Design of Cell-Specific Targeting Peptides for Cancer Therapy DOI Open Access
Xiaoyong Chen, Di Wang, Yun‐Bao Jiang

et al.

Targets, Journal Year: 2024, Volume and Issue: 2(3), P. 186 - 201

Published: July 27, 2024

The landscape of cancer therapy has gained major impetus through the development materials capable selectively targeting cells while sparing normal cells. Synthetic peptides are appealing as scaffolds for creation such materials. They small in size, amenable to chemical synthesis and functionalization, possess diverse structural space modulating properties. Here, we review some fundamental insights into design, discovery, evolution peptide-based agents, with a particular focus on two types cell targets: unique/overexpressed surface receptors abnormal physiological We highlight cutting-edge strategies from literature last decades that demonstrate innovative approaches constructing receptor-specific cyclic binders stimulus-responsive Additionally, discuss potential future directions advancing this field, aim pushing frontiers targeted forward.

Language: Английский

Self-Assembly of Multimolecular Components for Engineering Enzyme-Mimetic Materials DOI
Shichao Xu, Yuanxi Liu, Baoli Zhang

et al.

Accounts of Materials Research, Journal Year: 2024, Volume and Issue: 5(9), P. 1072 - 1086

Published: July 4, 2024

ConspectusNatural enzymes, with their intricate three-dimensional structures, facilitate a wide array of biochemical reactions exceptional precision and speed. The catalytic capabilities enzymes arise from the distinctive structures active sites, where functional groups collaborate or aid cofactors (organic ionic) in binding substrates specificity catalyzing transformations. Inspired by structure–function relationship supramolecular self-assembly, bottom-up approach nanofabrication, has been employed to create enzyme-mimetic catalysts. However, accurately replicating enzymatic sites poses formidable challenge, primarily because intricacies mimicking complexity natural protein folding.Many biological systems, such as tryptophan synthase ribosomes, rely on association multiple component subunits, each maintaining its structural integrity, enable efficient versatile functionalities. hierarchical self-assembly principles observed these systems have inspired us design self-assemble complementary molecular building blocks that form individual folding aggregating allowing for precise control over distribution reactive enzyme-like sites. customization either without disrupting enables flexible engineering properties. This Account will focus employing components, drawing research progress our lab, construct catalysts built-in metal-dependent metal-free be highlighted.To fabricate heme pockets copper within synthetic materials, we scaffold stabilizing hemin forming cluster, followed introduction second enhance substrate adsorption metal reactivity. resulting enzyme mimics exhibit remarkable synergistic activities possess great stability against harsh conditions, high temperatures, ionic strength, cyclic acidification/neutralization treatment. They can engineered tailorable selectivity toward specific chirality sizes externally stimulated switch between ON/OFF states. These shown performances sensing biomolecules interest, biomass degradation, aiding understanding mechanism native enzymes. To achieve catalysis, introduce "driving" guide formation assemblies activity hydrolases, photodecarboxylase, photo-oxidase, applications peptide modifications antibacterial therapy. Moreover, organized components like histidine catalyze achieved heme-dependent providing insights into novel biocatalytic mechanisms. Additionally, discuss DNAzyme units DNA nanostructured templates, which provide suitable microenvironments fabrication polymer nanopattern well-defined shapes.In end, key challenges related modeling, enhancing performance, increasing We also propose future perspectives achieving high-value practical applications. Our collective efforts outline strategies developing robust catalysts, general methods may extend other aiming mimic catalysis.

Language: Английский

Citations

3
Fundamental and Application of Co-assembly of Peptides and Proteins: Experiment and Computation DOI Creative Commons

Newton A. Ihoeghian,

Qing Shao

Supramolecular Materials, Journal Year: 2025, Volume and Issue: unknown, P. 100103 - 100103

Published: April 1, 2025

Language: Английский

Citations

0
Biomolecular Actuators for Soft Robots DOI
Martin Quan, J. Danielle

Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: May 7, 2025

Biomolecules present promising stimuli-responsive mechanisms to revolutionize soft actuators. Proteins, peptides, and nucleic acids foster specific intermolecular interactions, their boundless sequence design spaces encode precise actuation capabilities. Drawing inspiration from nature, biomolecular actuators harness existing properties meet the needs of diverse applications. This review features that respond a wide variety stimuli drive both user-directed autonomous actuation. We discuss how advances in biomaterial fabrication accelerate prototyping precise, custom actuators, we identify biomolecules with untapped potential. Finally, highlight opportunities for multifunctional reconfigurable improve versatility sustainability next-generation

Language: Английский

Citations

0
Synthetic Nanoassemblies for Regulating Organelles: From Molecular Design to Precision Therapeutics DOI
Yanfei Guo, Peiran Li,

Xiaocui Guo

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(44), P. 30224 - 30246

Published: Oct. 23, 2024

Each organelle referring to a complex multiorder architecture executes respective biological processes via its distinct spatial organization and internal microenvironment. As the assembly of biomolecules is structural basis living cells, creating synthetic nanoassemblies with specific physicochemical morphological properties in cells interfere or couple natural architectures has attracted great attention precision therapeutics cancers. In this review, we give an overview latest advances for precise regulation, including formation mechanisms, triggering strategies, biomedical applications therapeutics. We summarize emerging material systems, polymers, peptides, deoxyribonucleic acids (DNAs), their intermolecular interactions intercellular nanoassemblies, highlight design principles constructing precursors that assemble into targeting organelles cellular environment. further showcase developed intracellular mitochondria, endoplasmic reticulum, lysosome, Golgi apparatus, nucleus describe underlying mechanisms regulation cancer. Last, essential challenges field prospects future are discussed. This review should facilitate rational organelle-targeting comprehensive recognition by materials contribute deep understanding application

Language: Английский

Citations

3
Nanomaterials and methods for cancer therapy: 2D materials, biomolecules, and molecular dynamics simulations DOI
Welela Meka Kedir, Lunna Li, Yaw Sing Tan

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Nanomaterials made from 2D semiconductors and biomolecules are reviewed. Cell-nanoparticle interactions examined in recent simulations. These nanomaterials MD simulations reveal novel mechanisms enable cancer drug delivery targeting.

Language: Английский

Citations

2
Design of Cell-Specific Targeting Peptides for Cancer Therapy DOI Open Access
Xiaoyong Chen, Di Wang, Yun‐Bao Jiang

et al.

Targets, Journal Year: 2024, Volume and Issue: 2(3), P. 186 - 201

Published: July 27, 2024

The landscape of cancer therapy has gained major impetus through the development materials capable selectively targeting cells while sparing normal cells. Synthetic peptides are appealing as scaffolds for creation such materials. They small in size, amenable to chemical synthesis and functionalization, possess diverse structural space modulating properties. Here, we review some fundamental insights into design, discovery, evolution peptide-based agents, with a particular focus on two types cell targets: unique/overexpressed surface receptors abnormal physiological We highlight cutting-edge strategies from literature last decades that demonstrate innovative approaches constructing receptor-specific cyclic binders stimulus-responsive Additionally, discuss potential future directions advancing this field, aim pushing frontiers targeted forward.

Language: Английский

Citations

1