Improvement in Heat Stress-Induced Damage to Sperm Quality Following Fecal Microbiota Transplantation from L-Arginine-Treated Mice DOI Creative Commons
Kai Wang,

Yunpeng Suo,

Dan Shen

et al.

Animals, Journal Year: 2025, Volume and Issue: 15(6), P. 796 - 796

Published: March 11, 2025

Heat stress has become a significant concern in animal husbandry, as it adversely affects reproductive performance, particularly sperm quality, through mechanisms that are not fully understood. This study aimed to investigate the protective effects of L-arginine against heat stress-induced damage and explore its potential modulation intestinal microbiota. consisted two experiments. First, heat-stressed mouse model, was administered evaluate on health mice. In second experiment, by transplanting L-arginine-induced changes gut microbiota into mice, mice were assessed. The findings revealed amelioration decreased quality testicular injury induced stress. Post stress, supplemented with presented an increase seminal vesicle gland weight index, partial alleviation tissue morphology, substantial testosterone concentration (p < 0.05). Additionally, upregulated expression synthesis genes mRNA levels generation-related genes, including 3β-HSD, Stra8, WT1, Gdnf Concurrently, microbial communities mitigated decreases injury, coupled increases Cyp17a1, 17β-HSD, Plzf, Furthermore, there reduction proinflammatory factors, namely, NFκB, MyD88, TNF-α, TGF-β3 conclusion, may influence ratio beneficial bacteria harmful microbiota, thereby reducing inflammation caused maintaining health, influencing microenvironment for spermatogenesis.

Language: Английский

Improvement in Heat Stress-Induced Damage to Sperm Quality Following Fecal Microbiota Transplantation from L-Arginine-Treated Mice DOI Creative Commons
Kai Wang,

Yunpeng Suo,

Dan Shen

et al.

Animals, Journal Year: 2025, Volume and Issue: 15(6), P. 796 - 796

Published: March 11, 2025

Heat stress has become a significant concern in animal husbandry, as it adversely affects reproductive performance, particularly sperm quality, through mechanisms that are not fully understood. This study aimed to investigate the protective effects of L-arginine against heat stress-induced damage and explore its potential modulation intestinal microbiota. consisted two experiments. First, heat-stressed mouse model, was administered evaluate on health mice. In second experiment, by transplanting L-arginine-induced changes gut microbiota into mice, mice were assessed. The findings revealed amelioration decreased quality testicular injury induced stress. Post stress, supplemented with presented an increase seminal vesicle gland weight index, partial alleviation tissue morphology, substantial testosterone concentration (p < 0.05). Additionally, upregulated expression synthesis genes mRNA levels generation-related genes, including 3β-HSD, Stra8, WT1, Gdnf Concurrently, microbial communities mitigated decreases injury, coupled increases Cyp17a1, 17β-HSD, Plzf, Furthermore, there reduction proinflammatory factors, namely, NFκB, MyD88, TNF-α, TGF-β3 conclusion, may influence ratio beneficial bacteria harmful microbiota, thereby reducing inflammation caused maintaining health, influencing microenvironment for spermatogenesis.

Language: Английский

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