Glycyrrhiza uralensis Polysaccharide Modulates Characteristic Bacteria and Metabolites, Improving the Immune Function of Healthy Mice

Nutrients, Journal Year: 2025, Volume and Issue: 17(2), P. 225 - 225

Published: Jan. 9, 2025

Polysaccharides from Glycyrrhiza are known to have several bioactive effects. Previous studies found that low-molecular-weight polysaccharide (GP1) is degraded by Muribaculum_sp_H5 and promotes the production of beneficial bacteria metabolites, which improves immune disorder intestinal injury, then enhances body's regulation ability. However, effect GP1 on a healthy body has not been studied. In this study, we aimed reveal enhancement mechanism mice. The cytotoxicity immunomodulatory activity were analyzed cell experiment; effects antioxidation, gut microbiota structure studied in vivo. addition, enhancing response was multi-omics. results show enhanced function mice increasing index organs, improving organizational secretion cytokines immunoglobulin. also increased contents antioxidant factors such as total capacity (T-AOC), glutathione peroxidase (GSH-Px) superoxide dismutase (SOD) various organs reduced content oxide malondialdehyde (MDA), thus capacity, promoting proliferation prolonging life. Moreover, promoted bacteria, including Muribaculaceae_unclassified, Muribaculum, Prevotellaceae_UCG-001, Paramuribaculum, characteristic metabolites (collectively referred postbiotics), α-tocopherol, arachidonic acid, melibiose, taurine, nicotinic acid. These postbiotics proven health maintaining functions. postbiotics, should be its effect. It expected promising dietary supplement.

Language: Английский

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Immune Restoration Mechanism Analysis of Akkermansia PROBIO in Mice Treated with Cyclophosphamide through Re-balancing Microbiota Composition

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106450 - 106450

Published: March 1, 2025

Language: Английский

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Comparative Effects of Turmeric Secondary Metabolites Across Resorptive Bone Diseases

Metabolites, Journal Year: 2025, Volume and Issue: 15(4), P. 266 - 266

Published: April 11, 2025

Background: Turmeric (Curcuma longa L.) rhizomes, whose secondary metabolites include polyphenols and terpenoids, have been used medicinally for millennia. However, modern scientific inquiry has primarily focused on medicinal effects of turmeric's polyphenolic curcuminoids, including when evaluating turmeric use to maintain bone health. Methods: Disease-specific biological major (polyphenols and/or terpenoids), with or without associated rhizome-derived polysaccharides, were determined in vivo using pre-clinical models clinically relevant resorptive diseases induced by different mechanisms. These included inflammatory arthritis, cancer-driven osteolytic metastases, hormone deficiency-driven post-menopausal osteoporosis. Results: In the arthritis model, safety profile curcuminoids alone was superior. terpenoids each had anti-inflammatory prevented resorption, polysaccharide-containing curcuminoid extracts having greater effect than alone. human breast cancer metastases containing polysaccharides tended yield reducing osteolysis tumor progression more complex extracts. contrast, only purified loss a osteoporosis while effect. vitro metabolite disease-specific mechanistic pathways synoviocytes, osteoclasts, cells consistent documented outcomes differential metabolite-specific effects. Conclusions: summary, these findings suggest that potential musculoskeletal are complex, pathway- target-specific, not limited concerns potentially limiting certain uses.

Language: Английский

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An inulin-type fructan from Codonopsis pilosula ameliorates cyclophosphamide-induced immunosuppression and intestinal barrier injury in mice

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 310, P. 143312 - 143312

Published: April 17, 2025

Language: Английский

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Research Progress of Turmeric and Its Active Components in the Treatment of Colorectal Cancer

Traditional Chinese Medicine, Journal Year: 2025, Volume and Issue: 14(04), P. 1823 - 1830

Published: Jan. 1, 2025

Language: Английский

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Immunomodulatory mechanisms of low molecular weight peptides from Pinctada martensii: A network pharmacology and in vivo study on gut microbiota and immune function

Journal of Functional Foods, Journal Year: 2025, Volume and Issue: 129, P. 106874 - 106874

Published: May 6, 2025

Language: Английский

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Zearalenone removal using inactivated yeast embedded in porous modified yam starch aerogels and its application in corn silk tea

Food Chemistry, Journal Year: 2024, Volume and Issue: 460, P. 140593 - 140593

Published: July 23, 2024

Language: Английский

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Structural characterization and immunomodulatory activity of polysaccharides from the lateral roots of Aconitum carmichaelii

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 136935 - 136935

Published: Oct. 30, 2024

Language: Английский

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Yam protein ameliorates cyclophosphamide-induced intestinal immunosuppression by regulating gut microbiota and its metabolites

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 279, P. 135415 - 135415

Published: Sept. 7, 2024

Language: Английский

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Glycoprotein from selenium-enriched yam activates immune cells and enhances intestinal immunity via the NF-κB signaling pathway

Food Bioscience, Journal Year: 2024, Volume and Issue: 61, P. 104671 - 104671

Published: July 2, 2024

Language: Английский

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