From Spear to Shield: A Novel Antifungal Drug that Safely Enhances Rice Immune Defenses DOI

Bin Bin Huang,

Ming Wei Gao,

Xi Wang

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

The infection and resistance of pathogenic fungi pose a significant threat to food crop safety, highlighting the urgent need for new green antifungal agents. Fusarium acid (FA) with its simple novel structure correlates principles pesticides has demonstrated substantial broad-spectrum activity. In previous study, several promising lead compounds were identified. This study focused on further optimizing compound A1. Its inhibitory effect was evaluated against six different Notably, anti-Magnaporthe oryzae (M. oryzae) activity B4 significantly enhanced an EC50 value 910 ng/mL. Rice safety tests indicated that not only exhibited no adverse rice growth chlorophyll synthesis but also induced plant immunity by increasing levels polyphenol oxidase (PPO), peroxidase (POD), superoxide dismutase (SOD), soluble sugars. Further investigations into mechanism it permeability damage mycelial membrane, thereby leading electrolyte leakage loss essential cellular substances. Subsequently, production reactive oxygen species (ROS) in M. cell, including •OH, •O2–, 1O2, while promoting increased malondialdehyde (MDA) SOD enzyme effectively inhibited conidia melanin production. These findings FA derivatives hold potential as strategy disease management offer valuable insights control fungal diseases.

Language: Английский

Fusaricate L, a new fusaric acid derivative from mangrove rhizosphere soil-derived Streptomyces angustmyceticus J-71 DOI
Jiajia Lu,

Ruibin Kuang,

Jing-Jing Ye

et al.

Natural Product Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 5

Published: March 7, 2025

An undescribed fusaric acid derivative, fusaricate L (1) was isolated together with eight known compounds (2-9) from mangrove plant Rhizophora apiculata rhizosphere soil-derived Streptomyces angustmyceticus J-71. The structures of these were established by extensive NMR spectroscopic data and comparison the literature. Moreover, all metabolites tested for antifungal antibacterial activities against a panel human pathogens. Compounds 4, 6, 7 9 showed modest antimicrobial towards methicillin- susceptible Staphylococcus aureus.

Language: Английский

Citations

0
From Spear to Shield: A Novel Antifungal Drug that Safely Enhances Rice Immune Defenses DOI

Bin Bin Huang,

Ming Wei Gao,

Xi Wang

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

The infection and resistance of pathogenic fungi pose a significant threat to food crop safety, highlighting the urgent need for new green antifungal agents. Fusarium acid (FA) with its simple novel structure correlates principles pesticides has demonstrated substantial broad-spectrum activity. In previous study, several promising lead compounds were identified. This study focused on further optimizing compound A1. Its inhibitory effect was evaluated against six different Notably, anti-Magnaporthe oryzae (M. oryzae) activity B4 significantly enhanced an EC50 value 910 ng/mL. Rice safety tests indicated that not only exhibited no adverse rice growth chlorophyll synthesis but also induced plant immunity by increasing levels polyphenol oxidase (PPO), peroxidase (POD), superoxide dismutase (SOD), soluble sugars. Further investigations into mechanism it permeability damage mycelial membrane, thereby leading electrolyte leakage loss essential cellular substances. Subsequently, production reactive oxygen species (ROS) in M. cell, including •OH, •O2–, 1O2, while promoting increased malondialdehyde (MDA) SOD enzyme effectively inhibited conidia melanin production. These findings FA derivatives hold potential as strategy disease management offer valuable insights control fungal diseases.

Language: Английский

Citations

0