Progress in the structural modification and pharmacological activity of isosteviol

Acta Materia Medica, Journal Year: 2025, Volume and Issue: 4(1)

Published: Jan. 1, 2025

Isosteviol and its derivatives, diterpene compounds with a wide range of biological activities, play important antiviral, antibacterial, antioxidant, antitumor, analgesic, anti-inflammatory, antipyretic, antifungal, anticardiovascular disease roles. Because unique skeleton, isosteviol is frequently used as an active framework in drug synthesis, thus helping medicinal chemists design highly selective, potentially active, multifunctional analogs for the treatment various diseases. In recent years, rapid developments synthesis derivatives have proven effective field chemistry research. This article briefly reviews novel obtained through structural modification isosteviol, including their pharmacological to provide reference development new synthetic strategies construction guide preclinical studies drugs greater efficacy.

Language: Английский

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Unraveling Small Molecule-Mediated Sirtuin 3 Activation at a Distinct Binding Site for Cardioprotective Therapies

ACS Central Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 13, 2025

Language: Английский

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Fungicidal Activity of Novel 6-Isothiazol-5-ylpyrimidin-4-amine-Containing Compounds Targeting Complex I Reduced Nicotinamide Adenine Dinucleotide Oxidoreductase

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 25, 2024

To discover novel inhibitors of the complex I reduced nicotinamide adenine dinucleotide (NADH) oxidoreductase as fungicides, a series 6-isothiazol-5-ylpyrimidin-4-amine-containing compounds were designed using computer-aided pesticide design method and splicing substructures from diflumetorim isotianil. In vitro fungicidal bioassays indicated that

Language: Английский

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Bilobalide ameliorates ovariectomy-induced osteoporosis by influencing SIRT3/NF-κB axis in osteoclast and promoting M2 polarization in macrophages

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 281, P. 136504 - 136504

Published: Oct. 10, 2024

Language: Английский

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Isosteviol: A potential cardioprotective agent

Arhiv za farmaciju, Journal Year: 2024, Volume and Issue: 74(5), P. 689 - 697

Published: Jan. 1, 2024

Cardioprotection is a term describing the myocardial property to protect itself from injury, particularly in context of ischemia-reperfusion injury and other metabolic stresses. Recently, isosteviol, diterpene derived hydrolysis stevioside, natural sweetener found leaves Stevia rebaudiana plant, has emerged as potential cardioprotective compound. In addition many therapeutic benefits including antihyperglycemic, antihypertensive, anti-inflammatory effects, recent studies have suggested that this compound might properties well. It been demonstrated isosteviol possesses antioxidant activities, while also regulating ion channels mitochondrial activity. The effects are mediated through its interaction with multiple signaling pathways. Pre-clinical work regulates NF-cB, phosphatidylinositol 3-kinase/Akt (PI3K/Akt) pathways, adenosine monophosphate-activated protein kinase (AMPK), all which well-established All these findings highlight isosteviol's agent. However, needs be further tested randomized controlled trials, along examining possible value clinical practice, defining optimal dosing strategies, understanding long-term effects.

Language: Английский

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Bioactive Matters based on Natural Product for Cardiovascular Diseases

Smart Materials in Medicine, Journal Year: 2024, Volume and Issue: 5(4), P. 542 - 565

Published: Nov. 16, 2024

Language: Английский

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