Structural Characterization of Water-Soluble Pectin from the Fruit of Diospyros lotus L. and Its Protective Effects against DSS-Induced Colitis in Mice

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Polysaccharides from Diospyros lotus L. were investigated for their structural characterization and anti-inflammatory activity. Four low polymer dispersity index (PDI) subfractions obtained: DRP-1 (153.95 kDa), DRP-2 (61.22 DRP-3 (22.80 DRP-4 (8.93 respectively. contained the highest number of RG-I domains (43.25%), while had degree methyl esterification (37.5%). Results dextran sulfate sodium (DSS) salt-induced ulcerative colitis (UC) mice model indicated that DCP promoted mucosal tight junction protein (caudin-1 occludin) expression. Moreover, improved microbial community composition through selective enrichment beneficial bacteria such as Lachnospiraceae Lactobacillaceae. The activity was speculated to be related its neutral sugar side chain degree. These results suggested could prevent DSS-induced inhibit colon inflammation by maintaining a balanced gut microbiome protecting barrier.

Language: Английский

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Induction of multicomponent peptide assembly via solvent exchange strategy for enhanced structure and bioactivities

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 500, P. 157484 - 157484

Published: Nov. 1, 2024

Language: Английский

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Candida utilis Ameliorates Dextran Sulfate Sodium-Induced Colitis in Mice via NF-κB/MAPK Suppression and Gut Microbiota Modulation

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 1993 - 1993

Published: Feb. 25, 2025

Candida utilis (CUM) possesses various biological effects, including anti-inflammatory, intestinal microbiota regulatory, and immunomodulatory activities. However, there has been little exploration regarding the effects of CUM on ulcerative colitis (UC). Therefore, this study aimed to investigate beneficial alleviating dextran sulfate sodium (DSS)-induced UC in mice explore potential underlying mechanisms. Here, effect was analyzed using a DSS-induced mouse model (n = 9), results which indicated decrease disease activity index (DAI) mice. Furthermore, alleviated colon shortening, minimized tissue damage, preserved tight junction proteins (Claudin-3, Occludin, ZO-1). reduced level pro-inflammatory cytokines (IL-1β, IL-6, TNF-α), inhibited activation NF-ĸB, MAPK PPARγ signaling pathways, decreased oxidative mediators (MPO, SOD MDA) Additionally, it mitigated dysbiosis by increasing abundance Prevotellaceae Lactobacillus while decreasing Bacteroidaceae Enterobacteriaceae. short-chain fatty acids (SCFAs) content The above provide scientific basis for CUM, as natural supplement, restore balance gut inflammatory promote health.

Language: Английский

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Harnessing diatoms for sustainable economy: Integrating metabolic mechanism with wastewater treatment, biomass production and applications

Algal Research, Journal Year: 2025, Volume and Issue: unknown, P. 104031 - 104031

Published: April 1, 2025

Language: Английский

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Marine algae oils from Phaeodactylum tricornutum and Laminaria japonica alleviate obesity, insulin resistance, and gut microbiota dysbiosis in high-fat diet-fed mice

Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 117, P. 106234 - 106234

Published: May 10, 2024

The present study was aimed to investigate the effects of Phaeodactylum tricornutum oil (PO) and Laminaria japonica (LO) against obesity other metabolic disorders in a high-fat diet (HFD) induced obese mouse model. results revealed that PO or LO supplementation significantly reduced HFD-induced body weight gain, hyperlipemia, fat accumulation mice. also inhibited SREBP-1-mediated de novo lipogenesis PPARγ-mediated adipogenesis, as well enhanced PPARα-mediated fatty acid β-oxidation WAT liver HFD-fed Moreover, attenuated low-grade chronic inflammation, hyperglycemia insulin resistance Furthermore, Dietary modulated gut microbiota dysbiosis increased SCFAs production. More importantly, our manifested ameliorative effect obesity, IR comparable, but superior than krill fish oil.

Language: Английский

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Causal relationship between gut microbiota and thyroid nodules: a bidirectional two-sample Mendelian randomization study

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 8, 2024

Objective Emerging evidence suggests alterations in gut microbiota (GM) composition following thyroid nodules (TNs) development, yet the causal relationship remains unclear. Utilizing Mendelian Randomization (MR), this study aims to elucidate dynamics between GM and TNs. Methods Employing summary statistics from MiBioGen consortium ( n =18,340) FinnGen (1,634 TNs cases, 263,704 controls), we conducted univariable multivariable MR analyses explore GM-TNs association. Techniques including inverse variance weighted, MR-Egger regression, weighted median, MR-PRESSO were utilized for inference. Instrumental variable heterogeneity was assessed through Cochran’s Q statistic leave-one-out analysis. Reverse applied taxa showing significant forward associations, with multivariate adjustments confounders. Results Our findings suggest that certain microbiota, identified as Ruminococcaceae_NK4A214_group (OR, 1.89; 95%CI, 0.47-7.64; p = 0.040), Senegalimassilia 1.72; 1.03-2.87; =0.037), Lachnospiraceae (OR,0.64; 95%CI,0.41-0.99; =0.045), exhibit a protective influence against TNs’ indicated by negative associations. In contrast, categorized Desulfovibrionales 0.63; 0.41-0.95; =0.028), Prevotella_7 0.79; 0.63-1.00; =0.049), Faecalibacterium 0.66; 0.44-1.00; =0.050), Desulfovibrionaceae 0.55; 0.35-0.86; =0.008), Deltaproteobacteria 0.65; 0.43-0.97; =0.036) are have positive correlation TNs, suggesting they may serve risk factors. did not establish links. After comprehensive adjustment confounders, (Order), (Family), (Class) remain implicated potential contributors risk. Discussion This substantiates link underscoring thyroid-gut axis’s relevance. The advocate integration of profiles prevention management, offering foundation future research domain.

Language: Английский

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Protective effects of insoluble dietary fiber from cereal bran against DSS-induced chronic colitis in mice: From inflammatory responses, oxidative stress, intestinal barrier, and gut microbiota

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 283, P. 137846 - 137846

Published: Nov. 18, 2024

Language: Английский

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Rice bran ameliorated DSS-induced colitis by suppressing inflammation and modulating gut microbiota

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 25, 2024

Globally, the incidence of colitis is on rise. Rice bran (RB) a promising natural dietary supplement. The research aimed to explore how RB impacts in mice caused by dextran sulfate sodium. Notably, administering led better weight control, colon lengths, and decreased disease activity index. Furthermore, it was discovered that boosts antioxidant abilities, elevates short-chain fatty acids concentrations, fortifies intestinal mucosal barrier, lowers histopathology scores, suppresses inflammation. Ileibacterium vane's relative abundance greater mice. Administering reduction comparative vans exhibited an increased Akkermansia muciniphila. These findings provide scientific basis for development as supplement improve gut microbiota dysbiosis enhance comprehensive utilization value RB.

Language: Английский

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The senotherapeutic potential of phytochemicals for age-related intestinal disease

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 104, P. 102619 - 102619

Published: Dec. 3, 2024

During the last few decades, life expectancy has increased worldwide along with prevalence of several age-related diseases. Among aging pathways, cellular senescence and chronic inflammation (or "inflammaging") appear to be connected gut homeostasis dysbiosis microbiome. Cellular is a state essentially irreversible cell cycle arrest that occurs in response stress. Although senescent cells (SC) remain metabolically active, they do not proliferate can secrete inflammatory other factors comprising senescence-associated secretory phenotype (SASP). Accumulation SCs been linked onset diseases, brain, bones, gastrointestinal tract, organs tissues. The microbiome undergoes substantial changes tightly interconnected either successful (healthy) or disease. Senotherapeutic drugs are compounds clear modulate release SASP hence attenuate impact pro-inflammatory state. Phytochemicals, phenolic terpenes, which have antioxidant anti-inflammatory activities, could also senotherapeutic given their ability act upon senescence-linked pathways. aim this review dissect links among microbiome, senescence, inflammaging, disease, as well explore phytochemicals potential senotherapeutics, focusing on interactions microbiota. Coordinated targeting these inter-related processes might unveil new strategies for promoting healthy aging.

Language: Английский

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Xin-Jia-Tong-Xie-Yao-Fang Restores the Intestinal Barrier to Alleviate Irritable Bowel Syndrome Via Microbial Butyrate Mediated Pi3k/Akt Pathway Suppression

Published: Jan. 1, 2024

Language: Английский

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