Oleanolic Acid Alleviates Hyperuricemia via Gut Microbiota Control the Integrity of Gut Barrier and the Expressions of Urate Transporter in Mice

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Hyperuricemia (HUA) is a globally prevalent metabolic disorder characterized by an imbalance in uric acid (UA) production and excretion. In this study, we found that oleanolic (OA), natural pentacyclic triterpene, effectively reduced HUA associated kidney injury C57BL/6J mice. A 12-week OA treatment significantly dose-dependently UA creatinine levels serum urine while suppressing hepatic xanthine oxidase activity Mechanistic analysis revealed modulates the expression of urate transporters including ABCG2, GLUT9, URAT1 small intestine. Furthermore, restored gut microbiota imbalances, increased short-chain fatty production, enhanced expressions intestinal tight junction proteins mice, thereby improving barrier integrity Consequently, fecal transplantation (FMT) was employed to illustrate major mediating role OA's alleviation Recipient mice transplanted with feces from OA-treated exhibited lower blood urinary levels, inflammation, improved balance compared those receiving untreated (p < 0.05). Additionally, FMT normalized transporter reinforced junctions recipient These findings underscore mitigates primarily modulating microbiota, regulating expression, reinforcing integrity, offering novel insights into its preventive potential for managing related complications.

Language: Английский

Hydroxytyrosol as a Mitochondrial Homeostasis Regulator: Implications in Metabolic Syndrome and Related Diseases

Antioxidants, Journal Year: 2025, Volume and Issue: 14(4), P. 398 - 398

Published: March 27, 2025

Hydroxytyrosol (HT), a principal bioactive phytochemical abundant in Mediterranean dietary sources, has emerged as molecule of significant scientific interest owing to its multifaceted health-promoting properties. Accumulating evidence suggests that HT’s therapeutic potential metabolic disorders extends beyond conventional antioxidant capacity encompass mitochondrial regulatory networks. This review synthesizes contemporary from our systematic investigations and the existing literature delineate comprehensive modulatory effects on homeostasis. We systematically summarized impact HT dynamics (fusion/fission equilibrium), biogenesis energy metabolism, mitophagy, inter-organellar communication with endoplasmic reticulum, microbiota–mitochondria crosstalk. Through this multidimensional analysis, we established homeostasis modulator applications syndrome (MetS) related pathologies including type 2 diabetes mellitus, obesity-related dysfunction, dyslipidemia, non-alcoholic steatohepatitis, hypertension-related complications. Moreover, further discussed translational challenges research, emphasizing imperative for direct target identification, mitochondrial-targeted delivery system development, combinatorial strategies. Collectively, provides mechanistic framework advancing research accelerating clinical implementation MetS diseases.

Language: Английский

Anti-Inflammatory and Neuroprotective Polyphenols Derived from the European Olive Tree, Olea europaea L., in Long COVID and Other Conditions Involving Cognitive Impairment

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(20), P. 11040 - 11040

Published: Oct. 14, 2024

The European olive tree, Olea europaea L., and its polyphenols hold great therapeutic potential to treat neuroinflammation cognitive impairment. This review examines the evidence for anti-inflammatory neuroprotective actions of their in treatment long COVID neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s (PD), multiple sclerosis (MS). Key findings suggest that exhibit antioxidant, anti-inflammatory, neuroprotective, antiviral properties, making them promising candidates intervention, especially when formulated unique combinations. Recommendations future research directions include elucidating molecular pathways through mechanistic studies, exploring implications polyphenol supplementation, conducting clinical trials assess efficacy safety. Investigating synergistic effects with other agents addressing different targets is suggested further exploration. reviewed strengthens translational value conditions involving dysfunction emphasizes novelty new formulations.

Language: Английский