Chitosan oligosaccharide alleviates DON-induced liver injury via suppressing ferroptosis in mice DOI Creative Commons
Mengjie Liu, Zhenlin Li, Jie Li

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 290, P. 117530 - 117530

Published: Dec. 13, 2024

Language: Английский

Hesperidin alleviates kidney injury induced by nano-copper through regulating endoplasmic reticulum stress and autophagy via AMPK-AKT/mTOR pathway in broiler chicken DOI

Lijiao Zhao,

Heyun Zhu,

Haoye Li

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 105980 - 105980

Published: Jan. 1, 2025

Language: Английский

Citations

0
Natural Phenolic Compounds against Trichothecenes: From Protective Mechanisms to Future Perspectives DOI
Aimei Liu, Kan Zhu,

Chenchen Song

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Trichothecenes (TCNs), Fusarium-derived mycotoxins exemplified by deoxynivalenol and T-2 toxin, threaten global health through multisystem toxicity widespread contamination. Natural phenolic compounds (NPCs), leveraging their intrinsic safety natural abundance, demonstrate multimechanistic efficacy in counteracting TCN toxicity. This article reviews both domestic international research on the protective mechanisms of NPCs against TCN-induced exert effects multitiered mechanisms: (1) molecular regulation via Nrf2-centric antioxidant activation MAPK/NF-κB inflammatory axis suppression, coupled with coordinated inhibition programmed cell death pathways (apoptosis/ferroptosis/pyroptosis) autophagy modulation, where GPX4 emerges as a critical ferroptosis regulator; (2) restoring microbiome balance, enhancing intestinal barrier function, optimizing nutrient transport. Gut microflora may also serve an additional target for mitigating TCNs. further inhibit Fusarium proliferation mycotoxin biosynthesis. While there is demonstrated potential food sustainable feed development, challenges persist bioavailability optimization, pharmacokinetic profiling, microbiota-metabolite crosstalk. analysis advances NPC-based strategies detoxification agriculture.

Language: Английский

Citations

0
Hesperidin mitigated deoxynivalenol-induced liver injury by inhibiting ROS/ P53/ PGC-1α-mediated disruption of mitochondrial dynamics and PANoptosis DOI

Xin Wang,

Tong Nie,

Aqun Li

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156747 - 156747

Published: April 1, 2025

Language: Английский

Citations

0
Low-dose deoxynivalenol exposure triggers hepatic excessive ferritinophagy and mitophagy mitigated by hesperidin modulated O-GlcNAcylation DOI
Hao Chen,

Xintong Zhou,

Jun Ma

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 480, P. 135952 - 135952

Published: Sept. 24, 2024

Language: Английский

Citations

3
GSK-3β inhibitor amplifies autophagy-lysosomal pathways by regulating TFEB in Parkinson's disease models DOI

Jiahong Zhong,

Xin Yu,

Yunming Zhong

et al.

Experimental Neurology, Journal Year: 2024, Volume and Issue: 383, P. 115033 - 115033

Published: Oct. 28, 2024

Language: Английский

Citations

1
Chitosan oligosaccharide alleviates DON-induced liver injury via suppressing ferroptosis in mice DOI Creative Commons
Mengjie Liu, Zhenlin Li, Jie Li

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 290, P. 117530 - 117530

Published: Dec. 13, 2024

Language: Английский

Citations

0