Horticulturae, Journal Year: 2024, Volume and Issue: 10(8), P. 805 - 805
Published: July 30, 2024
Horticultural crops are vulnerable to diverse microbial infections, which have a detrimental impact on their growth, fruit quality, and productivity. Currently, chemical pesticides widely employed manage diseases in horticultural crops, but they negative effects the environment, human health, soil physiochemical properties, biodiversity. Additionally, use of has facilitated development spread resistant pathovars, emerged as serious concern contemporary agriculture. Nonetheless, adverse consequences environment public health worried scientists greatly recent years, led switch biocontrol agents such bacteria, fungi, insects control plant pathogens. Biocontrol (BCAs) form an integral part organic farming, is regarded future sustainable Hence, harnessing potential BCAs important viable strategy disease way that also ecofriendly can improve health. Here, we discuss role biological crops. We different microbial-based fungal, bacterial, viral management. Next, factors affect performance under field conditions. This review highlights genetic engineering enhance efficiency other growth traits. Finally, highlight challenges opportunities biocontrol-based management horticulture research directions boost efficacy applications.
Language: Английский
Citations
8Unveiling the anticancer potential of the ethanolic extract from Trichoderma asperelloides
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: May 1, 2024
The discovery of new therapeutic alternatives for cancer treatment is essential improving efficacy and specificity, overcoming resistance, enabling a more personalized approach each patient. We investigated the antitumor activity crude ethanolic extract fungus Trichoderma asperelloides (ExtTa) its interaction with chemotherapeutic drugs. It was observed, by MTT cytotoxicity assay, that ExtTa significantly reduced cell viability in breast adenocarcinoma, glioblastoma, lung carcinoma, melanoma, colorectal sarcomas lines. highest selectivity were found against glioblastoma T98G HCT116 approximately four times cytotoxic to those tumor cells than non-cancer A synergistic effect between doxorubicin osteosarcoma Saos-2 cells, as well 5-fluorouracil carcinoma using CompuSyn software. Our data unravel presence bioactive compounds effects present T. extract, potential developing novel anticancer agents.
Language: Английский
Citations
4A New Highly Oxidized 5/5/6 Tricyclic Sesquiterpene Skeleton from the Marine-Derived Fungus Metarhizium Sp. P2100
Published: Jan. 1, 2025
Language: Английский
Citations
0New Polyketides From Trichoderma harzianum and Their Antifungal Activity
Chemistry & Biodiversity, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 6, 2025
ABSTRACT Chemical investigation of the marine‐derived fungus Trichoderma harzianum ZN‐4 led to isolation and identification seven new secondary metabolites, harzianolides K–Q ( 1 – 7 ). The complete structures compounds were determined by high‐resolution mass spectrometry nuclear magnetic resonance spectroscopic analyses coupled with electronic circular dichroism calculations. isolates inactive as antibacterial antitumor agents. However, K ), L 2 M 3 ) O 5 exhibited weak moderate anti‐ Pestalotiopsis theae activity minimum inhibitory concentration values at range 25–100 µg/mL.
Language: Английский
Citations
0Editorial: Unveiling the hidden arsenal: exploring secondary metabolites and fungal development in pathogenic fungi
Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15
Published: March 7, 2025
Pathogenic fungi pose a significant threat to global health and agriculture, contributing wide range of infections in both humans plants. These organisms produce an array secondary metabolites, which, while not essential for primary growth, play crucial roles their adaptability, virulence, interactions with host environments (Yang et al., 2022, Guo 2023). The exploration these metabolites has uncovered diverse bioactivities, ranging from antimicrobial immunosuppressive properties involvement fungal morphogenesis toxin production(Lara da Costa 2022). Understanding the biosynthesis, regulation, functional pathogenic is developing novel antifungal strategies mitigating diseases. This Research Topic compiles cutting-edge studies that delve into complex interplay between metabolite development, pathogenicity. articles offer comprehensive examination molecular mechanisms governing production, influence on immune responses. Additionally, several contributions explore innovative methodologies characterizing evaluating potential as targets therapies.In this Topic, we highlight four pivotal addressing critical aspects field: Jin led by Prof. Jing Si Institute Microbiology, Beijing Forestry University, renowned advancing genome annotation natural product discovery, presented high-quality assembly Sanghuangporus weigelae. medicinal fungus traditionally used East Asian pharmacopeia its anti-inflammatory properties. By integrating multi-omics approaches, study identified key metabolic pathways involved biosynthesis bioactive compounds, such terpenoids polysaccharides, offering valuable insights applications metabolites.Zhao Quality Standard Monitoring Technology Agro-product (Guangdong Academy Agricultural Sciences), specializing mycotoxin risk assessment food systems, revealed regulatory aflatoxin Aspergillus flavus. Their work demonstrated acetohydroxy acid synthase (AHAS) dihydroxy dehydratase, enzymes branched-chain amino metabolism, directly modulated findings provide actionable disrupting toxigenic agricultural storage.University, whose research focuses clinical mycology resistance epidemiology, featured susceptibility Candida species isolated pregnant women Yemen, shedding light increasing prevalence urgent need effective treatments resource-limited settings. underscores growing concern highlights necessity tailored therapeutic approaches. Satterlee United States Department Agriculture Toxicology Mycotoxin Unit, pioneers chemical ecology, examined A. flavus Fusarium verticillioides, two major maize pathogens. reveal competitive dynamics mediated mycotoxins fumonisin, new perspectives ecological controlling contamination crops.Collectively, illuminate dual nature metabolites-as drivers pathogenicity reservoirs potential. They underscore importance genomic, ecological, combat threats. As escalates climate change alters biogeography, interdisciplinary approaches will be safeguarding security.We hope catalyze innovation discovery inspire collaborative efforts unravel hidden complexities biology.
Language: Английский
Citations
0A new sesquiterpene with a specialized [4,4] bicyclononane skeleton from the marine-derived fungus Metarhizium sp. P2100
Tetrahedron, Journal Year: 2025, Volume and Issue: unknown, P. 134607 - 134607
Published: March 1, 2025
Language: Английский
Citations
0The Polyketides with Antimicrobial Activities from a Mangrove Endophytic Fungus Trichoderma lentiforme ML-P8-2
Marine Drugs, Journal Year: 2023, Volume and Issue: 21(11), P. 566 - 566
Published: Oct. 28, 2023
Five new polyketides, including two chromones (1-2), phenyl derivatives (4-5), and a tandyukusin derivative (6), along with five known polyketides (3 7-10) were isolated from mangrove endophytic fungus Trichoderma lentiforme ML-P8-2. The planar structures of compounds elucidated via detailed 1D, 2D NMR, HR-ESI-MS analysis. ECD spectra, optical rotation values calculation, alkali hydrolysis applied in the determination absolute configuration compounds. In bioassays, 6 9 exhibited promising antifungal activities against Penicillium italicum, an MIC value 6.25 μM for both Moreover, 3 displayed moderate AChE inhibitory activity IC50 20.6 ± 0.3 μM.
Language: Английский
Citations
10Field biocontrol efficacy of Trichoderma spp. in fresh and dry formulations against rice blast and brown spot diseases and yield effect
European Journal of Plant Pathology, Journal Year: 2024, Volume and Issue: 170(1), P. 1 - 13
Published: April 10, 2024
Language: Английский
Citations
3Cytochrome P450 CYP736A12 is crucial for Trichoderma asperellum-induced alleviation of phoxim phytotoxicity and reduction of pesticide residue in tomato roots
Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 471, P. 134299 - 134299
Published: April 12, 2024
Language: Английский
Citations
3Discovery of Enzyme Inhibitors from Mangrove Sediment Derived Fungus Trichoderma harzianum SCSIO 41051
Chemistry & Biodiversity, Journal Year: 2024, Volume and Issue: 21(4)
Published: Feb. 15, 2024
One new fatty acid derivative, (2E,4E)-6,7-dihydroxy-2-methylocta-2,4-dienoic (1), and 16 known compounds (2-17) were isolated from the mangrove sediment derived fungus Trichoderma harzianum SCSIO 41051. Their structures established by spectroscopic methods, computational ECD, Mo
Language: Английский
Citations
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