Shrimp peptide QMDDQ improves scopolamine-induced memory impairments by activating the Notch1 signaling pathway

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106041 - 106041

Published: Feb. 1, 2025

Language: Английский

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Sex differences in reward-based operant conditioning performance and neurotransmitter changes following chronic sleep restriction stress in rats

Behavioral and Brain Functions, Journal Year: 2025, Volume and Issue: 21(1)

Published: Feb. 28, 2025

Sleep deprivation significantly impairs cognitive function, which disrupts daily life. However, sex differences in these impairments are not well understood, as most preclinical studies primarily use male animals, neglecting potential between sexes. This study aims to investigate sex-specific function under sleep using reward-based operant conditioning tasks. Sprague-Dawley rats were pre-trained on a lever-press task and subsequently divided into control chronic restriction (CSR) groups. The CSR group underwent 14 days of restriction. After modeling, assessed the open field test, retraining lever-pressing task, signal discrimination extinction evaluate motor abilities, memory formation, learning, flexibility. impaired performance both sexes, with requiring more time exhibiting lower accuracy. In showed longer feeding latency accuracy compared females. also specifically increased frequency responses rats. enhanced exploration females higher frequencies than males. Biochemically, induced alterations, including elevated serum MDA MAO levels males serotonin, dopamine, epinephrine Although activation was observed metabolites tryptophan-kynurenine pathway, evident kynurenic acid metabolism prefrontal cortex. female rats, significant observed. Male exhibited discrimination, while learning These accompanied by CSR-induced oxidative stress, neurotransmitter dysregulation, disturbances tryptophan metabolic pathway. findings underscore importance considering understanding effects developing targeted intervention strategies.

Language: Английский

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Ginseng in Delaying Brain Aging: Progress and perspectives

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156587 - 156587

Published: March 1, 2025

Language: Английский

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Foods for Sleep Improvement: A Review of the Potential and Mechanisms Involved

Foods, Journal Year: 2025, Volume and Issue: 14(7), P. 1080 - 1080

Published: March 21, 2025

Insomnia affects one-third of the world’s population; negative effects insomnia are significant, and traditional medications have numerous side cause considerable suffering. This has aroused interest in obtaining sleep-improving substances from foods. study conducted a comprehensive literature review using Web Science PubMed with keywords like “sleep”, “insomnia”, “food”. A subsequent summary revealed that certain foods, including milk, Ziziphus jujuba, Lactuca sativa, ginseng, Schisandra chinensis, Juglans regia, etc., purported to enhance sleep quality by prolonging duration, reducing latency, alleviating anxiety. The mechanisms these foods’ mainly occur via central nervous system, particularly gamma-aminobutyric acid (GABA)ergic 5-hydroxytryptamine (5-HT)ergic systems. Although this supports fact they potential, further research is needed. There also issues such as more limited fewer mechanisms, pharmacokinetic studies, models being involved. These need be addressed future adequately address problem insomnia. It hoped will contribute into foods properties and, future, provide an effective natural alternative for those seeking medication.

Language: Английский

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Ckip-1 3’UTR alleviates prolonged sleep deprivation induced cardiac dysfunction by activating CaMKK2/AMPK/cTNI pathway

Molecular Biomedicine, Journal Year: 2024, Volume and Issue: 5(1)

Published: June 14, 2024

Abstract Sleep deprivation (SD) has emerged as a critical concern impacting human health, leading to significant damage the cardiovascular system. However, underlying mechanisms are still unclear, and development of targeted drugs is lagging. Here, we used mice explore effects prolonged SD on cardiac structure function. Echocardiography analysis revealed that function was significantly decreased in after five weeks SD. Real-time quantitative PCR (RT-q-PCR) Masson staining showed remodeling marker gene Anp (atrial natriuretic peptide) fibrosis were increased, Elisa assay serum levels creatine kinase (CK), kinase-MB (CK-MB), ANP, brain peptide (BNP) troponin T (cTn-T) increased SD, suggesting injury occurred. Transcript sequencing indicated genes involved regulation calcium signaling pathway, dilated cardiomyopathy, muscle contraction changed Accordingly, Western blotting demonstrated cardiac-contraction associated CaMKK2/AMPK/cTNI pathway inhibited. Since our preliminary research confirmed vital role Casein Kinase-2 -Interacting Protein-1 (CKIP-1, also known PLEKHO1) regulation. found 3’ untranslated region Ckip-1 (Ckip-1 3’UTR) decreased, while coding sequence CDS) remained unchanged Significantly, adenovirus-mediated overexpression 3’UTR alleviated SD-induced dysfunction by activating which proposed therapeutic potential treating heart disease.

Language: Английский

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Targeting sirtuins in neurological disorders: A comprehensive review

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 292, P. 139258 - 139258

Published: Dec. 28, 2024

Language: Английский

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WuYou Decoction effectively reduces neuronal damage, synaptic dysfunction, and Aβ production in rats exposed to chronic sleep deprivation by modulating the Aβ-related enzymes and SIRT1/Nrf2/NF-κB pathway

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 118939 - 118939

Published: Oct. 1, 2024

Language: Английский

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S100A8 knockdown activates the PI3K/AKT signaling pathway to inhibit microglial autophagy and improve cognitive impairment mediated by chronic sleep deprivation

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 143, P. 113375 - 113375

Published: Oct. 16, 2024

Cognitive dysfunction is one of the major symptoms chronic sleep deprivation (CSD). Abnormal autophagy and apoptosis are thought to be important mechanisms. S100 Calcium Binding Protein A8 (S100A8) plays a key role in microglia. This study investigated whether S100A8 knockdown can effectively inhibit aberrant microglia improve cognitive function by activating phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway under CSD conditions.

Language: Английский

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Exploring β-caryophyllene: a non-psychotropic cannabinoid's potential in mitigating cognitive impairment induced by sleep deprivation

Archives of Pharmacal Research, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 9, 2024

Language: Английский

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