Cited by Alcohol aggravates metabolic fatty liver in high-fat diet mice via gut microbiota and metabolite-mediated TLR4/NF-κB and MCT1/GPR pathways

Ginseng-derived nanocellulose alleviates murine colitis through modulation of inflammation, epithelial barrier and gut microbiome DOI

Yali Liu, Zhengwei Zhang,

Shanmin Tao

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 506, P. 160254 - 160254

Published: Jan. 1, 2025

Language: Английский

Citations

Extrusion-cellulase modification of dietary fiber of Flammulina velutipes can enhance prebiotic potential and alleviate lead stress: an in vitro study DOI

Keke Meng, Yifan Wang, Xue Wang

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106522 - 106522

Published: April 1, 2025

Language: Английский

Citations

Investigating the Interaction Between Tangeretin Metabolism and Amelioration of Gut Microbiota Disorders Using Dextran Sulfate Sodium-Induced Colitis and Antibiotic-Associated Diarrhea Models DOI

Jingyi Xu,

Yilu Chen,

Minmin Zhan

et al.

Current Research in Food Science, Journal Year: 2025, Volume and Issue: unknown, P. 101049 - 101049

Published: April 1, 2025

Dysregulation of gut microbiota homeostasis can lead to various health issues. In this study, we investigated the effects tangeretin (TAN) on in a mouse model (C57BL/6J) disease, specifically focusing dextran sulfate sodium (DSS)-induced colitis and antibiotic-associated diarrhea through vitro fermentation intestinal bacteria. Our results demonstrated that TAN effectively improved diversity structure disordered microbiota, increasing levels beneficial bacteria such as Lachnospiraceae Bacteroidaceae, while decreasing harmful Enterococcaceae Pseudomonadaceae. Additionally, enhanced production short-chain fatty acids (SCFAs) microbial communities. Moreover, metabolism by microorganisms yielded two new metabolites, which exhibited an inverse-conjugate (deconjugate) role, leading more functional substances with high bioactivity. These findings provide scientific basis for potential use prebiotic regulate microbiota.

Language: Английский

Citations

Alleviation Effect of the Secondary Metabolite of Anthocyanin (Protocatechuic Acid) on Heterocyclic Amine (IQ)-Induced Liver Injury and Its Underlying Mechanism DOI

Jiang Liu, Yanan Zhao, Lu Chen

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Increased consumption of thermally processed meats caused a high risk accumulation heterocyclic amines (HCAs), which would lead to livery injuries and carcinogenic diseases in daily life. Our previous study found that cyanidin-3-glucoside expressed protective effect on 2-amino-3-methylimidazo [4,5-f] quinoline (IQ)-induced liver injury, but its intrinsic mechanism vivo was unclear. Thus, this aimed at investigating the alleviation secondary metabolite anthocyanin (protocatechuic acid) IQ-induced dysfunction underlying mechanism. The results demonstrated 4 weeks IQ (30 mg/kg) administration C57BL/6 mice induced significant oxidative stress were suppressed by PCA (10 20 supplement. Meanwhile, IQ-mediated inflammation mitigated supplementation via suppressing NF-κB/MAPK pathways signaling. Moreover, supplement significantly reversed intestinal damage tight junction dysfunction. Concurrently, 16s rRNA sequencing data indicated IQ-disturbed SCFAs content gut microbiota. Analysis correlation between microbiota, with manufacturers hepatic dysfunction, underscored significance gut-liver axis PCA-relieved injury stimulated IQ. Taken together, reduced modifying NF-κB/MAPK-NLRP3 inflammatory cascade, controlled barrier failure mediated In summary, our offer new perspectives microbiome-targeted therapeutic strategies for associated

Language: Английский

Citations

Paederia scandens extract alleviates obesity via modulating the gut microbiota and serum metabolome disorder DOI

Yuanyuan Yang, Jiayong Si, Jiayuan Mo

et al.

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: April 23, 2025

Obesity is increasingly becoming a challenge with China's economic development. There an urgent need to identify more affordable methods combat this condition. Paederia scandens (PS), cost-effective herbal remedy widely used in China for treating inflammation and pain, shows potential regard. To investigate its anti-obesity mechanisms, we established high-fat diet (HFD)-induced obesity model mice. The obese mice subsequently received daily oral gavage of PS extract 21 consecutive days. Upon the completion experiment, blood samples were collected analyze lipid profiles, including total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL-C), low-density (LDL-C). Abdominal adipose tissue was subjected hematoxylin-eosin (HE) staining histological analysis, while fecal underwent 16S rRNA sequencing assess gut microbiota composition. Our findings revealed that supplementation significantly reduced body weight, metabolism biomarkers, adipocyte size. treatment also restored microbial diversity, 19 specific taxa 25 KEGG pathways identified as mediators effects. Notably, modulated key obesity-associated microbiota, Alistipes, Lachnoclostridium, Odoribacter, Prevotellaceae UCG-001, Rikenellaceae RC9-gut group, norank_g Bacteroidales S24-7 group. Serum metabolomics analysis implicated L-ascorbic acid, stevioside, allopurinol, gingerol, along amino acid energy pathways, mechanism PS. These results provide novel theoretical insights into therapeutic prevention treatment.

Language: Английский

Citations

Alcohol aggravates metabolic fatty liver in high-fat diet mice via gut microbiota and metabolite-mediated TLR4/NF-κB and MCT1/GPR pathways DOI

Nana Wang,

Chuhan Wang, Xueyan Cao

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: unknown, P. 105816 - 105816

Published: Dec. 1, 2024

Language: Английский

Citations