Acanthoside B attenuates NLRP3-mediated pyroptosis and ulcerative colitis through inhibition of tAGE/RAGE pathway

Allergologia et Immunopathologia, Journal Year: 2025, Volume and Issue: 53(1), P. 112 - 122

Published: Jan. 1, 2025

Acanthoside B (Aca.B), a principal bioactive compound extracted from Pogostemon cablin, exhibits superior anti-inflammatory capacity. Ulcerative colitis is nonspecific inflammatory bowel disease with unknown etiology. The potential of Aca.B as therapeutic agent for ulcerative also and remains an area future investigation. In this study, we established both in vitro vivo models to investigate colitis, utilizing Llipopolysaccharide (LPS)-stimulated MODE-K cells dextran sulfate sodium (DSS)-induced mice, respectively. progression was evaluated through histologic analysis, body weight monitoring, assessment activity index assessment. Furthermore, the effects on pyroptosis were detected immunoblot analysis. We found that treatment significantly ameliorated LPS-induced injury cells, evidenced by increased cell viability inhibition response. Moreover, attenuated pyroptosis-specific protein expression, caspase-1 activation, cytokine secretion. animal administration improved symptoms DSS-induced mice model. This accompanied reductionsreduced inweight, colon shortening, infiltration, vivo. diminished accumulation advanced glycation end-products (AGE), resulting decrease expression receptor AGE (RAGE) downstream phosphorylated P65 expression. e.The response depends suppressing AGE/RAGE pathway. study confirms providing fundamental evidence translating into clinical applications medicine.

Language: Английский

Lentinan mitigates ulcerative colitis via the IL-22 pathway to repair the compromised mucosal barrier and enhance antimicrobial defense

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 307, P. 141784 - 141784

Published: March 5, 2025

Language: Английский

Anti-inflammatory effect of food bioactives in Inflammatory Bowel Disease: Role of the gut microbiome

Food Bioscience, Journal Year: 2025, Volume and Issue: 68, P. 106710 - 106710

Published: April 27, 2025

Language: Английский