Atomistic Insights into the Ionic Response and Mechanism of Antifouling Zwitterionic Polymer Brushes

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 9, 2024

Zwitterionic polymer brushes are not a practical choice since their ionic response mechanisms unclear, despite great potential for surface antifouling modification. Therefore, atomic force microscopy and molecular dynamics simulations investigated the of electrical properties, hydration protein adhesion three types zwitterionic brushes. The PMPC (poly(2-methacryloyloxyethyl phosphorylcholine)) PSBMA (poly(sulfobetaine methacrylate)) in salt solution exhibits significant accumulation cations, which results positive shift potential. In contrast, demonstrates no notable change Furthermore, divalent Ca

Language: Английский

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Transcytosis-Triggering Nanoparticles for Overcoming Stromal Barriers and Reversing Immunosuppression in Pancreatic Cancer Combinatorial Therapy

Nano Letters, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

In pancreatic ductal adenocarcinoma (PDAC), stromal cells and matrix proteins form a dense physical barrier that, while preventing the outward spread of tumor cells, also limits penetration drugs CD8+ T inward. Additionally, overactivated TGF-β/SMAD signaling pathway further promotes proliferation immune suppression. Therefore, crossing preserving integrity stroma, releasing intratumorally, remodeling activating system is promising drug delivery strategy. this work, type enamine N-oxides modified nanoparticle was prepared, with stearic acid-modified gemcitabine prodrug (GemC18) pSMAD2/3 inhibitor galunisertib encapsulated. The peripheral can trigger transcytosis then respond to hypoxia acidic microenvironments, turning surface charge nanoparticles positive enhancing penetration. released inhibits pathway, reshapes matrix, activates antitumor immunity, combines (Gem) kill cells.

Language: Английский

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Endoplasmic Reticulum-Targeted Polymer-Manganese Nanocomplexes for Tumor Immunotherapy

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

Manganese ions (Mn2+) are an immune activator that enhances the activation of both cGAS and STING proteins. The signaling subsequential responses predominantly associated with endoplasmic reticulum (ER). Therefore, ER targeting Mn2+ in subcellular compartments would promote pathways. Herein, we report design ER-targeted manganese-based nanocomplexes (NCs) by complexation a zwitterionic polymer, poly[2-(N-oxide-N,N-dimethylamino) ethyl methacrylate] (OPDMA). Mn/OPDMA (Mn/OPDMA NCs) keep long blood circulation for tumor accumulation trigger adsorption-mediated transcytosis extravasation deep penetration. Notably, tumor-associated macrophages, NCs can preferentially translocate to their ERs, significantly enhancing cGAS-STING pathway macrophage polarization IFN-β secretion. In mouse colon hepatocellular cancer models, intravenously administrated efficiently remodel microenvironment, greatly retard growths 2.4- 5-fold, prolong survivals compared free Mn2+-treated mice. This study provides delivery achieves robust and, thus, potent systemic inhibition without toxicity Mn2+.

Language: Английский

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Harnessing Oxidized Amines as Robust Sorbents for Carbon Capture

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

Carbon capture and sequestration (CCS) is imperative to mitigating global climate change, but current implementation falls far short of that needed reach net-zero emissions by 2050. Aqueous amine solutions, conceived over a century ago, are the leading technology for CO2 separations. However, amines suffer from chemical instability under scrubbing conditions, corrosiveness, toxicity, hindering their long-term at multiton scales. Herein, we demonstrate first time tertiary N-oxides, an oxidative degradation product amines, can remove dilute streams, including flue gas natural gas-fired power plant. Our extensive spectroscopic computational studies support nontoxic, noncorrosive, inexpensive 4-methylmorpholine N-oxide (MMNO) captures humid conditions via formation hydrogen-bond-stabilized bicarbonate (HCO3-) species, despite being significantly less basic than amine. Accelerated aging show MMNO exhibits superior thermal stability compared structurally similar highlighting potential eco-friendly N-oxides in industrial carbon applications.

Language: Английский

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Antituberculosis, antimicrobial, antioxidant, cytotoxicity and anti-inflammatory activity of Schiff base derived from 2,3-diaminophenazine moiety and its metal(II) complexes: structural elucidation, computational aspects, and biological evaluation

Reviews in Inorganic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: July 29, 2024

Abstract Enticed by the present scenario of infectious diseases, four new Co(II), Ni(II), Cu(II), and Cd(II) complexes Schiff base ligand were synthesized from 6,6′-((1E-1′E)(phenazine-2,3-dielbis(azanylidene)-bis-(methanylidene)-bis-(3-(diethylamino)phenol)) ( H 2 L ) to ascertain as effective drug for antituberculosis, anti-inflammatory, antioxidant, cytotoxic antimicrobial activities. The organic its metal(II) characterized numerous physical spectroscopic methods, which showed that have a general formula, [ ML ], (where M = Co(II) C1 ), Ni(II) C2 Cu(II) C3 C4 )), metal been proposed square planar geometry, are amorphous in nature, thermally stable. Data highlight obtained activity testing against tuberculosis, inflammation, oxidants all compounds significantly active these symptoms. Also, was evaluate effectiveness various bacterial fungal strains. Specifically, strains Bacillus subtilis , Staphylococcus aureus Escherichia coli Pseudomonas aeruginosa two Aspergillus flavus Candida albicans tested compared results some standard drugs. revealed compound more than comparison In addition, found be most antibiotics fungi, while other moderate antifungal activity. Moreover, support vitro results, certain computational studies molecular docking studies, DFT, MESP, AMEDT also conducted confirm an tuberculosis. These is tuberculosis has desirable effects such absorption, no degradation hepatotoxicity, etc.

Language: Английский

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The Case for Poly(ylides) as a Class of Charge-Neutral, Hydrophilic Polymers with Applications in Biomaterials Science

Biomaterials Science, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Many applications of biomaterials require hydrophilic polymers as building blocks, including hydrogels and nanomedicinal devices. Besides enabling sufficient swelling properties in aqueous environments, provide hydration layers, which are considered a major requirement when designing non-fouling surfaces materials. For the last few decades, polyethylene glycol has been seen gold standard for such applications. However, reports on its stability immunogenicity have urged chemists to identify alternatives with comparable or superior properties. In addition biopolymers, zwitterionic gained increasing attention by effectively offering an overall charge-neutral scaffold capable forming strong layers. Driven enhanced understanding structure-property relationship materials, poly(ylides) emerged new class polymers. By having negative charge adjacent positive charge, ylides offer not only minimal dipole moment but also maintain their nature. Despite some early synthesis during 1980s, polymeric were largely overlooked polymers, utility unique blocks design tools remained elusive. recent years, several groups reported

Language: Английский

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Design, Synthesis, Anticancer Activity Evaluation and Molecular Dynamics Study of Pyrazine Nitrogen Oxide-Based Shp2 Allosteric Inhibitors

Published: Jan. 1, 2025

Language: Английский

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One-pot synthesis of 4-methyl-2-alkyl quinazoline-N-oxides by cascade acetamidation–acylation of simple electron-rich arenes with primary nitroalkanes

Tetrahedron, Journal Year: 2025, Volume and Issue: unknown, P. 134589 - 134589

Published: March 1, 2025

Language: Английский

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An Oxygen Walk Approach for C3 Selective Hydroxylation of Pyridines

Synlett, Journal Year: 2025, Volume and Issue: unknown

Published: March 14, 2025

Abstract Selective C3 functionalization of unbiased pyridines represents a significant challenge in organic synthesis. While seminal work this area has enabled access to various C3-substituted via dearomatized intermediates, the direct introduction hydroxy group at position is still challenging. In context, we have developed valence isomerization reaction triggered by photoexcitation pyridine N-oxides deliver synthetically challenging C3-hydroxy products. 1 Introduction 2 Recent Advances Radical-Based Pyridine Functionalization N-Oxides 3 C3-Selective Hydroxylation Pyridines through Oxygen Walking 4 Conclusion

Language: Английский

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Water-Soluble Sulfur-Ylide-Functionalized Polyacrylamides for Antibacterial Surface Applications

Langmuir, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Surface fouling induced by biomolecules and microorganisms remains a persistent challenge in materials science, particularly healthcare applications, where biofilm formation on medical devices may lead to infections antimicrobial resistance. Antifouling strategies typically rely the of either hydration layers or cytotoxic for direct effects. Recent advances zwitterionic polymers derived from ylides offer promising yet unexplored toolbox construction antifouling coatings. While N-oxide-based have been extensively studied as building blocks materials, sulfur-ylide-based precise underlying mechanisms remain underexplored despite their broader chemical versatility. Here, we present fully water-soluble acrylamide-based poly(sulfur ylide) compare its properties those previously reported hydrophobic polystyrene-derived analogues. Notably, ylides) retain efficacy surfaces but lose cytotoxicity solution, unlike counterpart. Computational studies reveal that dipole moment sulfur is environmentally responsive, stabilizing environments. Genetic analysis confirms outer membrane destabilization both suggests hydrophobicity polystyrene backbone promotes stronger interactions. We suggest future work should focus elucidating additional interactions, including supramolecular behaviors amphiphilic ylides, refine structure–property relationships optimize properties.

Language: Английский

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