure reduce left ventricular mass. Studies have shown that ginsenoside Rh4 inhibit oxidative stress inflammatory responses. In this study, a model was established using angiotensin (Ang) II, inhibitory effect RH4 on hypertrophy induced Ang II investigated pathological staining quantitative polymerase chain reaction (qPCR). Immunofluorescence qPCR demonstrated causes generation reactive oxygen species (ROS) vitro. target identified transcriptomics. findings indicated could hypertrophy, suggesting cardiovascular protection effects. vitro experiments inhibits hypertrophy. Transcriptomics revealed nuclear factor interleukin-3 (NFIL3) downstream regulator Rh4. By constructing AAV9-NFIL3 injecting it into mice, found NFIL3 overexpression interfered with anti-Ang II-induced These results indicate demonstrates therapeutic effects fibrosis.

Language: Английский

Citations

3
Neuroprotective effects of traditional Chinese medicine Naofucong on diabetic cognitive impairment: Mechanisms involving insulin-degrading enzyme-mediated degradation of Amyloid-β and inhibition of ERK/JNK/p38 MAPK signaling pathway DOI Creative Commons

Yue Tian,

Guangchan Jing,

Ruiying Yin

et al.

Brain Research, Journal Year: 2024, Volume and Issue: unknown, P. 149365 - 149365

Published: Nov. 1, 2024

Language: Английский

Citations

2
Ginsenoside Rk3 Treats Corneal Injury Through the HMGB1/TLR4/NF-κB Pathway DOI
Linlin Qu, Yueqin Huang, Yuqing Wu

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(44), P. 24387 - 24399

Published: Oct. 22, 2024

The cornea serves as a vital protective shield for the eye, safeguarding its intricate internal structures from external threats. Damage to compromises this function, triggering inflammation and potentially causing long-term harm. While ginsenoside Rk3 has demonstrated potential repairing corneal barrier reducing inflammation, effectiveness in treating damage remains relatively unexplored. This comprehensive study uses both vivo vitro models investigate therapeutic capabilities of Rk3. Using two damage, benzalkonium chloride-induced mouse model high osmolarity-induced human epithelial cell model, we scrutinized effects treatment. Our results showed that Rk3-treated mice manifested reduced compared with their untreated counterparts. Furthermore, treated exhibited an organized arrangement cells diminished stromal layer thickness, indicating reparative properties Additionally, increased expression tight junction proteins, suppressed inflammatory factors, decreased HMGB1 protein expression, thereby modulating downstream signaling pathways. Collectively, our findings present compelling evidence is promising option injury. By barrier, mitigating specific levels, opens new avenues managing damage.

Language: Английский

Citations

1