Future Medicinal Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 23
Published: Dec. 22, 2024
Organoselenium
chemistry
has
become
a
significant
field
due
to
its
role
in
synthesizing
numerous
biologically
active
and
therapeutic
compounds.
In
early
phase,
researchers
focused
on
designing
organoselenium
compounds
with
antioxidant
properties
were
quite
successful.
last
two
decades,
synthetic
chemists
shifted
their
focus
toward
synthesis
of
biological
properties,
moving
beyond
traditional
properties.
The
review
includes
study
organo-selenium
as
anticancer,
antimicrobial,
antiviral,
antidiabetic,
antithyroid,
anti-inflammatory
therapies,
contributing
disease
treatment.
This
covers
the
medicinal
applications
over
past
10
years,
thus
making
it
valuable
resource
for
chemistry.
Chemistry - An Asian Journal,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 10, 2024
We
present
our
results
on
the
synthesis
and
preliminary
in
silico
vitro
studies
of
toxicology
antioxidant
properties
selenylated
analogs
Tacrine.
Initially,
we
synthesized
2-aminobenzonitriles
containing
an
organic
selenium
moiety,
resulting
sixteen
compounds
with
various
substituents
linked
to
portion
derived
from
diorganyl
diselenide.
These
were
then
used
as
substrates
reactions
cyclic
ketones,
presence
1.4
equivalents
trifluoroboroetherate
a
Lewis
acid,
synthesize
Tacrine
yields
ranging
20
%
87
%.
In
explored
computational
parameters
related
activity
hepatotoxicity.
elucidated
effects
its
hybrid
(TSe)
neutralizing
ABTS
radicals,
scavenging
DPPH
reducing
iron
ions.
Additionally,
acute
oral
toxicity
one
compound
was
evaluated.
Organic & Biomolecular Chemistry,
Journal Year:
2024,
Volume and Issue:
22(36), P. 7327 - 7331
Published: Jan. 1, 2024
A
simple
and
efficient
method
to
access
4-selenyl-isocoumarin
derivatives
through
visible-light-promoted
selenylation/cyclization
of
o
-(1-alkynyl)
benzoates
has
been
developed.
Chemistry - An Asian Journal,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 16, 2024
This
study
aims
to
describe
the
synthesis
of
a
new
class
selanylfullerene
derivatives
in
convergent
strategy
route,
affording
desired
products
few
steps
and
good
yields.
C
Journal of Medicinal Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 19, 2024
To
discover
new
osteoclast-targeting
antiosteoporosis
agents,
we
identified
forty-six
diselenyl
maleimides,
which
were
efficiently
prepared
using
a
novel,
simple,
and
metal-free
method
at
room
temperature
in
short
reaction
time.
Among
them,
Beilstein Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
20, P. 2434 - 2441
Published: Sept. 26, 2024
Trifluoromethoxylated
molecules
and
selenylated
compounds
find
a
wide
range
of
interesting
applications,
but
separately.
In
order
to
combine
the
potential
these
two
motifs
propose
new
class
compounds,
we
have
developed
an
electrophilic
phenylseleno
trifluoromethoxylation
alkenes,
which
leads
β-selenylated
trifluoromethoxylated
or,
upon
subsequent
reduction,
ones.
ChemBioChem,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 9, 2024
The
continuous
development
of
click
reactions
with
new
connecting
linkage
is
crucial
for
advancing
the
frontiers
chemistry.
Selenium-nitrogen
exchange
(SeNEx)
chemistry,
a
versatile
chemistry
in
represents
an
all-encompassing
term
nucleophilic
substitution
events
that
replace
nitrogen
at
electrophilic
selenium(II)
center,
enabling
flexible
and
efficient
assembly
linkages
around
Se(II)
core.
Several
SeNEx
chemistries
have
been
developed
inspired
by
biochemical
reaction
between
Ebselen
cysteine
residue,
demonstrated
significant
potential
on-plate
nanomole-scale
parallel
synthesis,
selenium-containing
DNA-encoded
library
(SeDEL)
as
well
peptide
protein
bioconjugation.
This
concept
aims
to
present
origins,
advancements,
applications
selenium(II)-nitrogen
while
also
outlining
directions
future
research
this
field.
