Carbon monoxide and mitochondria: Cell energy and fate control

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2024, Volume and Issue: 1870(7), P. 167446 - 167446

Published: July 29, 2024

Language: Английский

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Low-dose carbon monoxide inhalation to increase total hemoglobin mass and endurance performance: scientific evidence and implications

Frontiers in Physiology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 15, 2024

Recently, chronic intermittent inhalation of low-dose carbon monoxide (CO) has been postulated as a practice to increase total hemoglobin mass with potential beneficial effects on endurance performance. In this perspective article, we discuss the performance enhancing capabilities well safety concerns, which include individual variability in CO response, and acute health effects. It is also important note that according World-Anti-Doping-Agency (WADA), could fall under “ M1. Manipulation Blood Components therefore be considered prohibited method if used non-diagnostic tool.

Language: Английский

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Self-assembled carbon monoxide nanoprodrug for chemiexcitation-triggered synergistic chemotherapy against breast cancer

Science China Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

Language: Английский

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Severity of Repetitive Mild Traumatic Brain Injury Depends on Microglial Heme Oxygenase‐1 and Carbon Monoxide

European Journal of Neuroscience, Journal Year: 2025, Volume and Issue: 61(2)

Published: Jan. 1, 2025

ABSTRACT Traumatic brain injury is one of the most common cerebral incidences worldwide. Repetitive mild traumatic injuries occurring, for example, in athletes or victims abuse, can cause chronic neurodegeneration due to neuroinflammation, which crosstalk between reactive astrocytes and activated microglia crucial modulating neuronal damage. The inducible enzyme heme oxygenase‐1 its product carbon monoxide are known be ascribed neuroprotective anti‐inflammatory properties. We caused repetitive wild‐type mice compared without microglial expression. Additionally, were treated daily with either air exogenously. In mice, we observed enhanced activation astrogliosis as well vasodilation after trauma. knockout at baseline pretrauma a lack an adequate inflammatory response injury. However, led NF‐κB IFNγ expression post‐trauma period. Carbon exerted neuroprotection, suggested by reduced wake‐up times beneficially altering inflammation post‐traumatic This study further underlines role oxygenase‐1/carbon system modulation damage associated neuroinflammatory

Language: Английский

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Carbon monoxide potentiates the effect of corticosteroids in suppressing inflammatory responses in cell culture

Bioorganic & Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 118092 - 118092

Published: Jan. 1, 2025

Language: Английский

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Harnessing Gasotransmitters to Combat Age-Related Oxidative Stress in Smooth Muscle and Endothelial Cells

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(3), P. 344 - 344

Published: Feb. 27, 2025

Age-related oxidative stress is a critical factor in vascular dysfunction, contributing to hypertension and atherosclerosis. Smooth muscle cells endothelial are particularly susceptible damage, which exacerbates aging through cellular senescence, chronic inflammation, arterial stiffness. Gasotransmitters—hydrogen sulfide (H2S), nitric oxide (NO), carbon monoxide (CO)—are emerging as promising therapeutic agents for counteracting these processes. This review synthesizes findings from recent studies focusing on the mechanisms by H2S, NO, CO influence smooth cell function. Therapeutic strategies involving exogenous gasotransmitter delivery systems combination therapies were analyzed. H2S enhances mitochondrial bioenergetics, scavenges ROS, activates antioxidant pathways. NO improves function, promotes vasodilation, inhibits platelet aggregation. exhibits cytoprotective anti-inflammatory effects modulating heme oxygenase activity ROS production. In preclinical studies, gasotransmitter-releasing molecules (e.g., NaHS, SNAP, CORMs) targeted show significant promise. Synergistic with lifestyle modifications further enhance their potential. conclusion, gasotransmitters hold promise combat age-related cells. Their multifaceted innovative approaches make them potential candidates treating dysfunction promoting healthy aging. Further research needed translate into clinical applications.

Language: Английский

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Visible Light‐Triggered Precision SO₂ Release from Polymeric Nanomedicine for Cancer Therapy

Small, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Abstract A number of polymeric sulfur dioxide (SO 2 )‐releasing nanomedicines have demonstrated promise in cancer treatment by enabling controlled SO release, triggered endogenous (redox) stimuli. However, the heterogeneous distribution these stimuli across different organs presents a significant challenge to clinical translation. To overcome this limitation, developing donors that respond exogenous triggers offers promising strategy for therapeutic advancement. Herein, an stimuli‐responsive is presented generating from series amphiphilic block copolymers ( BCPx ) under visible light irradiation (427 nm) biological environment, aiming evaluate their potential therapy. The coumarin‐based, water‐soluble polymers form well‐defined nanostructures BCPxNs aqueous media, releasing 70–85% theoretical within 4 h. Moreover, exhibit self‐reporting behavior upon release. In vitro cellular assays with BCP2Ns demonstrate enhanced antiproliferative effect cervical carcinoma HeLa cells nm), IC 50 value 0.3 mg mL −1 . Investigations using confocal microscopy and flow cytometry confirm ‐induced cell death. Overall, underscores light‐responsive spatiotemporal control

Language: Английский

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CO as a potential therapeutic agent: an initial investigation of dosing and concentration dynamics in solution

Medicinal Chemistry Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Language: Английский

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OBESITY AND MITOCHONDRIAL UNCOUPLING – AN OPPORTUNITY FOR THE CARBON MONOXIDE-BASED PHARMACOLOGY OF METABOLIC DISEASES

Pharmacological Research, Journal Year: 2025, Volume and Issue: unknown, P. 107741 - 107741

Published: April 1, 2025

Language: Английский

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A novel pyrimidine-based hydrophilic fluorescent probe for detection and imaging of endogenous carbon monoxide in living organisms

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 142342 - 142342

Published: April 1, 2025

Language: Английский

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