5‐Demethyl‐Polymethoxyflavones Mitigate Obesity by Reducing Adipose Tissue Inflammation, Promoting Browning, and Modulating Gut Microbiota in High‐Fat Diet‐Fed Mice DOI
Weisheng Lin,

Yu‐Lu Lin,

Yen‐Chun Koh

et al.

Molecular Nutrition & Food Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

ABSTRACT Given the escalating prevalence of obesity worldwide, identifying efficacious dietary components is crucial. This study investigated whether citrus‐derived 5‐demethyl‐polymethoxyflavones (5‐DPMFs) protect against in high‐fat diet (HFD)‐induced obese mice. Male C57BL/6 mice were fed an HFD and supplemented with a powder (CP) containing 5‐DPMFs as main bioactive components. Two doses CP (0.25% 1% diet) tested, corresponding to approximately 36 145 mg/kg body weight 5‐DPMFs, respectively. Key adipose tissue parameters assessed, including inflammatory cytokines browning markers associated p38 MAPK signaling. Treatment significantly attenuated inflammation, evidenced by reduced levels MCP‐1, TNF‐α, IL‐6, IL‐1β. Concurrently, fat was enhanced upregulating thermogenic mitochondrial proteins. Gut microbiota analysis revealed that increased relative abundance beneficial probiotic species, such Lactobacillus Limosilactobacillus reuteri , which have been linked improved metabolic profiles. These findings demonstrate mitigate obesity‐associated promote white (WAT), favorably regulate gut composition HFD‐fed Our results suggest could serve functional food ingredient for prevention management.

Language: Английский

5‐Demethyl‐Polymethoxyflavones Mitigate Obesity by Reducing Adipose Tissue Inflammation, Promoting Browning, and Modulating Gut Microbiota in High‐Fat Diet‐Fed Mice DOI
Weisheng Lin,

Yu‐Lu Lin,

Yen‐Chun Koh

et al.

Molecular Nutrition & Food Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

ABSTRACT Given the escalating prevalence of obesity worldwide, identifying efficacious dietary components is crucial. This study investigated whether citrus‐derived 5‐demethyl‐polymethoxyflavones (5‐DPMFs) protect against in high‐fat diet (HFD)‐induced obese mice. Male C57BL/6 mice were fed an HFD and supplemented with a powder (CP) containing 5‐DPMFs as main bioactive components. Two doses CP (0.25% 1% diet) tested, corresponding to approximately 36 145 mg/kg body weight 5‐DPMFs, respectively. Key adipose tissue parameters assessed, including inflammatory cytokines browning markers associated p38 MAPK signaling. Treatment significantly attenuated inflammation, evidenced by reduced levels MCP‐1, TNF‐α, IL‐6, IL‐1β. Concurrently, fat was enhanced upregulating thermogenic mitochondrial proteins. Gut microbiota analysis revealed that increased relative abundance beneficial probiotic species, such Lactobacillus Limosilactobacillus reuteri , which have been linked improved metabolic profiles. These findings demonstrate mitigate obesity‐associated promote white (WAT), favorably regulate gut composition HFD‐fed Our results suggest could serve functional food ingredient for prevention management.

Language: Английский

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