International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 283, P. 137427 - 137427
Published: Nov. 12, 2024
Language: Английский
Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(24), P. 13593 - 13609
Published: June 5, 2024
Inflammatory bowel disease (IBD) is a recurrent inflammatory condition affecting the gastrointestinal tract, and its clinical treatment remains suboptimal. Probiotics have shown effectiveness in alleviating dextran sulfate sodium salt (DSS)-induced colitis, exhibiting strain-specific anti-inflammatory properties. In this study, we compared therapeutic effects of five strains Bifidobacterium bifidum isolated from healthy adult feces on DSS-induced colitis mice. Additionally, investigated underlying mechanisms by examining gut microbiota composition microbial metabolome. Our findings highlighted superior efficacy B. M1-3 to other strains. It significantly improved symptoms, mitigated barrier disruption, reduced colonic inflammation DSS-treated Moreover, analysis revealed that increased abundance diversity microbiota. Specifically, it Muribaculaceae, Lactobacillus, Bacteroides, Enterorhabdus, while decreasing Escherichia-Shigella. Furthermore, our nontargeted metabolomics illustrated had regulatory effect various metabolic pathways, including tyrosine metabolism, lysine degradation, tryptophan metabolism. Importantly, confirmed efficiency was dependent These results are conducive development probiotic products for colitis.
Language: Английский
Citations
5
Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 281, P. 116662 - 116662
Published: June 28, 2024
Language: Английский
Citations
5
Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 12, 2025
This study investigated whether the galactooligosaccharide (GOS)-metabolism-related genes (GOS-cluster) in
Language: Английский
Citations
0
mSystems, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 27, 2025
ABSTRACT Colon cancer (CC) is one of the most common cancers globally, which associated with gut microbiota intimately. In current research, exploring complex interaction between microbiomes and CC a hotspot. However, information on in previous studies based fecal, does not fully display microbial environment CC. Herein, we collected mucosal tissue samples from both tumor normal regions 19 patients clarified composition by 16S rRNA metagenomic sequencing. Additionally, RNA-Seq was also conducted to identify different expression genes samples. We revealed significantly community structures profiles Depending correlation analysis, demonstrated that 1,472 were correlated microbiota. Our study reveals significant enrichment Campylobacter jejuni mucosa CC, correlates bile secretion. observe negative C. immune cells CD4+ Tem mast cells. Finally, discovered metabolic bacterial endosymbiont Bathymodiolus sp., Bacillus wiedmannii , Mycobacterium tuberculosis had survival value for ignored research. Overall, our expands understanding interplay provides new targets treatment IMPORTANCE This contributes colon (CC). By examining rather than solely relying fecal samples, have uncovered previously unknown aspects CC-associated findings reveal distinct gene progression. Notably, mucosa, linked secretion, underscores potential mechanisms pathogenesis. observed correlations taxa cell populations offer avenues immunotherapy research Importantly, this introduces implications expanding therapeutic beyond conventional strategies. elucidating these correlations, only uncovering role but establishes foundation mechanistic cancer, emphasizing broader impact biology.
Language: Английский
Citations
0
Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
The interaction between lactic acid bacteria (LAB) and curcumin can influence bioactivity; however, the strain-specific metabolic transformations of by LAB remain unclear. In our study, two exhibiting distinct activities on were selected: Lactobacillus gasseri ATCC 33323 (LM) could metabolize curcumin, while Limosilactobacillus reuteri 23272 (LUM) not. Liquid chromatography-mass spectrometry (LC-MS) analysis showed that LUM preserved curcumin's native form, whereas LM metabolized it completely. Time-course studies indicated via hydrogenation demethylation, producing over 70% tetrahydrocurcumin. Additionally, fermentation exhibited superior anti-inflammatory effects than in LPS-induced RAW264.7 macrophages. Conversely, broth demonstrated higher antioxidant activity LUM. These findings indicate different strains interact with ways significantly alter its bioactivities. This research enhances understanding biological under strains.
Language: Английский
Citations
0
Microorganisms, Journal Year: 2025, Volume and Issue: 13(5), P. 1084 - 1084
Published: May 7, 2025
The importance of the microbiome, particularly gut microbiota and its implications for health, is well established. However, an increasing number studies further strengthen link between imbalanced a greater predisposition to different diseases. constitutes fundamental ecosystem maintaining human health. Its alteration, known as dysbiosis, associated with wide range conditions, including intestinal, metabolic, immunological, or neurological pathologies, among others. In recent years, there has been substantial increase in knowledge about probiotics—bacterial species that enhance health address various diseases—with numerous reporting their benefits preventing improving these conditions. This review aims analyze most common pathologies resulting from imbalance microbiota, detail important probiotics, functions, mechanisms action relation
Language: Английский
Citations
0
Probiotics and Antimicrobial Proteins, Journal Year: 2024, Volume and Issue: 16(6), P. 2085 - 2101
Published: June 19, 2024
Language: Английский
Citations
3
Biomedicines, Journal Year: 2024, Volume and Issue: 12(12), P. 2910 - 2910
Published: Dec. 20, 2024
Inflammatory bowel disease (IBD) is a chronic condition that affects about 7 million people worldwide, and new therapies are needed. Understanding the complex roles bile acids (BAs) play in IBD may lead to development of novel treatments independent direct immunosuppression. This review discusses latest discoveries BAs pathogenesis explores how these offer promising therapeutic targets treat improve patient outcomes. Several discussed include specific BA receptor (BAR) agonists, dietary therapies, supplements, probiotics, mesenchymal stem cell have all been shown decrease activity.
Language: Английский
Citations
1
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 283, P. 137427 - 137427
Published: Nov. 12, 2024
Language: Английский
Citations
1