Cited by A correlation of polymorphic G-quadruplex formation in vitro and in the lysosomes of live cancer cells

Diphenylaminothiophen-derived fluorescent ligands targeting mitochondrial DNA G-quadruplexes potentially for triple-negative breast cancer therapy DOI

Rui Wang,

Zhi-Lin Zhang,

Ming-Hao Hu

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 302, P. 140556 - 140556

Published: Jan. 31, 2025

Language: Английский

Citations

Discovery of a mitochondrial G-quadruplex targeted fluorescent ligand via a slight variation on the near-infrared heptamethine cyanine scaffold DOI

Qian-Wen Nie,

Xiao Zhang, Ming-Hao Hu

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 269, P. 132230 - 132230

Published: May 8, 2024

Language: Английский

Citations

Targeting the G-quadruplex as a novel strategy for developing antibiotics against hypervirulent drug-resistant Staphylococcus aureus DOI

M. Sarwat Sultan,

Maria Razzaq, Joohyun Lee

et al.

Journal of Biomedical Science, Journal Year: 2025, Volume and Issue: 32(1)

Published: Feb. 5, 2025

Abstract Background The rapid emergence of multiple drug-resistant (MDR) bacterial pathogens and the lack a novel antibiotic pipeline pose serious threat to global healthcare. limited number established targets further restricts identification antibiotics treat life-threatening MDR infections caused by Staphylococcus aureus strains. Therefore, for developing are urgently required. In this study, we hypothesized that G-quadruplex (G4)-binding ligands can be used as their binding possibly downregulate/block expression vital genes. Methods To test this, first screened properties representative G4-binding against hypervirulent S. USA300 determined in vitro vivo antibacterial activity; proposed mechanism action applying various microbiological, infection, microscopic, biophysicochemical techniques. Results Herein, among ligands, N-methyl mesoporphyrin IX (NMM) showed highest activity USA300. NMM exhibited minimum inhibitory concentration (MIC) 5 μM USA300, impacting cell division wall repressing expressions genes ( dcw ) gene cluster. Genome-wide bioinformatics analysis G4 motifs mapping on genome, identified presence G4-motif promoter mraZ , conserved master regulator cluster regulating coordinated synthesis. Physicochemical assessments using UV–visible, circular dichroism, nuclear magnetic resonance spectroscopy confirmed present formed an intramolecular parallel structure, interacting with NMM. reporter followed coupled transcription/translation (IVT) assays role target impose extreme both gram-positive -negative bacteria. In-cell validation RAW264.7 cells Galleria mellonella ; respectively, demonstrated superior compared well-established antibiotics, no observed cytotoxicity. Conclusions summary, current study broad-spectrum potent agent elucidated its plausible primarily targeting

Language: Английский

Citations

Mitochondrial DNA-targeted triphenylamine-thiophene (TPATP)-derived ligands boost type-I/II photodynamic therapy for triple-negative breast cancer DOI

Xiaodong Wang,

Yong-Si Liu,

Zhipin Liang

et al.

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 289, P. 117489 - 117489

Published: March 7, 2025

Language: Английский

Citations

G-quadruplex in cancer energy metabolism: A potential therapeutic target DOI

Zongqiang Han,

Lina Wen

Biochimica et Biophysica Acta (BBA) - General Subjects, Journal Year: 2025, Volume and Issue: unknown, P. 130810 - 130810

Published: April 1, 2025

Language: Английский

Citations

Design and synthesis of novel mitochondria-targeted ergosterol peroxide derivatives as potential anti-cancer agents DOI

Lu Wang,

Shuang Tian,

Siqi Deng

et al.

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 153, P. 107862 - 107862

Published: Oct. 1, 2024

Language: Английский

Citations

A highly emissive near infrared thiophene-benzoindolium ligand binding to mitochondrial G-quadruplexes triggers triple-negative breast cancer cell death DOI

Xiaodong Wang,

Yong-Si Liu,

Ming-Hao Hu

et al.

Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 418, P. 136350 - 136350

Published: July 23, 2024

Language: Английский

Citations

A NRAS mRNA G-quadruplex structure-targeting small-molecule ligand reactivating DNA damage response in human cancer cells for combination therapy with clinical PI3K inhibitors DOI

Ka-Hin Chan,

Bo‐Xin Zheng,

Alan Siu‐Lun Leung

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 279, P. 135308 - 135308

Published: Sept. 6, 2024

Language: Английский

Citations

Insight into Stabilization of G‐Quadruplex in c‐MYC Region with Phenanthroimidazoisoindol‐Acrylates and their Binding Behaviour towards Human Serum Albumin DOI

Rekha Thakur,

Vijay Luxami, Kamaldeep Paul

et al.

ChemMedChem, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

The interaction of G-quadruplex (non-canonical DNA) with suitable compounds for their stabilization at the promoter region oncogenes has become a potential anticancer approach. We have studied phenanthroimidazoisoindol-acrylates derivatives c-MYC G-quadruplex. A series 20 were evaluated activity against human cancer cell lines, where 3 fa, ha, and ae shown broad-spectrum activities most lines inactive towards normal lines. Various spectroscopic techniques been used to study these compounds. studies reveal strong binding all three significant selectivity over dsDNA, constant order 10

Language: Английский

Citations

A correlation of polymorphic G-quadruplex formation in vitro and in the lysosomes of live cancer cells DOI

Ting‐Yuan Tseng, Ta‐Chau Chang, Ji‐Yen Cheng

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 138899 - 138899

Published: Dec. 1, 2024

Language: Английский

Citations