Unveiling the microbial orchestra: exploring the role of microbiota in cancer development and treatment DOI Creative Commons
Esther Ugo Alum,

Daniel Ejim Uti,

Okechukwu Paul-Chima Ugwu

et al.

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 30, 2025

The human microbiota comprises a diverse microbial ecosystem that significantly impacts health and disease. Among its components, the gut plays crucial role in regulating metabolic, immunologic, inflammatory responses. Dysbiosis, an imbalance composition, has been linked to carcinogenesis through mechanisms such as chronic inflammation, metabolic disturbances, epigenetic modifications, immune system dysregulation. Additionally, dysbiosis influences efficacy toxicity of cancer therapies. Given these associations, there is growing interest leveraging biomarker for detection outcome prediction. Notably, distinct signatures have identified across various types, suggesting their potential diagnostic markers. Furthermore, modulation presents promising avenue improving treatment outcomes strategies antibiotics, prebiotics, probiotics, fecal transplantation, dietary interventions, small-molecule inhibitors, phage therapy. To explore relationships, we conducted comprehensive literature review using Web Science, Scopus, PubMed, MEDLINE, Embase, Google Scholar our primary online databases, focusing on indexed peer-reviewed articles up present year. This aims elucidate development, examine molecular involved, assess impact highlight microbiota-based therapeutic discuss applications management. A deeper understanding intricate interplay between may pave way novel approaches prevention, early detection, optimization.

Language: Английский

A review on probiotics and dietary bioactives: Insights on metabolic well-being, gut microbiota, and inflammatory responses DOI Creative Commons
Alice Njolke Mafe, Great Iruoghene Edo,

Osamah S. Majeed

et al.

Food Chemistry Advances, Journal Year: 2025, Volume and Issue: 6, P. 100919 - 100919

Published: Feb. 11, 2025

Language: Английский

Citations

6
Microbiome-Driven Therapeutics: From Gut Health to Precision Medicine DOI Creative Commons
Muneer Yaqub,

Aashika Jain,

Chinedu Eucharia Joseph

et al.

Gastrointestinal Disorders, Journal Year: 2025, Volume and Issue: 7(1), P. 7 - 7

Published: Jan. 15, 2025

The human microbiome, a complex ecosystem of microorganisms residing in and on the body, plays pivotal role regulation wide range physiological processes, including digestion, immune responses, metabolic functions. In recent years, rapidly growing field microbiome-driven therapeutics has garnered significant attention owing to its potential revolutionize healthcare. This review explores evolving landscape microbiome-based therapies, with particular focus gut microbiome implications for both health precision medicine. We highlight advances understanding how microbial communities influence disease pathogenesis treatment outcomes, spanning conditions such as inflammatory bowel (IBD), disorders, neurological diseases, even cancer. article also discusses emerging therapeutic strategies, probiotics, prebiotics, fecal microbiota transplantation (FMT), microbial-based drugs, well challenges associated their clinical implementation. Additionally, we examined integration profiling metagenomic data is advancing medicine, paving way personalized effective treatments. serves comprehensive resource that synthesizes current knowledge, identifies key gaps research, offers insights into future direction therapeutics, thus providing valuable framework clinicians, researchers, policymakers seeking harness microbiomes advance healthcare solutions.

Language: Английский

Citations

2
Gut Microbiota Modulation in IBD: From the Old Paradigm to Revolutionary Tools DOI Open Access

Marco Murgiano,

Bianca Bartocci, Pierluigi Puca

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3059 - 3059

Published: March 27, 2025

Inflammatory bowel diseases (IBDs) are chronic inflammatory disorders primarily comprising two main conditions: ulcerative colitis and Crohn’s disease. The gut microbiota’s role in driving inflammation IBD has garnered significant attention, yet the precise mechanisms through which microbiota influences pathogenesis remain largely unclear. Given limited therapeutic options for IBD, alternative microbiota-targeted therapies—including prebiotics, probiotics, postbiotics, symbiotics—have been proposed. While these approaches have shown promising results, modulation is still mainly considered an adjunct therapy to conventional treatments, with a demonstrated impact on patients’ quality of life. Fecal transplantation (FMT), already approved treating Clostridioides difficile infection, represents first series innovative microbiota-based therapies under investigation. Microbial biotherapeutics emerging as personalized cutting-edge tools management, encompassing next-generation bacterial consortia, bacteriophages, engineered direct metabolic pathway modulation, nanotherapeutics. This review explores microbial strategy IBDs, highlighting current examining development better understand their potential clinical applications managing intestinal disorders.

Language: Английский

Citations

0
Recent advances in therapeutic probiotics: insights from human trials DOI
Mu-Yeol Cho,

Jeong-Sik Eom,

Eun-Mi Choi

et al.

Clinical Microbiology Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

SUMMARY Recent advances in therapeutic probiotics have shown promising results across various health conditions, reflecting a growing understanding of the human microbiome’s role and disease. However, comprehensive reviews integrating diverse effects subjects been limited. By analyzing randomized controlled trials (RCTs) meta-analyses, this review provides overview key developments probiotic interventions targeting gut, liver, skin, vaginal, mental, oral health. Emerging evidence supports efficacy specific strains combinations treating wide range disorders, from gastrointestinal (GI) liver diseases to dermatological bacterial vaginosis, mental diseases. We discuss expanding microbiome-organ connections underlying mechanisms action. While many clinical demonstrate significant benefits, we acknowledge areas requiring further large-scale studies establish definitive optimal treatment protocols. The addresses challenges standardizing research methodologies emphasizes importance considering individual variations microbiome composition host genetics. Additionally, explore emerging concepts such as oral-gut-brain axis future directions, including high-resolution profiling, host-microbe interaction studies, organoid models, artificial intelligence applications research. Overall, offers update on current state multiple domains health, providing insights into directions potential for revolutionize preventive medicine.

Language: Английский

Citations

0
Unveiling the microbial orchestra: exploring the role of microbiota in cancer development and treatment DOI Creative Commons
Esther Ugo Alum,

Daniel Ejim Uti,

Okechukwu Paul-Chima Ugwu

et al.

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 30, 2025

The human microbiota comprises a diverse microbial ecosystem that significantly impacts health and disease. Among its components, the gut plays crucial role in regulating metabolic, immunologic, inflammatory responses. Dysbiosis, an imbalance composition, has been linked to carcinogenesis through mechanisms such as chronic inflammation, metabolic disturbances, epigenetic modifications, immune system dysregulation. Additionally, dysbiosis influences efficacy toxicity of cancer therapies. Given these associations, there is growing interest leveraging biomarker for detection outcome prediction. Notably, distinct signatures have identified across various types, suggesting their potential diagnostic markers. Furthermore, modulation presents promising avenue improving treatment outcomes strategies antibiotics, prebiotics, probiotics, fecal transplantation, dietary interventions, small-molecule inhibitors, phage therapy. To explore relationships, we conducted comprehensive literature review using Web Science, Scopus, PubMed, MEDLINE, Embase, Google Scholar our primary online databases, focusing on indexed peer-reviewed articles up present year. This aims elucidate development, examine molecular involved, assess impact highlight microbiota-based therapeutic discuss applications management. A deeper understanding intricate interplay between may pave way novel approaches prevention, early detection, optimization.

Language: Английский

Citations

0