Discovery of Potential Antifungal Agents: Chalcone Derivatives Containing Thiourea and Piperidine Moieties DOI
Hui Xin, Yi Liu,

Tianyu Deng

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Twenty-two chalcone derivatives containing thiourea and piperidine moieties were synthesized. The in vitro antifungal activities of these compounds against nine fungi evaluated. results demonstrated that a majority exhibited exceptional activities. Especially, K2 displayed the most potent fungicidal activity Phytophthora capsici (P. capsici), with half-effective concentration (EC50) 5.96 μg/mL, surpassing control drug azoxystrobin (Az, 25.2 μg/mL). vivo experiments conducted on pepper leaves fruits. It significant protective efficacy P. (95.3%) at 200 which surpassed Az (79.0%). Morphological investigations utilizing scanning electron microscopy (SEM) fluorescence (FM) unveiled disruptive impact mycelium. Moreover, mechanistic studies have capacity to disrupt integrity cellular membrane pathogenic fungi, influence lipid peroxidation processes within membrane, induce content release. These experimental findings provided new idea for effectively preventing plant fungal diseases developing novel green chemical pesticide products.

Language: Английский

Discovery of Potential Antifungal Agents: Chalcone Derivatives Containing Thiourea and Piperidine Moieties DOI
Hui Xin, Yi Liu,

Tianyu Deng

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Twenty-two chalcone derivatives containing thiourea and piperidine moieties were synthesized. The in vitro antifungal activities of these compounds against nine fungi evaluated. results demonstrated that a majority exhibited exceptional activities. Especially, K2 displayed the most potent fungicidal activity Phytophthora capsici (P. capsici), with half-effective concentration (EC50) 5.96 μg/mL, surpassing control drug azoxystrobin (Az, 25.2 μg/mL). vivo experiments conducted on pepper leaves fruits. It significant protective efficacy P. (95.3%) at 200 which surpassed Az (79.0%). Morphological investigations utilizing scanning electron microscopy (SEM) fluorescence (FM) unveiled disruptive impact mycelium. Moreover, mechanistic studies have capacity to disrupt integrity cellular membrane pathogenic fungi, influence lipid peroxidation processes within membrane, induce content release. These experimental findings provided new idea for effectively preventing plant fungal diseases developing novel green chemical pesticide products.

Language: Английский

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