Discovery of Coumarin-7-N/O-Acethydrazide Derivatives as Novel Antifungal and Herbicidal Agents DOI
Yufei Li, Shanshan Yang, Yifan Zheng

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: June 3, 2025

Natural products (NPs) have attracted increasing attention due to their structural diversity, abundance, and low environmental impact, making them valuable for novel fungicide development. In this study, a series of coumarin-7-N/O acethydrazide derivatives were synthesized by incorporating acetic acid moieties into the coumarin scaffold. The in vitro antifungal activities these compounds evaluated against six common plant pathogenic fungi. Compound B13 demonstrated significant effects, with EC50 values 3.24, 1.89, 1.70, 0.36, 4.27, 1.50 μg/mL Botrytis cinerea, Alternaria solani, Fusarium graminearum, Rhizoctonia Colletotrichum orbiculare alternata, respectively. Notably, activity R. solani was comparable commercial boscalid (EC50 = 0.31 μg/mL), while A. alternata significantly higher than that 13.60 2.55 μg/mL, respectively), Furthermore, vivo assays protective efficacy at 200 (86.9%) Validamycin (92.1%). inhibitory effects further confirmed through scanning electron microscopy fluorescence microscopy. influence charge distribution compound on its investigated using Density Functional Theory (DFT). Meanwhile, some exhibited herbicidal four field weeds. These results indicate is promising candidate crop protection, exhibiting high toxicity.

Language: Английский

Inhibition of Glucosinolate Sulfatases to Combat Plutella xylostella: Development of Novel Phenylcarboxamide Derivatives for Plant-Integrated Pest Management DOI
Jiali Wang, Min Wang,

Anil Ravi

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Glucosinolates in cruciferous plants are hydrolyzed by myrosinase to produce toxic isothiocyanates (ITCs). However, Plutella xylostella (P. xylostella), one of the top 10 global agricultural pests, utilizes glucosinolate sulfatases (GSSs) its gut convert glucosinolates into nontoxic desulfo-glucosinolates, thereby effectively avoiding toxicity ITCs. This study investigates potential inhibiting GSSs. Among 16 synthesized phenylcarboxamide derivatives, compound 1n exhibited strong inhibitory activity against GSS1 (59.72%) and GSS2 (88.47%), key enzymes involved desulfation P. xylostella, leading ITC accumulation disrupted detoxification. resulted an approximately 30% reduction larval weight, at a concentration 100 mg/L, mortality rate reached 96%. Importantly, absence glucosinolates, these inhibitors showed no direct insect, indicating that their action relies on interaction with plant's chemical defense system. These findings provide evidence supporting development GSSs inhibitions as more specific selective insecticide, offering promising alternative conventional pesticides.

Language: Английский

Citations

0
Discovery of Coumarin-7-N/O-Acethydrazide Derivatives as Novel Antifungal and Herbicidal Agents DOI
Yufei Li, Shanshan Yang, Yifan Zheng

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: June 3, 2025

Natural products (NPs) have attracted increasing attention due to their structural diversity, abundance, and low environmental impact, making them valuable for novel fungicide development. In this study, a series of coumarin-7-N/O acethydrazide derivatives were synthesized by incorporating acetic acid moieties into the coumarin scaffold. The in vitro antifungal activities these compounds evaluated against six common plant pathogenic fungi. Compound B13 demonstrated significant effects, with EC50 values 3.24, 1.89, 1.70, 0.36, 4.27, 1.50 μg/mL Botrytis cinerea, Alternaria solani, Fusarium graminearum, Rhizoctonia Colletotrichum orbiculare alternata, respectively. Notably, activity R. solani was comparable commercial boscalid (EC50 = 0.31 μg/mL), while A. alternata significantly higher than that 13.60 2.55 μg/mL, respectively), Furthermore, vivo assays protective efficacy at 200 (86.9%) Validamycin (92.1%). inhibitory effects further confirmed through scanning electron microscopy fluorescence microscopy. influence charge distribution compound on its investigated using Density Functional Theory (DFT). Meanwhile, some exhibited herbicidal four field weeds. These results indicate is promising candidate crop protection, exhibiting high toxicity.

Language: Английский

Citations

0