Biomedicine & Pharmacotherapy,
Journal Year:
2021,
Volume and Issue:
144, P. 112328 - 112328
Published: Oct. 14, 2021
Cisplatin
is
a
potent
platinum-based
anticancer
drug
approved
by
the
Food
Drug
Administration
(FDA)
in
1978.
Despite
its
advantages
against
solid
tumors,
cisplatin
confers
toxicity
to
various
tissues
that
limit
clinical
uses.
In
cisplatin-induced
hepatotoxicity,
few
mechanisms
have
been
identified,
which
started
as
excess
generation
of
reactive
oxygen
species
leads
oxidative
stress,
inflammation,
DNA
damage
and
apoptosis
liver.
Various
natural
products,
plant
extracts
oil
rich
flavonoids,
terpenoids,
polyphenols,
phenolic
acids
were
able
minimize
stress
restoring
level
antioxidant
enzymes
acting
an
anti-inflammatory
agent.
Likewise,
treatment
with
honey
royal
jelly
was
demonstrated
decrease
serum
transaminases
scavenge
free
radicals
liver
after
administration.
Medicinal
properties
these
products
promising
potential
complementary
therapy
counteract
hepatotoxicity.
This
review
concentrated
on
protective
role
several
has
proven
laboratory
findings
combat
Journal of Agricultural and Food Chemistry,
Journal Year:
2019,
Volume and Issue:
67(26), P. 7325 - 7335
Published: June 11, 2019
Tea
polyphenols
(TP)
possess
the
ability
to
regulate
dyslipidemia
and
gut
microbiota
dysbiosis.
However,
underlying
mechanism
is
still
elusive.
The
present
study
explored
intervention
of
TP
on
high
fat
diet
induced
metabolic
disorders,
dysbiosis
in
mice,
intestinal
mechanism.
As
a
result,
significantly
ameliorated
hyperlipidemia,
improved
expression
levels
hepatic
lipid
metabolism
genes,
modulated
microbiota.
was
supposed
rely
maintaining
redox
state
by
TP.
Intestinal
related
indicators
were
correlated
with
distribution
An
unidentified
genus
Lachnospiraceae,
Bacteroides,
Alistipes,
Faecalibaculum
identified
as
biomarkers
for
state.
Importantly,
different
dosages
varied
patterns,
an
overdose
intake
attenuated
beneficial
effects
health.
Our
findings
offered
novel
insights
into
homeostasis.
International Journal of Molecular Sciences,
Journal Year:
2020,
Volume and Issue:
21(14), P. 5171 - 5171
Published: July 21, 2020
Some
coronavirus
disease
2019
(COVID-19)
patients
develop
acute
pneumonia
which
can
result
in
a
cytokine
storm
syndrome
response
to
Severe
Acute
Respiratory
Syndrome
2
(SARS-CoV-2)
infection.
The
most
effective
anti-inflammatory
drugs
employed
so
far
severe
COVID-19
belong
the
cytokine-directed
biological
agents,
widely
used
management
of
many
autoimmune
diseases.
In
this
paper
we
analyze
efficacy
epigallocatechin
3-gallate
(EGCG),
abundant
ingredient
green
tea
leaves
and
well-known
antioxidant,
counteracting
diseases,
are
dominated
by
massive
cytokines
production.
Indeed,
studies
registered
that
EGCG
inhibits
signal
transducer
activator
transcription
(STAT)1/3
nuclear
factor
kappa-light-chain-enhancer
activated
B
cells
(NF-κB)
factors,
whose
activities
crucial
multiplicity
downstream
pro-inflammatory
signaling
pathways.
Importantly,
safety
EGCG/green
extract
supplementation
is
well
documented
clinical
trials,
as
discussed
review.
Since
restore
natural
immunological
homeostasis
different
propose
here
therapy
with
patients.
Besides
some
antiviral
anti-sepsis
actions,
major
benefits
lie
its
anti-fibrotic
effect
ability
simultaneously
downregulate
expression
inflammatory
mediators.
conclusion,
be
considered
potential
safe
supplement
counteract
hyper-inflammation
growing
COVID-19.
International Journal of Molecular Sciences,
Journal Year:
2021,
Volume and Issue:
22(17), P. 9109 - 9109
Published: Aug. 24, 2021
Tea
is
particularly
rich
in
polyphenols,
including
catechins
and
theaflavins,
thearubigins,
flavonols,
phenolic
acids,
which
are
believed
to
contribute
the
health
benefits
of
tea.
The
health-promoting
effects
tea
polyphenols
be
related
their
cellular
defensive
properties.
This
review
intended
briefly
summarize
relationship
between
chemical
structures
biological
activities.
appear
as
direct
antioxidants
by
scavenging
reactive
oxygen/nitrogen
species;
chelating
transition
metals;
inhibiting
lipid,
protein,
DNA
oxidations.
They
also
act
directly
suppressing
"pro-oxidant"
enzymes,
inducing
endogenous
antioxidants,
cooperating
with
vitamins.
Moreover,
regulate
signaling
transduction
pathways,
importantly
contributing
prevention
chronic
diseases
promotion
physiological
functions.
Apparently,
features
closely
associated
antioxidant
potentials.
Biomedicine & Pharmacotherapy,
Journal Year:
2021,
Volume and Issue:
144, P. 112328 - 112328
Published: Oct. 14, 2021
Cisplatin
is
a
potent
platinum-based
anticancer
drug
approved
by
the
Food
Drug
Administration
(FDA)
in
1978.
Despite
its
advantages
against
solid
tumors,
cisplatin
confers
toxicity
to
various
tissues
that
limit
clinical
uses.
In
cisplatin-induced
hepatotoxicity,
few
mechanisms
have
been
identified,
which
started
as
excess
generation
of
reactive
oxygen
species
leads
oxidative
stress,
inflammation,
DNA
damage
and
apoptosis
liver.
Various
natural
products,
plant
extracts
oil
rich
flavonoids,
terpenoids,
polyphenols,
phenolic
acids
were
able
minimize
stress
restoring
level
antioxidant
enzymes
acting
an
anti-inflammatory
agent.
Likewise,
treatment
with
honey
royal
jelly
was
demonstrated
decrease
serum
transaminases
scavenge
free
radicals
liver
after
administration.
Medicinal
properties
these
products
promising
potential
complementary
therapy
counteract
hepatotoxicity.
This
review
concentrated
on
protective
role
several
has
proven
laboratory
findings
combat
