Near-infrared Photoimmunotherapy: mechanisms, applications, and future perspectives in cancer research DOI Creative Commons
Donald O. Allen,

Madeline JoAnna Szoo,

Tessa D. van Bergen

et al.

Antibody Therapeutics, Journal Year: 2025, Volume and Issue: 8(1), P. 68 - 85

Published: Jan. 1, 2025

Abstract Photoimmunotherapy (PIT) involves the targeted delivery of a photosensitizer through antibody conjugation, which, upon binding to its cellular target and activation by external irradiation, induces localized toxicity. This approach addresses several limitations conventional cancer therapies, such as chemo- radiotherapies, which result in off-target effects that significantly reduce patient quality life. Furthermore, PIT improves on challenges encountered with photodynamic therapy (PDT), nonspecific localization photosensitizer, often results unintended toxicities. Although was first proposed early 1980s, clinical applications have been constrained engineering, conjugation chemistries, optical technologies. However, recent advances antibody–drug conjugate (ADC) research emergence sophisticated laser technologies greatly benefited broader applicability PIT. Notably, near-infrared photoimmunotherapy (NIR-PIT) treatment for head neck has approved Japan is currently phase III trials USA. A significant advantage over traditional ADCs management agnostic nature PDT, making it more adaptable different tumor types. Specifically, can act stem cells displaying resistance aggressive phenotypes—a capability beyond scope alone. review provides an overview mechanism action NIR-PIT, highlighting adaptability application therapeutics, concludes exploring potential advancing treatments.

Language: Английский

Review of Carbon Nanotube Research and Development: Materials and Emerging Applications DOI Creative Commons
Kevin J. Hughes, Kavita A. Iyer, Robert E. Bird

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(16), P. 18695 - 18713

Published: Aug. 1, 2024

In this study, we present our findings from analyzing data contained in approximately 265,000 journal and patent publications the field of carbon nanotube (CNT)-related research spanning last two decades (2003 to 2023). The purpose study is identify extract prominent trends establish connections, such as those between materials applications. Using a natural language processing (NLP)-based analysis, have identified over 80 emerging concepts across three major categories (applications, materials, properties) CNTs, which presented "Trend Landscape" map. While early efforts appeared focus on synthesis techniques (including now well-established dominant technique chemical vapor deposition (CVD)), recent years has been driven by an increase interest CNT composites, especially involving other nanoscale MXene metal–organic frameworks (MOFs). High growth applications include use CNTs energy storage conversion technologies fuel cells, next-generation batteries, nanogenerators, sensors including wearable human motion sensors. Investment suggests commercial development variety industry types, semiconductors, energy, smaller extent biomedical industry. intent report serve useful guide researchers aid further exploration based

Language: Английский

Citations

23

Near-infrared Photoimmunotherapy: mechanisms, applications, and future perspectives in cancer research DOI Creative Commons
Donald O. Allen,

Madeline JoAnna Szoo,

Tessa D. van Bergen

et al.

Antibody Therapeutics, Journal Year: 2025, Volume and Issue: 8(1), P. 68 - 85

Published: Jan. 1, 2025

Abstract Photoimmunotherapy (PIT) involves the targeted delivery of a photosensitizer through antibody conjugation, which, upon binding to its cellular target and activation by external irradiation, induces localized toxicity. This approach addresses several limitations conventional cancer therapies, such as chemo- radiotherapies, which result in off-target effects that significantly reduce patient quality life. Furthermore, PIT improves on challenges encountered with photodynamic therapy (PDT), nonspecific localization photosensitizer, often results unintended toxicities. Although was first proposed early 1980s, clinical applications have been constrained engineering, conjugation chemistries, optical technologies. However, recent advances antibody–drug conjugate (ADC) research emergence sophisticated laser technologies greatly benefited broader applicability PIT. Notably, near-infrared photoimmunotherapy (NIR-PIT) treatment for head neck has approved Japan is currently phase III trials USA. A significant advantage over traditional ADCs management agnostic nature PDT, making it more adaptable different tumor types. Specifically, can act stem cells displaying resistance aggressive phenotypes—a capability beyond scope alone. review provides an overview mechanism action NIR-PIT, highlighting adaptability application therapeutics, concludes exploring potential advancing treatments.

Language: Английский

Citations

1