Structures and Biological Activities of Secondary Metabolites from Daldinia spp. DOI Creative Commons
Miao Yu,

Shi-Ji Chen,

Jueying Shi

et al.

Journal of Fungi, Journal Year: 2024, Volume and Issue: 10(12), P. 833 - 833

Published: Dec. 2, 2024

The genus Daldinia have long been recognized as a source of structural novel, pharmaceutically relevant natural products. We reviewed the structures and activities secondary metabolites isolated from January 1995 to June 2024, 280 compounds, including six major categories—terpenoids, alkaloids, polyketides, polyphenols, steroids, other classes—are presented in this review. Among these metabolites, 196 were identified new structures. Remarkably, 112 compounds exhibited range biological activities, cytotoxic, antimicrobial, anti-inflammatory, antifungal, anti-virus, enzyme-inhibitory activities. This review highlights bioactive discovered past three decades while also exploring potential symbiotic fungi rich sources novel diverse varying bioactivities offer vast array promising lead could significantly contribute development medicines.

Language: Английский

Actinomycetes: Treasure Trove for Discovering Novel Antibiotic Candidates DOI
Rui Yi,

Yutong Shi,

Xun Cao

et al.

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 117317 - 117317

Published: Jan. 1, 2025

Language: Английский

Citations

0
Expression of a Colletotrichum polyketide synthase gene in Aspergillus nidulans leads to unexpected conjugates with a host metabolite DOI Creative Commons

Didier Breyer,

Lu Chen,

Jenny Zhou

et al.

Archives of Microbiology, Journal Year: 2025, Volume and Issue: 207(3)

Published: Feb. 6, 2025

Abstract Heterologous expression of the putative 1,3,6,8-tetrahydroxynaphthalene synthase gene ChPKS from Colletotrichum higginsianum in Aspergillus nidulans led to formation at least eight new compounds. LC-MS analysis proved them as coupling products with an intermediate cichorine biosynthetic pathway. Comprehensive NMR confirmed structures two predominant higginidulans A and B. Deletion backbone pathway host strain abolished higginidulans. alternative Penicillium crustosum resulted expected product 1,3,6,8-tetrahydroxynaphthalene, which was by acetylation structural elucidation. This study provides additional example unexpected natural crosstalk pathways derived different species. Moreover, it highlights importance using systems for expression.

Language: Английский

Citations

0
Structures and Biological Activities of Secondary Metabolites from Daldinia spp. DOI Creative Commons
Miao Yu,

Shi-Ji Chen,

Jueying Shi

et al.

Journal of Fungi, Journal Year: 2024, Volume and Issue: 10(12), P. 833 - 833

Published: Dec. 2, 2024

The genus Daldinia have long been recognized as a source of structural novel, pharmaceutically relevant natural products. We reviewed the structures and activities secondary metabolites isolated from January 1995 to June 2024, 280 compounds, including six major categories—terpenoids, alkaloids, polyketides, polyphenols, steroids, other classes—are presented in this review. Among these metabolites, 196 were identified new structures. Remarkably, 112 compounds exhibited range biological activities, cytotoxic, antimicrobial, anti-inflammatory, antifungal, anti-virus, enzyme-inhibitory activities. This review highlights bioactive discovered past three decades while also exploring potential symbiotic fungi rich sources novel diverse varying bioactivities offer vast array promising lead could significantly contribute development medicines.

Language: Английский

Citations

0