A Mini-Review on Enhancing Solubility in Topical Hydrogel Formulations Using Solid Dispersion Technology for Poorly Water-Soluble Drugs DOI Creative Commons

Zaid Dahma,

Covadonga Álvarez-Álvarez, Paloma Marina de la Torre-Iglesias

et al.

Colloids and Interfaces, Journal Year: 2025, Volume and Issue: 9(2), P. 17 - 17

Published: March 21, 2025

The solubility behavior of drugs is a critical factor in formulation development. Approximately 40–45% new face market entry challenges due to low water solubility. Enhancing drug bioavailability thus essential developing pharmaceutical dosage forms. Many biopharmaceutical class II and IV are commonly prescribed treat inflammations, infections, pain from various pathologies. Their oral administration has several drawbacks, including significant first-pass liver effects, bioavailability, adverse gastrointestinal effects. Topical application gained relevance its advantages delivering directly the target site, avoiding irritation, increasing their effectiveness. However, topical hydrogel formulations with poorly water-soluble related skin’s permeability. Therefore, preparing hydrogels using solid dispersions (SDs) an effective strategy enhance dissolution rate soluble drugs, thereby improving bioavailability. In this review, concepts SDs, delivery systems, incorporating as well preparation methods, characterization, applications, will be discussed.

Language: Английский

A Mini-Review on Enhancing Solubility in Topical Hydrogel Formulations Using Solid Dispersion Technology for Poorly Water-Soluble Drugs DOI Creative Commons

Zaid Dahma,

Covadonga Álvarez-Álvarez, Paloma Marina de la Torre-Iglesias

et al.

Colloids and Interfaces, Journal Year: 2025, Volume and Issue: 9(2), P. 17 - 17

Published: March 21, 2025

The solubility behavior of drugs is a critical factor in formulation development. Approximately 40–45% new face market entry challenges due to low water solubility. Enhancing drug bioavailability thus essential developing pharmaceutical dosage forms. Many biopharmaceutical class II and IV are commonly prescribed treat inflammations, infections, pain from various pathologies. Their oral administration has several drawbacks, including significant first-pass liver effects, bioavailability, adverse gastrointestinal effects. Topical application gained relevance its advantages delivering directly the target site, avoiding irritation, increasing their effectiveness. However, topical hydrogel formulations with poorly water-soluble related skin’s permeability. Therefore, preparing hydrogels using solid dispersions (SDs) an effective strategy enhance dissolution rate soluble drugs, thereby improving bioavailability. In this review, concepts SDs, delivery systems, incorporating as well preparation methods, characterization, applications, will be discussed.

Language: Английский

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